Mental Health and Psychosocial Support (MHPSS) needs among First Nation peoples in South America, Central America, Mexico, and the Spanish-speaking Caribbean are critical, yet often overlooked aspects of public health. This paper explores the multifaceted MHPSS needs of these communities, emphasizing how historical and contemporary factors significantly influence their mental and psychosocial health outcomes. Colonization, cultural dislocation, systemic discrimination, and socioeconomic challenges have created a complex landscape for mental and psychosocial health that necessitates a culturally sensitive and community-driven approach to MHPSS. The diverse cultural contexts of First Nation communities across these regions are examined, revealing unique traditions, languages, and belief systems that shape their understanding of mental and psychosocial health and well-being. These cultural elements play a crucial role in community resilience and coping strategies. However, the persistent impacts of colonization, including loss of land, language, and identity, continue to contribute to a high prevalence of mental and psychosocial health disorders, such as depression and anxiety. Additionally, the stigma surrounding mental and psychosocial health issues often prevents individuals from seeking help, exacerbating their struggles. The paper further highlights the importance of integrating traditional healing practices, appropriate native language use, and community-based approaches into MHPSS initiatives. By valuing local knowledge and involving community leaders and healers, interventions can be more effective and acceptable to Indigenous populations. Case studies from various communities are leveraged to illustrate successful MHPSS programs that respect cultural values while addressing contemporary mental health needs. The role of policy frameworks in supporting the MHPSS needs of First Nation peoples is discussed. Advocacy for appropriate funding, resources, and legislation is essential to ensure that mental and psychosocial health services are accessible and culturally and linguistically appropriate. The intersectionality of gender, age, and socioeconomic status within these communities also demands careful consideration, as different groups may experience unique pressures and challenges. In summary, addressing the MHPSS needs of First Nation peoples in South America, Central America, Mexico, and the Spanish-speaking Caribbean requires a holistic understanding of their cultural, historical, and social contexts. By fostering collaboration between
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