The Health-Related Quality of Life of Chronic Hepatitis B Virus Carriers Admitted to Yalgado OUEDRAOGO University Hospital, from January 31 to May 31, 2022, Burkina Faso
Introduction: According to the World Health Organization, chronic hepatitis B is the leading cause of mortality from liver disease and constitutes a public health problem. The aim of this study was to assess the quality of life of chronic hepatitis B virus carriers at the Yalgado OUEDRAOGO University hospital, and to identify the factors associated with this quality of life. Methods: We conducted a cross-sectional study at the Yalgado OUEDRAOGO University Hospital from January 31 to May 31, 2022, among chronic hepatitis B carriers aged at least 18 years who were followed for at least six months, treated or not. Results: The study included 135 patients, with an average age of 41.62 ± 10.69 years and a male predominance (64.44%). The average infection duration was 8.11 years ± 6, and the Chronic Liver Disease Questionnaire - Hepatitis B Virus (CLDQ-HBV) global quality of life score was 5.95 ± 0.90. Respondents’ overall quality of life was linked with gender, history of depression, and history of fatigue (ORa = 0.42 (p = 0.009), ORa = 1.57 (p < 0.001), and ORa = 1.19 (p < 0.001). In the “fatigue” factor, men had a 1.45-fold higher quality of life than women (p = 0.041). Patients without a history of depression had higher quality of life in “emotion” (ORa = 1.42; p < 0.001), “fatigue” (ORa = 1.67; p = 0.035), and “sleep” (ORa = 1.63; p < 0.0001). Finally, our study indicated that quality of life was improved without a history of fatigue. Conclusion: Our study enabled us to assess mean quality of life scores according to the CLDQ-HBV dimensions, and to identify factors associated with the quality of life of chronic HBV carrier patients. Public health measures such as early diagnosis and management, and free care related to this infection would improve the quality of life of these patients.
References
[1]
Organisation mondiale de la Santé (2017) Les nouvelles données sur l’hépatite soulignent le besoin urgent d’une riposte mondiale. https://www.who.int/fr/news/item/21-04-2017-new-hepatitis-data-highlight-need-for-urgent-global-response
[2]
Paccoud, O., Surgers, L. and Lacombe, K. (2019) Infection par le virus de l’hépatite B: Histoire naturelle, manifestations cliniques et principes thérapeutiques. La Revue de Médecine Interne, 40, 590-598. https://doi.org/10.1016/j.revmed.2019.03.333
[3]
Meda, N., Tuaillon, E., Kania, D., Tiendrebeogo, A., Pisoni, A., Zida, S., et al. (2018) Hepatitis B and C Virus Seroprevalence, Burkina Faso: A Cross-Sectional Study. Bulletin of the World Health Organization, 96, 750-759. https://doi.org/10.2471/blt.18.208603
[4]
Organisation mondiale de la santé (1986) Charte d’Ottawa—Promotion de la santé. https://nccdh.ca/fr/resources/entry/ottawa-charter-for-health-promotion
[5]
WHOQOL Group (1993) Study Protocol for the World Health Organization Project to Develop a Quality of Life Assessment Instrument (WHOQOL). Quality of Life Research, 2, 153-159. https://doi.org/10.1007/bf00435734
[6]
Liu, Y., Zhang, S., Zhao, Y., Du, J., Jin, G., Shao, S., et al. (2016) Development and Application of the Chinese (Mainland) Version of Chronic Liver Disease Questionnaire to Assess the Health-Related Quality of Life (HRQoL) in Patients with Chronic Hepatitis B. PLOS ONE, 11, e0162763. https://doi.org/10.1371/journal.pone.0162763
[7]
McPhail, S.M., Amarasena, S., Stuart, K.A., Hayward, K., Gupta, R., Brain, D., et al. (2020) Assessment of Health‐Related Quality of Life and Health Utilities in Australian Patients with Cirrhosis. JGH Open, 5, 133-142. https://doi.org/10.1002/jgh3.12462
[8]
Karacaer, Z., Cakir, B., Erdem, H., Ugurlu, K., Durmus, G., Ince, N.K., et al. (2016) Quality of Life and Related Factors among Chronic Hepatitis B-Infected Patients: A Multi-Center Study, Türkiye. Health and Quality of Life Outcomes, 14, Article No. 153. https://doi.org/10.1186/s12955-016-0557-9
[9]
Levy, A.R., Kowdley, K.V., Iloeje, U., Tafesse, E., Mukherjee, J., Gish, R., et al. (2008) The Impact of Chronic Hepatitis B on Quality of Life: A Multinational Study of Utilities from Infected and Uninfected Persons. Value in Health, 11, 527-538. https://doi.org/10.1111/j.1524-4733.2007.00297.x
[10]
Ong, S.C., Mak, B., Aung, M.O., Li, S. and Lim, S. (2008) Health‐Related Quality of Life in Chronic Hepatitis B Patients. Hepatology, 47, 1108-1117. https://doi.org/10.1002/hep.22138
[11]
Woo, G., Tomlinson, G., Yim, C., Lilly, L., Therapondos, G., Wong, D.K., et al. (2012) Health State Utilities and Quality of Life in Patients with Hepatitis B. Canadian Journal of Gastroenterology, 26, 445-451. https://doi.org/10.1155/2012/736452
[12]
Zhang, W., Wang, L. and Liu, Y. (2009) Evaluation on Quality of Life and Analysis on Its Correlation with TCM Syndromes in Patients of Chronic Hepatitis B. Chinese Journal of Integrative Medicine, 15, 30-33. https://doi.org/10.1007/s11655-009-0030-z
[13]
Martin, L. and Younossi, Z. (2005) Health-Related Quality of Life (HRQL) in Chronic Liver Disease. Digestive and Liver Disease, 37, 819-820. https://doi.org/10.1016/j.dld.2005.04.022
[14]
Wells, G.A., Russell, A.S., Haraoui, B., Bissonnette, R. and Ware, C.F. (2011) Validity of Quality of Life Measurement Tools—From Generic to Disease-Specific. The Journal of Rheumatology Supplement, 88, 2-6. https://doi.org/10.3899/jrheum.110906
[15]
Buti, M., Stepanova, M., Palom, A., Riveiro-Barciela, M., Nader, F., Roade, L., et al. (2021) Chronic Hepatitis D Associated with Worse Patient-Reported Outcomes than Chronic Hepatitis B. JHEP Reports, 3, Article 100280. https://doi.org/10.1016/j.jhepr.2021.100280
[16]
Li, G., Wang, G., Hsu, F., Xu, J., Pei, X., Zhao, B., et al. (2020) Effects of Depression, Anxiety, Stigma, and Disclosure on Health-Related Quality of Life among Chronic Hepatitis B Patients in Dalian, China. The American Journal of Tropical Medicine and Hygiene, 102, 988-994. https://doi.org/10.4269/ajtmh.19-0007
[17]
Sombié, R., Sangaré, L., Guingané, A., Tiendrébéogo, A., Kaboré, D. and Bougouma, A. (2015) Traitement de l’hépatite B chronique par les analogues de nucléos(t)ides. Journal Africain d’Hépato-Gastroentérologie, 9, 114-118. https://doi.org/10.1007/s12157-015-0601-4
[18]
Mahassadi, A.K., Team Machekam, O. and Attia, A.K. (2020) The Impact of Virologic Parameters and Liver Fibrosis on Health-Related Quality of Life in Black African Patients with Chronic Hepatitis B: Results from a High Endemic Area. Clinical and Experimental Gastroenterology, 13, 407-418. https://doi.org/10.2147/ceg.s255102
[19]
Weinstein, A.A., Kallman Price, J., Stepanova, M., Poms, L.W., Fang, Y., Moon, J., et al. (2011) Depression in Patients with Nonalcoholic Fatty Liver Disease and Chronic Viral Hepatitis B and C. Psychosomatics, 52, 127-132. https://doi.org/10.1016/j.psym.2010.12.019
[20]
Somda, K.S., Sermé, A.K., Coulibaly, A., Zoungrana, S.L., Compaoré, I., Kouamou, S., et al. (2016) Treatment of HBeAg-Negative Chronic Hepatitis B Patients with Nucleos(t)ide Analogues in Burkina Faso. Open Journal of Gastroenterology, 6, 387-396. https://doi.org/10.4236/ojgas.2016.612041
[21]
Saffari, M., Pakpour, A.H., Zaben, F.A. and Koenig, H.G. (2017) Is There an Association between Health Related Quality of Life, Socio-Demographic Status and Fatigue in Patients with Chronic Hepatitis B? Acta Gastro-Enterologica Belgica, 80, 229-236.
[22]
Younossi, Z.M., Stepanova, M., Younossi, I., Papatheodoridis, G., Janssen, H.L.A., Agarwal, K., et al. (2019) Patient‐Reported Outcomes in Patients Chronic Viral Hepatitis without Cirrhosis: The Impact of Hepatitis B and C Viral Replication. Liver International, 39, 1837-1844. https://doi.org/10.1111/liv.14171
[23]
Drazic, Y.N. and Caltabiano, M.L. (2012) Chronic Hepatitis B and C: Exploring Perceived Stigma, Disease Information, and Health‐Related Quality of Life. Nursing & Health Sciences, 15, 172-178. https://doi.org/10.1111/nhs.12009
[24]
Organisation mondiale de la Santé (2018) Genre et santé. https://www.who.int/fr/news-room/fact-sheets/detail/gender
[25]
Younossi, Z.M., Stepanova, M., Younossi, I. and Racila, A. (2020) Development and Validation of a Hepatitis B‐Specific Health‐Related Quality‐of‐Life Instrument: CLDQ‐HBV. Journal of Viral Hepatitis, 28, 484-492. https://doi.org/10.1111/jvh.13451
[26]
Lam, E.T., Lam, C.L., Lai, C., Yuen, M., Fong, D.Y. and So, T.M. (2009) Health-Related Quality of Life of Southern Chinese with Chronic Hepatitis B Infection. Health and Quality of Life Outcomes, 7, Article No. 52. https://doi.org/10.1186/1477-7525-7-52
[27]
Bondini, S., Kallman, J., Dan, A., Younoszai, Z., Ramsey, L., Nader, F., et al. (2007) Health‐Related Quality of Life in Patients with Chronic Hepatitis B. Liver International, 27, 1119-1125. https://doi.org/10.1111/j.1478-3231.2007.01558.x
[28]
Obradovic, M., Gluvic, Z., Petrovic, N., Obradovic, M., Tomasevic, R., Dugalic, P., et al. (2017) A Quality of Life Assessment and the Correlation between Generic and Disease-Specific Questionnaires Scores in Outpatients with Chronic Liver Disease-Pilot Study. Romanian Journal of Internal Medicine, 55, 129-137. https://doi.org/10.1515/rjim-2017-0014
[29]
Zhuang, G., Zhang, M., Liu, Y., Guo, Y., Wu, Q., Zhou, K., et al. (2014) Significant Impairment of Health-Related Quality of Life in Mainland Chinese Patients with Chronic Hepatitis B: A Cross-Sectional Survey with Pair-Matched Healthy Controls. Health and Quality of Life Outcomes, 12, Article No. 101. https://doi.org/10.1186/1477-7525-12-101
[30]
Mejdoub, Y., Koubaa, M., Trabelsi, J., Gargouri, M., Chhaidar, B., Agrebi, S., et al. (2016) HEP-18-L’impact de l’hépatite B chronique sur la qualité de vie selon l’échelle SF-36. Médecine et Maladies Infectieuses, 46, 56. https://doi.org/10.1016/s0399-077x(16)30395-x
[31]
Altindag, A., Cadirci, D. and Sirmatel, F. (2009) Depression and Health Related Quality of Life in Non-Cirrhotic Chronic Hepatitis B Patients and Hepatitis B Carriers. Neurosciences, 14, 56-59.
[32]
Keskin, G., Gümüs, A.B. and Orgun, F. (2013) Quality of Life, Depression, and Anxiety among Hepatitis B Patients. Gastroenterology Nursing, 36, 346-356. https://doi.org/10.1097/sga.0b013e3182a788cc
[33]
Chao, J., Song, L., Zhang, H., Zhu, L., Tian, L., Jin, H., et al. (2013) Effects of Comprehensive Intervention on Health-Related Quality of Life in Patients with Chronic Hepatitis B in China. BMC Health Services Research, 13, Article No. 386. https://doi.org/10.1186/1472-6963-13-386
[34]
Wang, H., Zhou, Y., Yan, R., Ru, G.Q., Yu, L.L. and Yao, J. (2019) Fatigue in Chronic Hepatitis B Patients Is Significant and Associates with Autonomic Dysfunction. Health and Quality of Life Outcomes, 17, Article No. 130. https://doi.org/10.1186/s12955-019-1200-3
[35]
Gupta, R., Avasthi, A., Chawla, Y.K. and Grover, S. (2020) Psychiatric Morbidity, Fatigue, Stigma and Quality of Life of Patients with Hepatitis B Infection. Journal of Clinical and Experimental Hepatology, 10, 429-441. https://doi.org/10.1016/j.jceh.2020.04.003
[36]
Zhu, L., Kong, J., Zheng, Y., Song, M., Cheng, X., Zhang, L., et al. (2019) Development and Initial Validation of the Chronic Hepatitis B Quality of Life Instrument (CHBQOL) among Chinese Patients. Quality of Life Research, 28, 3071-3081. https://doi.org/10.1007/s11136-019-02240-7
[37]
Jones, D.E., Al-Rifai, A., Frith, J., Patanwala, I. and Newton, J.L. (2010) The Independent Effects of Fatigue and UDCA Therapy on Mortality in Primary Biliary Cirrhosis: Results of a 9 Year Follow-up. Journal of Hepatology, 53, 911-917. https://doi.org/10.1016/j.jhep.2010.05.026
[38]
Bedossa, P. and Poynard, T. (1996) An Algorithm for the Grading of Activity in Chronic Hepatitis C. Hepatology, 24, 289-293. https://doi.org/10.1002/hep.510240201
[39]
Kallman, J., O’Neil, M.M., Larive, B., Boparai, N., Calabrese, L. and Younossi, Z.M. (2007) Fatigue and Health-Related Quality of Life (HRQL) in Chronic Hepatitis C Virus Infection. Digestive Diseases and Sciences, 52, 2531-2539. https://doi.org/10.1007/s10620-006-9708-x
[40]
Kim, J., Kim, M.W., Kim, J., Han, S. and Kim, S. (2014) Factors Influencing Health Related Quality of Life among Patients with Chronic Hepatitis B. Korean Journal of Adult Nursing, 26, 287-299. https://doi.org/10.7475/kjan.2014.26.3.287
