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全身应用维生素C对外伤性晶状体脱位患者预后的影响
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Abstract:
目的：研究全身应用维生素C (Vc)对外伤性晶状体脱位患者预后的影响。方法：回顾性分析2022年1月1日至2024年5月30日在我院诊断为“外伤性晶状体脱位”的患者，收集一般资料、最佳矫正视力(BCVA)及眼部客观检查等数据，按是否全身使用Vc (2 g)分为两组(非Vc组与Vc组)，采用独立样本t检验比较两组的差异；采用相关分析研究末次复诊时BCVA与临床指标之间的关系。结果：共纳入51例患者，非Vc组26例，Vc组25例，除了非Vc组瞳孔直径显著小于Vc组外，两组间在入院资料上无显著差异。在全身加用Vc后，角膜水肿减轻时间显著缩短[非Vc组vs Vc组：3.00 (2.00, 4.00)天vs 3.00 (2.00, 3.00)天，P = 0.016]，出院后降眼压药物使用数量显著减少[非Vc组vs Vc组：1.00 (0.00, 2.00)种vs 0.00 (0.00, 1.00)种，P = 0.011]，末次复诊时BCVA显著好转[非Vc组vs Vc组：0.28 ± 0.05 vs 0.53 ± 0.06，P = 0.002]。进一步的相关分析发现，末次复诊时BCVA与入院BCVA分级(标准化的β：？0.656，P < 0.001)呈负相关，与全身应用Vc (标准化的β：0.505，P < 0.001)呈正相关。结论：Vc全身应用可显著改善外伤性晶状体脱位患者的预后，有临床广泛推广应用价值。
Objective: To investigate the prognostic impact of systemic application of vitamin C (Vc) on patients with traumatic lens dislocation. Methods: A retrospective analysis was conducted on patients diagnosed with “traumatic lens dislocation” in our hospital from January 1, 2022 to May 30, 2024. General information, best corrected visual acuity (BCVA), and objective eye examination data were collected. Patients were divided into two groups (non-Vc group and Vc group) based on whether Vc (2 g) was used systemically. Independent sample t-tests were used to compare the differences between the two groups. Then, correlation analysis was used to study the relationship between BCVA and clinical indicators at the last follow-up visit. Results: A total of 51 patients were included, with 26 in the non-Vc group and 25 in the Vc group. Except for the non-Vc group, which had a significantly smaller pupil diameter than the Vc group, there was no significant difference in admission data between the two groups. After systemic administration of Vc, the time for corneal edema reduction was significantly shortened [non-Vc group vs Vc group: 3.00 (2.00, 4.00) days vs 3.00 (2.00, 3.00) days, P = 0.016], and the number of intraocular pressure lowering medicines used after discharge was significantly reduced [non-Vc group vs Vc group: 1.00 (0.00, 2.00) types vs 0.00 (0.00, 1.00) types, P = 0.011]. At the last follow-up visit, BCVA improved significantly (non-Vc group vs Vc group: 0.28 ± 0.05 vs 0.53 ± 0.06, P = 0.002). Further correlation analysis revealed a negative correlation between BCVA and admission BCVA grading (standardized
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