Inflammatory myofibroblastic tumor has been referred to by many different names in the past, such as plasma cell granuloma, inflammatory pseudotumor, fibrous histiocytoma, fibroxanthoma, xanthogranuloma. It was first described in the 1930s. It originates from soft tissue. It has low malignancy potential. It is rarely seen. While it is often localized in the lungs, it can rarely be localized in the thyroid gland. Its etiology and pathogenesis are unknown. Diagnosis is based on postoperative immunohistochemical evaluation. Although surgical resection is the main treatment method, there is no standard approach. Recurrence is not expected in general. However, cases of recurrence after a long period of time have also been reported. In this study, a 46-year-old female patient was presented with thyroid inflammatory myofibroblastic tumor that developed after COVID-19. Another notable point in the case is that her mother had myeloma with mutations (changes in chromosomes 11 and 14).
References
[1]
Zhao, J., Han, D., Gao, M., Liu, M., Feng, C., Chen, G., et al. (2020) Inflammatory Myofibroblastic Tumor of the Neck with Thyroid Invasion: A Case Report and Literature Review. Gland Surgery, 9, 1042-1047. https://doi.org/10.21037/gs-20-355
[2]
Duan, J. and Wang, Y. (2017) A Case Report of Recurrent Thyroid Inflammatory Myofibroblastic Tumor and Its Metastasis in Soft Tissue. Medicine, 96, e8485. https://doi.org/10.1097/md.0000000000008485
[3]
Li, C., Wu, X., Wang, J., Wang, K., Zhang, S., Huang, J., et al. (2020) ALK-1-Positive Inflammatory Myofibroblastic Tumor of the Thyroid Complicated by Hashimoto’s Thyroiditis: Report of a Rare Case and a Literature Review. Diagnostic Pathology, 15, Article No. 58. https://doi.org/10.1186/s13000-020-00966-4
[4]
Matsubara, O., Tan-Liu, N.S., Kenney, R.M. and Mark, E.J. (1988) Inflammatory Pseudotumors of the Lung: Progression from Organizing Pneumonia to Fibrous Histiocytoma or to Plasma Cell Granuloma in 32 Cases. Human Pathology, 19, 807-814. https://doi.org/10.1016/s0046-8177(88)80264-8
[5]
Weinberger, S.E. (2023) Uptodate, Uptodate, Inflammatory Myofibroblastic Tumor (Plasma Cell Granuloma) of the Lung.
[6]
Demirhan, O., Ozkara, S., Yaman, M. and Kaynak, K. (2013) A Rare Benign Tumor of the Lung: Inflammatory Myofibroblastic Tumor—Case Report. Respiratory Medicine Case Reports, 8, 32-35. https://doi.org/10.1016/j.rmcr.2013.01.001
[7]
Deniz, K., Patirogˇlu, T.E. and Okten, T. (2008) Plasma Cell Granuloma of the Thyroid. Case Report. Journal of Pathology, Microbiology and Immunology, 116, 167-172. https://doi.org/10.1111/j.1600-0463.2008.00827.x
[8]
Mandelbaum, I., Brashear, R.E. and Hull, M.T. (1981) Surgical Treatment and Course of Pulmonary Pseudotumor (Plasma Cell Granuloma). The Journal of Thoracic and Cardiovascular Surgery, 82, 77-82. https://doi.org/10.1016/s0022-5223(19)39390-0
[9]
Kim, J.H., Cho, J.H., Park, M.S., Chung, J.H., Lee, J.G., Kim, Y.S., et al. (2002) Pulmonary Inflammatory Pseudotumor—A Report of 28 Cases. The Korean Journal of Internal Medicine, 17, 252-258. https://doi.org/10.3904/kjim.2002.17.4.252
[10]
Gal, A.A., Koss, M.N., McCarthy, W.F. and Hochholzer, L. (1994) Prognostic Factors in Pulmonary Fibrohistiocytic Lesions. Cancer, 73, 1817-1824. https://doi.org/10.1002/1097-0142(19940401)73:7<1817::aid-cncr2820730708>3.0.co;2-k
[11]
Fabre, D., Fadel, E., Singhal, S., de Montpreville, V., Mussot, S., Mercier, O., et al. (2009) Complete Resection of Pulmonary Inflammatory Pseudotumors Has Excellent Long-Term Prognosis. The Journal of Thoracic and Cardiovascular Surgery, 137, 435-440. https://doi.org/10.1016/j.jtcvs.2008.07.009
[12]
Chen, C.-H., Huang, W., et al. (2008) Surgical Outcome of Inflammatory Pseudotumor in the Lung. The Thoracic and Cardiovascular Surgeon, 56, 214-216. https://doi.org/10.1055/s-2007-989340
[13]
Weinberg, P.B., Bromberg, P.A. and Askin, F.B. (1987) “Recurrence” of a Plasma Cell Granuloma 11 Years after Initial Resection. Southern Medical Journal, 80, 519-521. https://doi.org/10.1097/00007611-198704000-00028
[14]
Cerfolio, R.J., Allen, M.S., Nascimento, A.G., Deschamps, C., Trastek, V.F., Miller, D.L., et al. (1999) Inflammatory Pseudotumors of the Lung. The Annals of Thoracic Surgery, 67, 933-936. https://doi.org/10.1016/s0003-4975(99)00155-1
