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Bioprocess 2024
肠道微生物与川崎病冠状动脉损伤关系研究进展
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Abstract:
川崎病是一种急性炎症性疾病，主要发生在5岁以下的婴幼儿中，其最严重的并发症是冠状动脉损伤。川崎病的发病机制尚未完全明确，但越来越多的证据表明肠道微生物在川崎病发生发展中发挥着重要作用。例如，肠道微生物群的失衡可能通过干扰免疫系统来促进川崎病的发展，而补充某些可以产生短链脂肪酸的肠道微生物能缓解川崎病引起的损伤，尤其是冠状动脉损伤。本研究通过查阅国内外文献，综述了肠道微生物在川崎病发生发展中的作用，为今后探索川崎病的新的防治方案提供依据。
Kawasaki disease is an acute inflammatory disease that mainly occurs in infants and young children under the age of 5, and its most serious complication is coronary artery injury. The pathogenesis of Kawasaki disease is not fully understood, but increasing evidence suggests that gut microbiota plays an important role in the occurrence and development of Kawasaki disease. For example, the imbalance of gut microbiota may promote the development of Kawasaki disease by interfering with the immune system, while supplementing certain gut microbiota that can produce short chain fatty acids can alleviate the damage caused by Kawasaki disease, especially coronary artery injury. This study reviewed the role of gut microbiota in the occurrence and development of Kawasaki disease by reviewing domestic and foreign literature, providing a basis for exploring new prevention and treatment strategies for Kawasaki disease in the future.
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