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克罗恩病术后并发症发生的影响因素分析
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Abstract:
目的：分析影响克罗恩病患者在手术后30天内出现并发症的相关影响因素。方法：对88例接受手术治疗的克罗恩病患者进行回顾性资料分析，运用Logistic回归法探讨该患者群体在术后30天内发生并发症的相关因素。结果：共有15例患者出现术后并发症，其中3例肠梗阻，4例吻合口瘘，1例切口感染，5例腹腔感染，1例腹腔脓肿，1例泌尿系感染。根据Logistic多因素回归分析得出术前营养状态(P = 0.012, OR = 1.89, 95%CI: 1.682~2.190)、C-反应蛋白指数(P = 0.004, OR = 2.15, 95%CI: 1.301~2.652)以及术前CDAI评分的高低(P = 0.042, OR = 1.1051, 95%CI: 1.686~13.628)是影响克罗恩病患者术后发生并发症的危险因素，术前肠内营养可显著减少术后并发症的发生。结论：术前营养不良、CRP指标高、术前CDAI评分偏高是CD患者术后并发症发生的重要影响因素，因此这些因素可作为克罗恩病术后并发症发生风险的预测指标，而术前进行肠内营养支持有助于降低术后并发症的发生几率。
Objective: Analyze the relevant influencing factors that affect the occurrence of complications in Crohn’s disease patients within 30 days after surgery. Methods: A retrospective data analysis was conducted on 88 patients with Crohn’s disease who underwent surgical treatment, and Logistic regression was used to explore the related factors of complications in this patient population within 30 days after surgery. Results: A total of 15 patients experienced postoperative complications, including 3 cases of intestinal obstruction, 4 cases of anastomotic leakage, 1 case of incision infection, 5 cases of abdominal infection, 1 case of abdominal abscess, and 1 case of urinary tract infection. According to Logistic multiple regression score, the preoperative nutritional status (P = 0.012, OR = 1.89, 95%CI: 1.682~2.190), C-reactive protein index (P = 0.004, OR = 2.15, 95%CI: 1.301~2.652), and preoperative CDAI score (P = 0.042, OR = 1.1051, 95%CI: 1.686~13.628) were identified as factors affecting postoperative complications in patients with Crohn’s disease. Preoperative enteral nutrition can significantly reduce the incidence of postoperative complications. Conclusion: Preoperative malnutrition, high CRP levels, and high preoperative CDAI scores are important influencing factors for the occurrence of postoperative complications in CD patients. Therefore, these factors can serve as predictive indicators for the risk of postoperative complications in Crohn’s disease. Preoperative enteral nutrition support can help reduce the incidence of postoperative complications.
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