小儿原发性肾病综合征并发血栓栓塞的危险因素分析
Analysis of Risk Factors for Complicated Thromboembolism in Pediatric Primary Nephrotic Syndrome

目的：分析小儿原发性肾病综合征(PNS)并发血栓栓塞的危险因素。方法：回顾性分析本院于2022年2月~2023年2月期间收治的患儿，将50例发生栓塞患儿设为观察组，另选取同期入院治疗未发生栓塞的50例患者设为对照组，比较两组患儿之间各指标差异，并进行多因素logistic回归分析主要因素。结果：两组患儿在感染、利尿剂使用、白细胞计数、IgG、补体C3、总蛋白、白蛋白、尿素氮、血浆纤维蛋白原、D-二聚体、抗凝血酶、24 h尿蛋白定量各指标差异显著，具有统计学意义(p < 0.05)；logistic回归方程分析，D-二聚体和24 h蛋白尿定量为主要危险因素。结论：临床上，对于PNS患儿，应注意D-二聚体和24 h蛋白尿定量指标，以防发生血栓栓塞。
Objective: To analyze the risk factors of thromboembolism in pediatric primary nephrotic syndrome (PNS). Methods: In a retrospective analysis of children admitted from February 2022 to February 2023, 50 children with embolization were set as the observation group, and 50 patients without embolization in the same period were selected as the control group to compare the differences between the two groups, and multifactor logistic regression was conducted to analyze the main factors. Results: Infection, diuretic use, leukocyte count, IgG, complement C3, total protein, albumin, urea UN, plasma fibrinogen, D-dimer, antithrombin, and 24 h urinary protein between the two groups are significantly different, which has statistical significance (p < 0.05); logistic regression equation analysis, D-dimer and 24 h proteinuria were the main risk factors. Conclusion: Clinically, for children with PNS, attention should be paid to the D-dimer and 24 h proteinuria quantification to prevent thromboembolism.