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阿托品在近视防控中不同作用机制的研究进展
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Abstract:
近年来近视发病率在全世界范围内不断攀升，尽管在政府及医院监管下，部分地区近视发病率较之前稍有下降，但因人群基数大，高度近视、病理性近视占比不断升高，现仍给社会、家庭及个人带来巨大负担。在近视防控过程中，常见的方法包括行为干预、光学及药物干预；其中阿托品已广泛应用在近视防控过程中，并取得了疗效。然而，尽管科学家们做了大量研究，阿托品的具体作用机制尚未完全明确，甚至不同研究得出的结论却都截然不同。本综述收集了不同的临床及动物实验，希望从不同的组织结构及分子生物的变化过程中进一步探索阿托品在近视防控过程中的作用机制，并为后续研究提供一些新思路。
In recent years, the incidence of myopia has been rising around the world. Although in some areas under the supervision of the government and hospitals, the incidence rate of myopia has dropped slightly than before, due to the large population base, the increasing proportion of high myopia and pathological myopia brings a huge burden to families and individuals. In the process of myopia prevention and control, common methods include behavioral intervention, optical, and drug intervention; among them, atropine has been widely used in the prevention and control of myopia and has achieved good results. However, despite extensive research by scientists, the specific mechanism of action of the product is not yet completely clear, and different studies have even reached completely different conclusions. This review collects different clinical and animal experiments that aim to summarize the role of atropine in the prevention and control of myopia from the changes in different tissue cells and molecular organisms and provide some new ideas for subsequent research.
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