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高尿酸血症致冠心病作用机制研究进展
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Abstract:
高尿酸血症(Hyperuricemia, HUA)是由于人体长期嘌呤代谢活跃，嘌呤摄入过多，或尿酸排泄障碍引起的代谢性疾病。研究表明，HUA通过多种信号通路及作用机制，促进了以冠心病为代表的心血管疾病病程的发展。但由于共病的多样性和致病因素的复杂性，降尿酸治疗是否有益于降低心血管事件的发生率仍存争议。文章综述近年来有关高尿酸血症致冠心病作用机制，以期为疾病的临床防治提供参考。
Hyperuricemia (HUA) is a metabolic disease caused by long-term active purine metabolism, excessive purine intake, or impaired excretion of uric acid. Studies have shown that HUA promotes the development of cardiovascular disease course represented by coronary heart disease through multiple signaling pathways and mechanisms of action. However, due to the diversity of comorbidities and the complexity of pathogenic factors, whether uric acid-lowering therapy is beneficial in reducing the incidence of cardiovascular events remains controversial. This article summarizes the mechanism of coronary heart disease caused by hyperuricemia in recent years, in order to provide reference for the clinical prevention and treatment of diseases.
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