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基因组学在糖尿病肾病生物标志物应用中的研究进展
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Abstract:
糖尿病肾病(diabetic kidney disease, DKD)是糖尿病最普遍的合并症，同时也是终末期肾病的主要原因，已成为全球公共卫生问题。DKD的发病机制复杂，现有临床诊断指标存在不足，因而挖掘DKD新型生物标志物具有重要意义。本文基于基因组学技术的综合分析，从糖尿病肾病诊断预测和治疗靶点两个方面出发，对基因组学在糖尿病肾病生物标志物研究中的应用进行综述。
Diabetic kidney disease (DKD) is the most common comorbidity of diabetes mellitus and the main cause of end-stage renal disease (ESRD), which has become a global public health problem. The pathogenesis of DKD is complex, and the existing clinical diagnostic indexes are insufficient, so it is of great significance to explore the novel biomarkers of DKD. Based on the comprehensive analysis of genomics technology, this paper reviews the application of genomics in the study of biomarkers for diabetic kidney disease from the aspects of diagnostic prediction and therapeutic targets of diabetic kidney disease.
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