Objective: A correlation study was conducted between AIDS awareness and condom use among 3128 freshmen in a border university to understand their knowledge of AIDS, their mastery of preventive measures, and their attitudes, and to explore the factors influencing their willingness to use condoms, with the aim of providing targeted and effective scientific recommendations for the prevention and treatment of AIDS and sexual health education in the region. Methods: A random whole-cluster sampling method was used, and a self-constructed questionnaire was administered to university freshmen via the Questionnaire Star platform to conduct a survey study, and SPSS 25.0 statistical software was used to analyze the relevant statistics. The c2 test and binary logistic regression were applied to analyze the influence factors. Results: The knowledge rate of freshmen about AIDS was 80.3%, and 5.7% of freshmen were not willing to use condoms when having sex. Multifactorial analysis showed that female students (OR = 3.96, 95% CI: 2.66 - 5.89), knowledge of AIDS (OR = 1.70, 95% CI: 1.19 - 2.42), unwillingness to have sex with others (OR = 2.12, 95% CI: 1.45 - 3.10), and having received AIDS education (OR = 0.34, 95% CI: 0.22 - 0.52) as facilitators influencing condom use. Conclusions: Freshmen in a border university have relatively good knowledge of AIDS and overall high willingness to use condoms, but still need to be improved. Schools should emphasize AIDS entrance education, focusing on health interventions for male students, establishing correct sexual concepts for new students, and improving AIDS knowledge to increase the rate of condom use among new students.
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