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针灸治疗阿尔兹海默症的临床研究进展
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Abstract:
阿尔茨海默症(AD)是一种以智力下降、丧失工作能力、不能正常工作和生活能力为特征的疾病,多见于老年患者。2015年,全球有大约4680万的AD患者,而到2050年,这个数字将达到1.3亿。2015年,我国阿尔茨海默病已高达900万,专家预测,2030年我国将出现1000多万人。AD的发病率在老年人中较高,并具有明显的年龄高发性,并随着年龄的增加而迅速增加。国外的研究显示,AD在65岁和95岁以上老年人的发病率分别为1%和50%。目前常用的西医药物只能缓解AD的一些症状,但存在一些毒副作用。中医药治疗AD疗效确切,作用靶点多,协同效应少,副作用少,值得深入研究。其中针灸作为常用的一种方法,近些年已经成为研究的热点。本文就针灸治疗阿尔兹海默症的机制和方法进行综述,为此病的防治提供参考。
Alzheimer’s disease (AD) is a disease characterized by intellectual decline, loss of work ability, inability to work and live normally, and is more common in elderly patients. In 2015, there were approximately 46.8 million AD patients worldwide, and by 2050, this number will reach 130 million. In 2015, the incidence of Alzheimer’s disease in China reached 9 million, and experts predict that there will be over 10 million people in China by 2030. The incidence rate of AD is relatively high in the elderly, and has obvious age high incidence, which increases rapidly with age. Foreign studies show that the incidence rate of AD in the elderly aged 65 and over 95 is 1% and 50% respectively. Currently, commonly used Western medicine drugs can only alleviate some symptoms of AD, but there are some toxic side effects. Traditional Chinese medicine has a definite therapeutic effect on AD, with multiple targets, few synergistic effects, and few side effects, which is worthy of further research. Among them, acupuncture and moxibustion, as a commonly used method, has become a research hotspot in recent years. This article reviews the mechanism and methods of acupuncture and moxibustion in the treatment of Alzheimer’s disease to provide reference for the prevention and treatment of this disease.
[1] | 肖世富, 薛海波, 李冠军, 等. 老年轻度认知功能损害的随访研究[J]. 中华医学杂志, 2006, 86(21): 1441-1446. |
[2] | 张振华, 冯晓东, 李瑞青, 等. 微小RNA在轻度认知功能障碍诊断中的研究进展[J]. 中国老年学杂志, 2021, 41(12): 2662-2666. |
[3] | 张赓, 吴金娟, 姜淼, 等. 中医药治疗阿尔兹海默病的研究进展[J]. 中国实验方剂学杂志, 2014, 20(6): 217-222. |
[4] | 刘佳琳, 王帅, 赖碧琴, 等. 兴奋作用的间歇性Theta节律爆发式刺激模式经颅磁刺激对大鼠全横断脊髓损伤早期脑内炎症及神经元凋亡的影响[J]. 中国康复医学杂志, 2023, 38(11): 1485-1492. |
[5] | 王石艳, 王彤. 有氧运动预防并治疗阿尔兹海默病所致轻度认知损害的研究进展[J]. 中华物理医学与康复杂志, 2015, 37(1): 75-78. |
[6] | 周友龙, 韩红艳. 针灸治疗阿尔兹海默病的临床研究进展[J]. 针灸临床杂志, 2006, 22(11): 50-53. |
[7] | 潘建涛, 于倩倩, 杨洋. 补肾益智方联合针灸对阿尔兹海默症患者氧化应激指标水平的干预作用[J]. 世界中西医结合杂志, 2017, 12(11): 1554-1557. |
[8] | 姜婧, 李志刚. 电针治疗阿尔兹海默病的基础研究进展[J]. 世界科学技术: 中医药现代化, 2015, 17(2): 405-410. |
[9] | 王斓, 陈浙丽, 徐亮, 等. 头针配合综合康复训练对早期阿尔兹海默症患者认知功能的影响[J]. 辽宁中医杂志, 2022, 49(3): 178-181. |
[10] | 夏昆鹏, 李全, 尹洪娜, 等. 头穴埋线对阿尔兹海默病患者认知功能及血管修复因子、可溶性凋亡因子的影响[J]. 针灸临床杂志, 2018, 34(12): 33-35. |
[11] | 崔耀辉, 李彭妮, 常陆春, 等. 针刺联合脐灸治疗阿尔兹海默病临床观察[J]. 光明中医, 2023, 38(10): 1916-1919. |
[12] | 苏全德, 何晓慧. 温和灸治疗阿尔茨海默病疗效观察[J]. 上海针灸杂志, 2018, 37(6): 623-625. |
[13] | 刘源香, 杨继国. 督脉灸疗法对阿尔茨海默病模型小鼠学习记忆能力及海马CA1、CA3区HE染色的影响[J]. 山东中医杂志, 2017, 36(12): 1059-1062. |