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帕金森病伴有神经精神症状对认知功能影响的研究进展
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Abstract:
轻度认知功能障碍(Mild cognitive impairment, MCI)是帕金森病(Parkinson’s disease, PD)最常见和重要的非运动症状之一，它可以在诊断PD之前或诊断时出现，并随着疾病的进展向PDD逐渐恶化，对患者自身生存质量、家庭经济情况造成显著影响。除了认知功能障碍，PD患者还会出现非认知的神经精神症状(Neuropsychiatric symptoms, NPS)，包括抑郁、焦虑、冲动控制障碍、冷漠和精神病。目前有学者发现抑郁、焦虑等症状是认知功能进展的重要危险因素，对MCI的病程及预后均有重要影响。因此本文将阐述帕金森病中神经精神症状与认知功能关系的国内外研究进展及可能存在的潜在机制。
Mild cognitive impairment (MCI) is one of the most common and significant non-motor symptoms of Parkinson’s disease (PD). It can manifest before or at the time of PD diagnosis and progressively deteriorates into Parkinson’s disease dementia (PDD) as the disease progresses, significantly impacting the quality of life of patients and their family’s economic situation. In addition to cognitive dysfunction, PD patients also exhibit non-cognitive neuropsychiatric symptoms (NPS), including depression, anxiety, impulse control disorders, apathy, and psychosis. Some studies have found that symptoms such as depression and anxiety are important risk factors for cognitive progression and significantly impact the course and prognosis of MCI. Therefore, this paper will outline the current research progress at home and abroad regarding the relationship between neuropsychiatric symptoms and cognitive function in Parkinson’s disease, as well as potential underlying mechanisms.
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