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宫内感染与早产儿脑损伤的研究进展
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Abstract:
宫内感染是导致早产儿脑损伤的重要因素之一，近年来的研究揭示了其在导致早产儿脑损伤中的关键作用。宫内感染通过多种机制对早产儿的大脑发育造成影响，包括炎症反应、氧化应激和血脑屏障的破坏。现研究对宫内感染机制的深入理解，以及早期诊断和干预策略的探索显示通过抗感染、亚低温、促红细胞生成素、高压氧以及干细胞靶向治疗等可能有助于减少宫内感染对早产儿的负面影响。未来的研究需要进一步探索宫内感染与早产儿脑损伤之间的复杂关系，并研制更有效的干预措施，以改善早产儿的长期神经发育预后。
Intrauterine infection is one of the important factors leading to brain damage in premature infants, and recent studies have revealed its key role in causing brain damage in premature infants. Intrauterine infection affects the brain development of premature infants through various mechanisms, including inflammatory response, oxidative stress, and disruption of the blood-brain barrier. The in-depth understanding of the mechanism of intrauterine infection and the exploration of early diagnosis and intervention strategies have shown that anti-infection, hypothermia, erythropoietin, hyperbaric oxygen, and targeted stem cell therapy may help reduce the negative impact of intrauterine infection on premature infants. Future research needs to further explore the complex relationship between intrauterine infection and brain injury in premature infants, and develop more effective intervention measures to improve the long-term neurodevelopmental prognosis of premature infants.
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