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不同部位消化道肿瘤的太赫兹光谱
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Abstract:
目前，临床诊断癌症的金标准是病理学的检测。但是该操作需要进行活检或内镜活检，这是一种侵入性检查，且一定程度上受制于医师的经验水平，因此不能作为肺癌的早期诊断和常规体格检查。近年来，太赫兹光谱技术已应用于多种癌种的肿瘤组织与正常组织之间的检测。因此，探索一种高分辨率的检测方法来区分癌组织和癌旁组织具有重要意义，可以实现癌症的早发现、早诊断、早治疗。在这项研究中，我们利用太赫兹时域光谱技术研究胃肠道肿瘤组织与正常组织之间的关系，以及胃肠道不同部位肿瘤组织之间的关系。通过测量折射率、吸收系数，我们发现肿瘤组织与正常组织的太赫兹光谱曲线存在显著差异。消化道不同部位肿瘤的太赫兹光谱曲线也表现出不同的趋势。因此，太赫兹时域光谱技术具有区分肿瘤和正常组织的潜力。
At present, the golden standard for clinical diagnosis of cancer is pathological examination. However, this procedure requires a biopsy or endoscopic biopsy, which is invasive examinations and limited by physician’s level of experience. Therefore, it can not be used as an early diagnosis and routine physical examination for lung cancer. In recent years, terahertz spectroscopy has been applied to detect tumor tissues and normal tissues of many kinds of cancers. Therefore, it is of great significance to explore a high-resolution detection method to distinguish cancer tissues from para-cancer tissue, which can realize early detection, early diagnosis and early treatment of cancer. In this study, we use terahertz time-domain spectroscopy to investigate the relationship between gastrointestinal tumor tissue and normal tissue, as well as the relationship between tumor tissue at different sites of the gastrointestinal tract. By measuring the refractive index and absorption constant, we find that the terahertz spectra of tumor tissues are significantly different from those of normal tissues. The terahertz spectroscopy of tumors in different parts of digestive tract also shows different trends. Therefore, terahertz time-domain spectroscopy has the potential to differentiate tumor from normal tissue.
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