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In Vitro Evaluation of the Physicochemical Compatibility of Four Perfusion Mixtures: Case of an Ampoule of Paluject in Glucose Serum with/or without Vogalene

DOI: 10.4236/jmp.2024.1513098, PP. 2398-2406

Keywords: Physicochemical Compatibility and Stability, Perfusion, Paluject, Glucose Serum, Vogalene

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Abstract:

In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.

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