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TGF-β与胃癌形成及改变机制关系研究进展
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Abstract:
胃癌是我国目前较常见恶性肿瘤之一，最近科学家研究发现其发病原因与肿瘤免疫逃逸有关，其中目前研究较为深入的是肿瘤微环境介导的免疫逃逸。转化生长因子-β (TGF-β)属于调节细胞生长分化的转化因子家族细胞因子之一，它与许多恶性肿瘤生长转移有关，其中转化生长因子-β与胃癌的关系较为密切。本文主要对TGF-β以及胃癌形成改变机制研究进展作一简单的介绍。
Gastric cancer is one of the most common malignant tumors in our country. Recent scientific studies have found that its etiology is related to tumor immune evasion, with a particular focus on immune evasion mediated by the tumor microenvironment. Transforming growth factor beta (TGF-β) is one of the cytokines belonging to the family of transforming factors that regulate cell growth and differentiation. It is associated with the growth and metastasis of various malignant tumors, with a particularly close relationship to gastric cancer. This article provides a brief overview of the research progress on TGF-β and the mechanisms by which it influences the development of gastric cancer.
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