|
|
外泌体与椎间盘退变关系的研究进展
|
Abstract:
椎间盘退变是一种复杂的与年龄相关的生物学改变，受到多种因素影响。随着人口老龄化和生活方式的改变，其发病率不断上升，给社会带来沉重负担。外泌体作为细胞间交流的重要媒介，在椎间盘退变过程中具有关键作用。本文详细综述了外泌体的基本特性，深入探讨了其在椎间盘退变中的作用机制，包括对髓核细胞功能、炎症反应、细胞外基质代谢和细胞间通讯的影响，并阐述了基于外泌体的治疗策略以及面临的挑战与展望，旨在为椎间盘退变的研究和治疗提供新的思路。
Intervertebral disc degeneration is a complex age-related biological change affected by multiple factors. With the aging of the population and the change of lifestyle, its incidence is increasing, which brings a heavy burden to society. As an important medium of intercellular communication, exosomes play a key role in the process of intervertebral disc degeneration. In this paper, the basic properties of exosomes are reviewed in detail, and the mechanism of action of exosomes in intervertebral disc degeneration is discussed in detail, including their effects on nucleus pulposus cell function, inflammatory response, extracellular matrix metabolism and intercellular communication. In addition, exosome-based therapeutic strategies, challenges and prospects are described, with the aim of providing new ideas for the research and treatment of intervertebral disc degeneration.
| [1] | 杨翔宇, 李晓红, 肖静, 等. 干扰素γ刺激hUC-MSCs分泌外泌体促进调节性T细胞生成[J]. 中国药理学通报, 2017, 33(1): 45-51. |
| [2] | 世界中医药学会联合会骨质疏松专业委员会, 阎小萍, 王拥军, 等. 腰椎间盘突出症中西医结合诊疗专家共识[J]. 世界中医药, 2023, 18(7): 945-952. |
| [3] | Hornung, A.L., Barajas, J.N., Rudisill, S.S., Aboushaala, K., Butler, A., Park, G., et al. (2023) Prediction of Lumbar Disc Herniation Resorption in Symptomatic Patients: A Prospective, Multi-Imaging and Clinical Phenotype Study. The Spine Journal, 23, 247-260. https://doi.org/10.1016/j.spinee.2022.10.003 |
| [4] | 张文捷, 张勇, 史明, 等. 淫羊藿苷调控髓核来源间充质干细胞凋亡修复椎间盘退变[J]. 中国组织工程研究, 2023, 27(24): 3803-3809. |
| [5] | 卢婉, 杨人强, 王伶. 外泌体的研究进展[J]. 生命的化学, 2013, 33(4): 438-442. |
| [6] | Miao, R., Jiang, C., Chang, W.Y., Zhang, H., An, J., Ho, F., et al. (2023) Gasdermin D Permeabilization of Mitochondrial Inner and Outer Membranes Accelerates and Enhances Pyroptosis. Immunity, 56, 2523-2541.e8. https://doi.org/10.1016/j.immuni.2023.10.004 |
| [7] | 赵继荣, 杨正汉, 陈文, 等. 中医药治疗腰椎间盘突出症术后腰腿痛研究进展[J]. 辽宁中医药大学学报, 2023, 25(10): 1-5. |
| [8] | 李姣, 黄委委, 陶林, 等. 名老中医治疗腰椎间盘突出症经验荟萃[J]. 颈腰痛杂志, 2022, 43(2): 283-284, 290. |
| [9] | 高夕林, 岳宝成, 潘仁慈, 等. 独活寄生汤加味联合中医手法治疗腰椎间盘突出症[J]. 吉林中医药, 2022, 42(6): 733-736. |
| [10] | 魏向东. 从《金匮要略∙水气病》浅谈气血水[J]. 中医临床研究, 2020, 12(33): 44, 127. |
| [11] | 王宜灿, 张虎林, 汪小敏, 等. 中药促进髓核细胞自噬延缓椎间盘退变的研究进展[J]. 颈腰痛杂志, 2023, 44(4): 680-682. |
| [12] | 李劲松. 腰椎间盘突出症患者的辨证施护及疗效观察——评《腰椎间盘突出症第3版》[J]. 世界中医药, 2023, 18(7): 1057. |
| [13] | Takeuchi, S., Hanakita, J., Takahashi, T., Inoue, T., Minami, M., Suda, I., et al. (2022) Predictive Factors for Poor Outcome Following Chemonucleolysis with Condoliase in Lumbar Disc Herniation. Medicina, 58, Article 1868. https://doi.org/10.3390/medicina58121868 |
| [14] | Jiang, H.W., Chen, C.D., Zhan, B.S., Wang, Y.L., Tang, P. and Jiang, X.S. (2022) Unilateral Biportal Endoscopic Discectomy versus Percutaneous Endoscopic Lumbar Discectomy in the Treatment of Lumbar Disc Herniation: A Retrospective Study. Journal of Orthopaedic Surgery and Research, 17, Article No. 30. https://doi.org/10.1186/s13018-022-02929-5 |
