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肠道菌群与矮小症相关性研究进展
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Abstract:
矮小症是指身高在同一种族、年龄和性别中比平均值低两个标准差。严重的身材矮小将会影响青少年儿童的心理健康和生活质量，密切关注儿童身高变化，及时明确病因并进行有效干预，对儿童青少年的健康成长具有重要意义。肠道菌群在调节免疫、维持肠上皮稳态、调节营养代谢以及激素水平中发挥着重要作用。菌群组成和功能异常将直接影响宿主健康，严重者可出现生长发育迟滞。近年来，部分临床研究探讨了肠道菌群在矮小症儿童中的调节作用，引起了人们广泛关注。本文结合课题组研究结果，对肠道菌群与矮小症的相关研究进行系统综述。
Short stature refers to individuals who are more than two standard deviations below the average height for the same race, age, and sex. Severe short stature will affect the mental health and quality of life of children and adolescents. It is important to pay close attention to the changes in children’s height, identify the causes of the disease in time and make effective interventions for the healthy growth of children and adolescents. Gut microbiota plays an important role in regulating immunity, maintaining intestinal epithelial homeostasis, regulating nutritional metabolism and hormone levels. Abnormalities in the composition and function of gut microbiota will directly affect the health of the host, and growth retardation may occur in severe cases. In recent years, some clinical studies have explored the regulatory role of gut microbiota in children with short stature, which has attracted widespread attention. In this paper, we combine the research results of our group to provide a systematic review of the studies related to gut microbiota and short stature.
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