Tamanu oil, derived from the nuts of Calophylluminophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.
References
[1]
Oge’, L.K., Broussard, A. and Marshall, M.D. (2019) Acne Vulgaris: Diagnosis and Treatment. American Family Physician, 100, 475-484.
[2]
Sutaria, A.H., Masood, S., Saleh, H.M. and Schlessinger, J. (2024) Acne Vulgaris. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459173/
[3]
Pribowo, A., Girish, J., Gustiananda, M., Nandhira, R.G. and Hartrianti, P. (2021) Potential of Tamanu (Calophylluminophyllum) Oil for Atopic Dermatitis Treatment. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID: 6332867. https://doi.org/10.1155/2021/6332867
[4]
Poljšak, N., Kreft, S. and Kočevar Glavač, N. (2019) Vegetable Butters and Oils in Skin Wound Healing: Scientific Evidence for New Opportunities in Dermatology. Phytotherapy Research, 34, 254-269. https://doi.org/10.1002/ptr.6524
[5]
Nguyen, V., Truong, C., Nguyen, B.C.Q., Vo, T.V., Dao, T., Nguyen, V., et al. (2017) Anti-Inflammatory and Wound Healing Activities of Calophyllolide Isolated from Calophylluminophyllum Linn. PLOS ONE, 12, e0185674. https://doi.org/10.1371/journal.pone.0185674
[6]
Léguillier, T., Lecsö-Bornet, M., Lémus, C., Rousseau-Ralliard, D., Lebouvier, N., Hnawia, E., et al. (2015) The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophylluminophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds. PLOS ONE, 10, e0138602. https://doi.org/10.1371/journal.pone.0138602
[7]
Cassien, M., Mercier, A., Thétiot-Laurent, S., Culcasi, M., Ricquebourg, E., Asteian, A., et al. (2021) Improving the Antioxidant Properties of Calophylluminophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts. Antioxidants, 10, Article No. 199. https://doi.org/10.3390/antiox10020199
[8]
Saxena, R., Nath, R., Palit, G., Nigam, S. and Bhargava, K. (1982) Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability. Planta Medica, 44, 246-248. https://doi.org/10.1055/s-2007-971459
[9]
Ghashghaii, A., Hashemnia, M., Nikousefat, Z., Zangeneh, M.M. and Zangeneh, A. (2017) Wound Healing Potential of Methanolic Extract of Scrophularia Striata in Rats. Pharmaceutical Sciences, 23, 256-263. https://doi.org/10.15171/ps.2017.38
[10]
Erdogan, S.S., Gur, T.F., Terzi, N.K. and Dogan, B. (2021) Evaluation of the Cutaneous Wound Healing Potential of Tamanu Oil in Wounds Induced in Rats. Journal of Wound Care, 30, Vi-Vx. https://doi.org/10.12968/jowc.2021.30.sup9a.v
[11]
Dweck, A.C. and Meadows, T. (2002) Tamanu (Calophylluminophyllum)—The African, Asian, Polynesian and Pacific Panacea. International Journal of Cosmetic Science, 24, 341-348. https://doi.org/10.1046/j.1467-2494.2002.00160.x
[12]
Krishnappa, M., Abraham, S., Furtado, S.C., Krishnamurthy, S., Rifaya, A., Asiri, Y.I., et al. (2024) An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent. Pharmaceuticals, 17, Article No. 102. https://doi.org/10.3390/ph17010102
[13]
Ansel, J., Lupo, E., Mijouin, L., Guillot, S., Butaud, J., Ho, R., et al. (2016) Biological Activity of Polynesian Calophylluminophyllum Oil Extract on Human Skin Cells. Planta Medica, 82, 961-966. https://doi.org/10.1055/s-0042-108205
[14]
Cruz, S., Vecerek, N. and Elbuluk, N. (2023) Targeting Inflammation in Acne: Current Treatments and Future Prospects. American Journal of Clinical Dermatology, 24, 681-694. https://doi.org/10.1007/s40257-023-00789-1
[15]
Fabbrocini, G., Annunziata, M.C., D’Arco, V., De Vita, V., Lodi, G., Mauriello, M.C., et al. (2010) Acne Scars: Pathogenesis, Classification and Treatment. Dermatology Research and Practice, 2010, Article ID: 893080. https://doi.org/10.1155/2010/893080
[16]
Raharivelomanana, P., Ansel, J., Lupo, E., Mijouin, L., Guillot, S., Butaud, J., et al. (2018) Tamanu Oil and Skin Active Properties: From Traditional to Modern Cosmetic Uses. OCL, 25, D504. https://doi.org/10.1051/ocl/2018048
[17]
McCusker, M.M. and Grant-Kels, J.M. (2010) Healing Fats of the Skin: The Structural and Immunologic Roles of the Ω-6 and Ω-3 Fatty Acids. Clinics in Dermatology, 28, 440-451. https://doi.org/10.1016/j.clindermatol.2010.03.020
[18]
Ruangsuriya, J., Sichaem, J., Tantraworasin, A., Saeteng, S., Wongmaneerung, P., Inta, A., et al. (2023) Phytochemical Profiles and Anticancer Effects of Calophylluminophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Cancers. Scientifica, 2023, Article ID: 6613670. https://doi.org/10.1155/2023/6613670
[19]
Addor, F.A.S. (2017) Antioxidants in Dermatology. Anais Brasileiros de Dermatologia, 92, 356-362. https://doi.org/10.1590/abd1806-4841.20175697
[20]
Čižmárová, B., Hubková, B., Tomečková, V. and Birková, A. (2023) Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases. International Journal of Molecular Sciences, 24, Article No. 6324. https://doi.org/10.3390/ijms24076324
[21]
Zalewski, J., Mączyńska, J., Bieżuńska-Kusiak, K., Kulbacka, J., Choromańska, A., Przestrzelska, M., et al. (2019) Calophylluminophyllum in Vaginitis Treatment: Stimulated by Electroporation with an in Vitro Approach. Advances in Clinical and Experimental Medicine, 28, 223-228. https://doi.org/10.17219/acem/87045
[22]
Valerón-Almazán, P., Gómez-Duaso, A.J., Santana-Molina, N., García-Bello, M.A. and Carretero, G. (2015) Evolution of Post-Surgical Scars Treated with Pure Rosehip Seed Oil. Journal of Cosmetics, Dermatological Sciences and Applications, 5, 161-167. https://doi.org/10.4236/jcdsa.2015.52019
[23]
Vasam, M., Korutla, S. and Bohara, R.A. (2023) Acne Vulgaris: A Review of the Pathophysiology, Treatment, and Recent Nanotechnology Based Advances. Biochemistry and Biophysics Reports, 36, Article ID: 101578. https://doi.org/10.1016/j.bbrep.2023.101578
[24]
Le Coz, C. (2004) Allergic Contact Dermatitis from Tamanu Oil (Calophylluminophyllum, Calophyllumtacamahaca). Contact Dermatitis, 51, 216-217. https://doi.org/10.1111/j.0105-1873.2004.0424h.x
[25]
Ma, N., Liu, X., Yang, Y., Li, J., Mohamed, I., Liu, G., et al. (2015) Preventive Effect of Aspirin Eugenol Ester on Thrombosis in Κ-Carrageenan-Induced Rat Tail Thrombosis Model. PLOS ONE, 10, e0133125. https://doi.org/10.1371/journal.pone.0133125
[26]
Zia, K. (2014) Emotional State and Psychological Well-Being of Dermatological Patients. Open Access Library Journal, 1, e434. https://doi.org/10.4236/oalib.1100434
[27]
Ginigini, J., Lecellier, G.J., Nicolas, M., Nour, M., Hnawia, E., Lebouvier, N., et al. (2019) Chemodiversity of Calophylluminophyllum L. Oil Bioactive Components Related to Their Specific Geographical Distribution in the South Pacific Region. PeerJ, 7, e6896. https://doi.org/10.7717/peerj.6896
[28]
Nurzyńska-Wierdak, R., Pietrasik, D. and Walasek-Janusz, M. (2022) Essential Oils in the Treatment of Various Types of Acne—A Review. Plants, 12, Article No. 90. https://doi.org/10.3390/plants12010090
