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基于“脾主运化”理论探讨内质网应激与肥胖的关系
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Abstract:
随着我国经济增长，生活质量的提高，饮食结构的改变，肥胖已成为威胁我国国民健康的重大疾病。内质网应激在维持人体细胞内环境稳态，合成蛋白质，调节糖脂代谢等方面起着重要作用。肥胖时，细胞内的蛋白质过度累积，导致内质网过度应激，激活炎症通路，促进肥胖的发展。祖国传统医学在治疗肥胖时常通过燥湿健脾，调理中焦，调和脾胃等方法使脾运得复。现代药理学研究发现许多用于调理脾胃的中药能够缓解内质网应激，那么基于恢复“脾主运化”的功能，改善内质网过度应激以减轻肥胖带来的危害可以成为肥胖治疗的一个新切入点。
With China’s economic growth, the improvement of quality of life and the change of diet structure, obesity has become a major disease threatening the health of our people. Endoplasmic reticulum stress (ERS) plays an important role in maintaining the homeostasis of human cells, synthesizing proteins, and regulating glucose and lipid metabolism. In obesity, excessive accumulation of proteins in cells leads to excessive endoplasmic reticulum stress, activates inflammatory pathways, and promotes the development of obesity. In the treatment of obesity, traditional Chinese medicine often restores the spleen by drying dampness and invigorating the spleen, regulating the middle energizer, and harmonizing the spleen and stomach. Modern pharmacological studies have found that many traditional Chinese medicines used to regulate the spleen and stomach can alleviate endoplasmic reticulum stress. Therefore, based on the restoration of the function of “spleen governing transportation and transformation”, improving endoplasmic reticulum stress to reduce the harm caused by obesity can be a new entry point for obesity treatment.
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