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细胞因子在新生儿败血症早期诊断中的研究进展
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Abstract:
新生儿败血症早期临床表现缺乏特异性，且病情进展迅速，可造成多脏器功能损伤甚至死亡。新型的生物标记物如细胞因子，在既往的研究中已被证实与疾病的早期诊断相关。本文对细胞因子在新生儿败血症早期诊断中的研究进展进行综述。
The early clinical manifestations of neonatal sepsis are lack of specificity, and the disease progresses rapidly, which can cause multiple organ dysfunction and even death. Novel biomarkers such as cytokines have been shown to be associated with disease diagnosis and prognosis in previous studies. This article reviews the research progress of cytokines in the early diagnosis of neonatal septicemia.
| [1] | 江载芳, 申昆玲, 沈颖. 诸福棠实用儿科学[M]. 第8版. 北京: 人民卫生出版社, 2015: 491-495. |
| [2] | Shane, A.L., Sánchez, P.J. and Stoll, B.J. (2017) Neonatal Sepsis. The Lancet, 390, 1770-1780. https://doi.org/10.1016/s0140-6736(17)31002-4 |
| [3] | 陆文峰, 张洁, 方成志. 新生儿败血症情况及早期诊断指标分析[J]. 中国妇幼健康研究, 2017, 28(8): 908-910. |
| [4] | 中华医学会儿科学分会新生儿学组, 中国医师协会新生儿科医师分会感染专业委员会. 新生儿败血症诊断及治疗专家共识(2019年版) [J]. 中华儿科杂志, 2019, 57(4): 252-257. |
| [5] | Delanghe, J.R. and Speeckaert, M.M. (2015) Translational Research and Biomarkers in Neonatal Sepsis. Clinica Chimica Acta, 451, 46-64. https://doi.org/10.1016/j.cca.2015.01.031 |
| [6] | Chauhan, N., Tiwari, S. and Jain, U. (2017) Potential Biomarkers for Effective Screening of Neonatal Sepsis Infections: An Overview. Microbial Pathogenesis, 107, 234-242. https://doi.org/10.1016/j.micpath.2017.03.042 |
| [7] | Mihara, M., Hashizume, M., Yoshida, H., Suzuki, M. and Shiina, M. (2011) IL-6/IL-6 Receptor System and Its Role in Physiological and Pathological Conditions. Clinical Science, 122, 143-159. https://doi.org/10.1042/cs20110340 |
| [8] | Chiesa, C., Pacifico, L., Natale, F., Hofer, N., Osborn, J.F. and Resch, B. (2015) Fetal and Early Neonatal Interleukin-6 Response. Cytokine, 76, 1-12. https://doi.org/10.1016/j.cyto.2015.03.015 |
| [9] | Shahkar, L., Keshtkar, A., Mirfazeli, A., Ahani, A. and Roshandel, G. (2011) The Role of IL-6 for Predicting Neonatal Sepsis: A Systematic Review and Meta-Analysis. Iranian Journal of Pediatrics, 21, 411-417. |
| [10] | Kurul, Ş., Simons, S.H.P., Ramakers, C.R.B., De Rijke, Y.B., Kornelisse, R.F., Reiss, I.K.M., et al. (2021) Association of Inflammatory Biomarkers with Subsequent Clinical Course in Suspected Late Onset Sepsis in Preterm Neonates. Critical Care, 25, Article No. 12. https://doi.org/10.1186/s13054-020-03423-2 |
| [11] | Ye, Q., Du, L., Shao, W. and Shang, S. (2016) Utility of Cytokines to Predict Neonatal Sepsis. Pediatric Research, 81, 616-621. https://doi.org/10.1038/pr.2016.267 |
| [12] | Cortés, J.S., Losada, P.X., Fernández, L.X., Beltrán, E., DeLaura, I., Narváez, C.F., et al. (2020) Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis. American Journal of Perinatology, 38, e338-e346. https://doi.org/10.1055/s-0040-1710010 |
| [13] | Cobo, T., Kacerovsky, M., Andrys, C., Drahosova, M., Musilova, I., Hornychova, H., et al. (2013) Umbilical Cord Blood IL-6 as Predictor of Early-Onset Neonatal Sepsis in Women with Preterm Prelabour Rupture of Membranes. PLOS ONE, 8, e69341. https://doi.org/10.1371/journal.pone.0069341 |
| [14] | Eichberger, J. and Resch, B. (2022) Reliability of Interleukin-6 Alone and in Combination for Diagnosis of Early Onset Neonatal Sepsis: Systematic Review. Frontiers in Pediatrics, 10, Article 840778. https://doi.org/10.3389/fped.2022.840778 |
| [15] | Sharma, D., Farahbakhsh, N., Shastri, S. and Sharma, P. (2017) Biomarkers for Diagnosis of Neonatal Sepsis: A Literature Review. The Journal of Maternal-Fetal & Neonatal Medicine, 31, 1646-1659. https://doi.org/10.1080/14767058.2017.1322060 |
| [16] | Zhou, M., Cheng, S., Yu, J. and Lu, Q. (2015) Interleukin-8 for Diagnosis of Neonatal Sepsis: A Meta-Analysis. PLOS ONE, 10, e0127170. https://doi.org/10.1371/journal.pone.0127170 |
| [17] | Memar, M.Y., Alizadeh, N., Varshochi, M. and Kafil, H.S. (2017) Immunologic Biomarkers for Diagnostic of Early-Onset Neonatal Sepsis. The Journal of Maternal-Fetal & Neonatal Medicine, 32, 143-153. https://doi.org/10.1080/14767058.2017.1366984 |
| [18] | Chen, X., Liu, X., Dong, R., Zhang, D. and Qin, S. (2021) A Retrospective Observational Study of the Association between Plasma Levels of Interleukin 8 in 42 Patients with Sepsis-Induced Myocardial Dysfunction at a Single Center between 2017 and 2020. Medical Science Monitor, 27, e933065. https://doi.org/10.12659/msm.933065 |
| [19] | Wang, Q., Peng, G., Gan, L., Deng, Z., Zeng, L. and Deng, J. (2021) The Value of Interleukin-10 in the Early Diagnosis of Neonatal Sepsis: A Meta-Analysis. Pediatric Critical Care Medicine, 22, e492-e501. https://doi.org/10.1097/pcc.0000000000002706 |
| [20] | Xing, W., Wang, Y., Liu, J., Pei, J. and Yu, C. (2023) Role of Interleukins in the Detection of Neonatal Sepsis: A Network Meta-Analysis. Frontiers in Pediatrics, 11, Article 1267777. https://doi.org/10.3389/fped.2023.1267777 |
| [21] | Boskabadi, H. and Zakerihamidi, M. (2018) Evaluate the Diagnosis of Neonatal Sepsis by Measuring Interleukins: A Systematic Review. Pediatrics & Neonatology, 59, 329-338. https://doi.org/10.1016/j.pedneo.2017.10.004 |
| [22] | Khaertynov, K.S., Boichuk, S.V., Khaiboullina, S.F., Anokhin, V.A., Andreeva, A.A., Lombardi, V.C., et al. (2017) Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis. Journal of Immunology Research, 2017, Article ID: 8601063. https://doi.org/10.1155/2017/8601063 |
| [23] | Hibbert, J., Strunk, T., Simmer, K., Richmond, P., Burgner, D. and Currie, A. (2020) Plasma Cytokine Profiles in Very Preterm Infants with Late-Onset Sepsis. PLOS ONE, 15, e0232933. https://doi.org/10.1371/journal.pone.0232933 |
| [24] | Omran, A., Sobh, H., Abdalla, M.O., El-Sharkawy, S., Rezk, A.R. and Khashana, A. (2021) Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates. Journal of Immunology Research, 2021, Article ID: 4884537. https://doi.org/10.1155/2021/4884537 |
| [25] | Lv, B., Huang, J., Yuan, H., Yan, W., Hu, G. and Wang, J. (2014) Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis. Scientific World Journal, 2014, Article ID: 471463. |
| [26] | Hincu, M., Zonda, G., Stanciu, G.D., Nemescu, D. and Paduraru, L. (2020) Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis. Children, 7, Article 309. https://doi.org/10.3390/children7120309 |
| [27] | Cernada, M., Serna, E., Bauerl, C., Collado, M.C., Pérez-Martínez, G. and Vento, M. (2014) Genome-Wide Expression Profiles in Very Low Birth Weight Infants with Neonatal Sepsis. Pediatrics, 133, e1203-e1211. https://doi.org/10.1542/peds.2013-2552 |
| [28] | Varljen, T., Rakic, O., Sekulovic, G., Jekic, B., Maksimovic, N., Janevski, M.R., et al. (2019) Association between Tumor Necrosis Factor-α Promoter-308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants. The Tohoku Journal of Experimental Medicine, 247, 259-264. https://doi.org/10.1620/tjem.247.259 |
| [29] | Ye, C., Yano, H., Workman, C.J. and Vignali, D.A.A. (2021) Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases. Journal of Interferon & Cytokine Research, 41, 391-406. https://doi.org/10.1089/jir.2021.0147 |
| [30] | Cao, J., Xu, F., Lin, S., Tao, X., Xiang, Y., Lai, X., et al. (2015) IL-35 Is Elevated in Clinical and Experimental Sepsis and Mediates Inflammation. Clinical Immunology, 161, 89-95. https://doi.org/10.1016/j.clim.2015.08.016 |
| [31] | Hunter, C.A. and Kastelein, R. (2012) Interleukin-27: Balancing Protective and Pathological Immunity. Immunity, 37, 960-969. https://doi.org/10.1016/j.immuni.2012.11.003 |
| [32] | Hanna, W.J., Berrens, Z., Langner, T., Lahni, P. and Wong, H.R. (2015) Interleukin-27: A Novel Biomarker in Predicting Bacterial Infection among the Critically Ill. Critical Care, 19, Article No. 378. https://doi.org/10.1186/s13054-015-1095-2 |
| [33] | He, Y., Du, W.X., Jiang, H.y., Ai, Q., Feng, J., Liu, Z., et al. (2017) Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis. Shock, 47, 140-147. https://doi.org/10.1097/shk.0000000000000753 |
| [34] | Tosson, A.M.S., Koptan, D.M.T., Kamal, M. and Abd Elhady, M. (2022) Assessment of Serum Interleukin-27 and Mean Platelet Volume in Late-Onset Neonatal Sepsis. American Journal of Perinatology, 41, 1232-1237. |
| [35] | Wong, H.R., Lindsell, C.J., Lahni, P., Hart, K.W. and Gibot, S. (2013) Interleukin 27 as a Sepsis Diagnostic Biomarker in Critically Ill Adults. Shock, 40, 382-386. https://doi.org/10.1097/shk.0b013e3182a67632 |
| [36] | Wynn, J.L., Wilson, C.S., Hawiger, J., Scumpia, P.O., Marshall, A.F., Liu, J., et al. (2016) Targeting IL-17A Attenuates Neonatal Sepsis Mortality Induced by Il-18. Proceedings of the National Academy of Sciences of the United States of America, 113, E2627-E2635. https://doi.org/10.1073/pnas.1515793113 |
| [37] | Kaplanski, G. (2017) Interleukin‐18: Biological Properties and Role in Disease Pathogenesis. Immunological Reviews, 281, 138-153. https://doi.org/10.1111/imr.12616 |
| [38] | Li, X., Li, T., Dong, G., Wei, Y., Xu, Z. and Yang, J. (2022) Clinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction. Journal of Inflammation Research, 15, 6923-6930. https://doi.org/10.2147/jir.s393506 |
| [39] | Ge, Y., Huang, M. and Yao, Y. (2020) Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis. Frontiers in Immunology, 11, Article 1558. https://doi.org/10.3389/fimmu.2020.01558 |
| [40] | Rendon, J.L. and Choudhry, M.A. (2012) Th17 Cells: Critical Mediators of Host Responses to Burn Injury and Sepsis. Journal of Leukocyte Biology, 92, 529-538. https://doi.org/10.1189/jlb.0212083 |
| [41] | Liu, J., Cen, H., Ni, J., Zhang, M., Li, P., Yang, X., et al. (2014) Association of IL-21 Polymorphisms (Rs907715, Rs2221903) with Susceptibility to Multiple Autoimmune Diseases: A Meta-analysis. Autoimmunity, 48, 108-116. https://doi.org/10.3109/08916934.2014.944262 |
| [42] | Chakraborty, S., Kubatzky, K.F. and Mitra, D.K. (2019) An Update on Interleukin-9: From Its Cellular Source and Signal Transduction to Its Role in Immunopathogenesis. International Journal of Molecular Sciences, 20, Article 2113. https://doi.org/10.3390/ijms20092113 |
| [43] | Kaplan, M.H., Hufford, M.M. and Olson, M.R. (2015) The Development and in Vivo Function of T Helper 9 Cells. Nature Reviews Immunology, 15, 295-307. https://doi.org/10.1038/nri3824 |
| [44] | Ma, C.S., Tangye, S.G. and Deenick, E.K. (2010) Human Th9 Cells: Inflammatory Cytokines Modulate IL‐9 Production through the Induction of Il‐21. Immunology & Cell Biology, 88, 621-623. https://doi.org/10.1038/icb.2010.73 |
| [45] | Froeschle, G.M., Bedke, T., Boettcher, M., Huber, S., Singer, D. and Ebenebe, C.U. (2020) T Cell Cytokines in the Diagnostic of Early-Onset Sepsis. Pediatric Research, 90, 191-196. https://doi.org/10.1038/s41390-020-01248-x |
