SVX, a biotechnologically engineered biopolymer inspired by spider silk, presents a novel approach to the gradual release of active ingredients in cosmetic formulations. Produced through a single-step fermentation process, SVX’s unique 1003-amino acid sequence forms a porous matrix that enables controlled interactions with small and large molecular actives. This structure facilitates the encapsulation and sustained release of actives, addressing common challenges like irritation and rapid depletion. In vitro studies validated SVX’s capacity to gradually release glycolic acid, even after repeated wash cycles, contrasting with the rapid release seen in non-complexed GA formulations. In vivo tests utilized Fourier-transform infrared spectroscopy (FTIR) to track GA penetration and retention in the skin and tape-strip testing to analyze stratum corneum concentrations over time. These methods demonstrated sustained GA presence in the stratum corneum, preventing peak concentrations that often trigger irritation. Skin erythema assessments confirmed that SVX:GA formulations significantly reduce irritation compared to unencapsulated GA. Further investigations extended this controlled release mechanism to medium-molecular-weight hyaluronic acid, a key hydrating agent. In vitro hydration assays revealed prolonged moisture retention with the SVX:HA complex, while skin moisture content studies confirmed that SVX-treated skin retained moisture significantly longer than skin treated with free HA. These findings underscore SVX’s potential to enhance both the efficacy and tolerability of cosmetic actives, offering a versatile platform for next-generation skincare solutions.
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