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基于肠眼轴理论下干眼的治疗综述
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Abstract:
人体微生物群是指生活在人体不同部位的大量微生物(细菌、病毒和真菌)，包括肠道、口腔、皮肤和眼睛。最近的研究强调了肠道微生物群(GM)与眼部健康之间的潜在关联。在这方面，一些证据支持肠眼轴的存在参与了干眼症的发病机制。目前，干眼的发病率日愈增高，严重影响了人们的生活及工作质量。既有的治疗及其护理方法对于严重干眼症患者并不能让其十分满意。因此，了解肠道微生物群与这些眼部疾病之间的联系可能有助于开发新的治疗方法，如益生菌、益生元、共生菌或粪便微生物群移植，通过这些方法可以调节肠道微生物群，从而达到令人满意的治疗效果。
Human microbiota refers to a large number of microorganisms (bacteria, viruses and fungi) living in different parts of the human body, including intestines, mouth, skin and eyes. Recent studies have emphasized the potential relationship between intestinal microflora (GM) and eye health. In this regard, some evidence supports that the existence of intestinal axis is involved in the pathogenesis of dry eye. At present, the incidence of dry eye is increasing day by day, which seriously affects people’s life and work quality. The existing treatment and nursing methods are not very satisfactory for patients with severe dry eye. Therefore, understanding the relationship between intestinal microflora and these eye diseases may be helpful to develop new treatment methods, such as probiotics, prebiotics, symbiotic bacteria or fecal microflora transplantation, through which intestinal microflora can be adjusted, so as to achieve satisfactory treatment results.
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