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Pharmacological Treatment for Atrial Fibrillation
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Abstract:
Cardiac arrhythmias are probably more common in horses than in any other domestic animal species where poor performance and exercise intolerance is the most frequent clinical complaint. Atrial fibrillation is a type of cardiac arrhythmia that appears as a common finding during medical examinations in humans, large breed dogs and horses. Clinical presentations are of a particular value in racehorses in high performing activities. Atrial fibrillation is characterized by an irregular heart rhythm, secondary to a primary disease or without any sign of comorbidity. The generation and maintenance of Atrial Fibrillation requires a substrate. Some breeds have a genetic predisposition to developing Atrial Fibrillation. Most cases of Atrial Fibrillation are of the paroxysmal type and self-regulate within a few hours to days without the need for treatment. The focus of this study is on the arrhythmic agents that are used for the treatment of Atrial Fibrillation, therefore other arrhythmic agents may not be included, or are included to demonstrate their effect on increasing, inhibiting or decreasing efficacy when used together with medications for the treatment of Atrial Fibrillation. The “working horse” for the pharmacological treatment of Atrial Fibrillation is Quinidine.
| [1] | Saljic, A., Jespersen, T. and Buhl, R. (2021) Anti-Arrhythmic Investigations in Large Animal Models of Atrial Fibrillation. British Journal of Pharmacology, 179, 838-858. https://doi.org/10.1111/bph.15417 |
| [2] | Côté, E. (2010) Feline Arrhythmias: An Update. Veterinary Clinics of North America: Small Animal Practice, 40, 643-650. https://doi.org/10.1016/j.cvsm.2010.04.002 |
| [3] | Jackson, B.L., Lehmkuhl, L.B. and Adin, D.B. (2014) Heart Rate and Arrhythmia Frequency of Normal Cats Compared to Cats with Asymptomatic Hypertrophic Cardiomyopathy. Journal of Veterinary Cardiology, 16, 215-225. https://doi.org/10.1016/j.jvc.2014.10.001 |
| [4] | Buchanan, J.W. (1965) Spontaneous Arrhythmias and Conduction Disturbances in Domestic Animals. Annals of the New York Academy of Sciences, 127, 224-238. https://doi.org/10.1111/j.1749-6632.1965.tb49405.x |
| [5] | Buhl, R., Nissen, S.D., Winther, M.L.K., Poulsen, S.K., Hopster-Iversen, C., Jespersen, T., et al. (2020) Implantable Loop Recorders Can Detect Paroxysmal Atrial Fibrillation in Standardbred Racehorses with Intermittent Poor Performance. Equine Veterinary Journal, 53, 955-963. https://doi.org/10.1111/evj.13372 |
| [6] | Deegen, E. and Buntenkötter, S. (1976) Behaviour of the Heart Rate of Horses with Auricular Fibrillation during Exercise and after Treatment. Equine Veterinary Journal, 8, 26-29. https://doi.org/10.1111/j.2042-3306.1976.tb03278.x |
| [7] | Deem, D.A. and Fregin, G.F. (1982) Atrial Fibrillation in Horses: A Review of 106 Clinical Cases, with Consideration of Prevalence, Clinical Signs, and Prognosis. Journal of the American Veterinary Medical Association, 180, 261-265. |
| [8] | Physick-Sheard, P.W. and McGurrin, M.K.J. (2010) Ventricular Arrhythmias during Race Recovery in Standardbred Racehorses and Associations with Autonomic Activity. Journal of Veterinary Internal Medicine, 24, 1158-1166. https://doi.org/10.1111/j.1939-1676.2010.0553.x |
| [9] | Premont, A., Balthes, S., Marr, C.M. and Jeevaratnam, K. (2021) Fundamentals of Arrhythmogenic Mechanisms and Treatment Strategies for Equine Atrial Fibrillation. Equine Veterinary Journal, 54, 262-282. https://doi.org/10.1111/evj.13518 |
| [10] | Holmes, J.R. (1987) Cardiac Arrhythmias on the Racecourse. In: Gillespie, J.R. and Robinson, H.E., Eds., Equine Exercise Physiology 2, ICEEP Publications, 781. |
| [11] | Holmes, J.R., Henigan, M., Williams, R.B. and Witherington, D.H. (1986) Paroxysmal Atrial Fibrillation in Racehorses. Equine Veterinary Journal, 18, 37-42. https://doi.org/10.1111/j.2042-3306.1986.tb03533.x |
| [12] | Broojmans, A.W.M. (1957) Electrocardiography in Horses and Cattle. Uitgeverij Cantecleer. |
| [13] | DiFrancesco, D. (2010) The Role of the Funny Current in Pacemaker Activity. Circulation Research, 106, 434-446. https://doi.org/10.1161/circresaha.109.208041 |
| [14] | Glazier, D.B., Nicholson, J.A. and Kelly, W.R. (1959) Atrial Fibrillation in the Horse. Irish Veterinary Journal, 13, 47-55. |
| [15] | Jose-Cunilleras, E., Young, L.E., Newton, J.R. and Marlin, D.J. (2006) Cardiac Arrhythmias during and after Treadmill Exercise in Poorly Performing Thoroughbred Racehorses. Equine Veterinary Journal, 38, 163-170. https://doi.org/10.1111/j.2042-3306.2006.tb05534.x |
| [16] | Ohmura, H., Hiraga, A., Takahashi, T., Kai, M. and Jones, J.H. (2003) Risk Factors for Atrial Fibrillation during Racing in Slow-Finishing Horses. Journal of the American Veterinary Medical Association, 223, 84-88. https://doi.org/10.2460/javma.2003.223.84 |
| [17] | Leroux, A.A., Detilleux, J., Sandersen, C.F., Borde, L., Houben, R.M.A.C., Al Haidar, A., et al. (2013) Prevalence and Risk Factors for Cardiac Diseases in a Hospital-Based Population of 3, 434 Horses (1994-2011). Journal of Veterinary Internal Medicine, 27, 1563-1570. https://doi.org/10.1111/jvim.12197 |
| [18] | Andrade, J., Khairy, P., Dobrev, D. and Nattel, S. (2014) The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships among Clinical Features, Epidemiology, and Mechanisms. Circulation Research, 114, 1453-1468. https://doi.org/10.1161/circresaha.114.303211 |
| [19] | Antzelevitch, C. and Burashnikov, A. (2013) Mechanisms of Cardiac Arrhythmia. In: Gussak, I. and Antzelevitch, C., Eds., Electrical Diseases of the Heart, Springer, 93-128. https://doi.org/10.1007/978-1-4471-4881-4_6 |
| [20] | Wit, A.L. and Cranefield, P.F. (1977) Triggered and Automatic Activity in the Canine Coronary Sinus. Circulation Research, 41, 434-445. https://doi.org/10.1161/01.res.41.4.434 |
| [21] | Menaut, P., Bélanger, M.C., Beauchamp, G., Ponzio, N.M. and Moïse, N.S. (2005) Atrial Fibrillation in Dogs with and without Structural or Functional Cardiac Disease: A Retrospective Study of 109 Cases. Journal of Veterinary Cardiology, 7, 75-83. https://doi.org/10.1016/j.jvc.2005.07.002 |
| [22] | Nattel, S., Burstein, B. and Dobrev, D. (2008) Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications. Circulation: Arrhythmia and Electrophysiology, 1, 62-73. https://doi.org/10.1161/circep.107.754564 |
| [23] | Everett, T.H., Li, H., Mangrum, J.M., McRury, I.D., Mitchell, M.A., Redick, J.A., et al. (2000) Electrical, Morphological, and Ultrastructural Remodeling and Reverse Remodeling in a Canine Model of Chronic Atrial Fibrillation. Circulation, 102, 1454-1460. https://doi.org/10.1161/01.cir.102.12.1454 |
| [24] | Vischer, A.S., Connolly, D.J., Coats, C.J., Fuentes, V.L., McKenna, W.J., Castelletti, S. and Pantazis, A.A. (2017) Arrhythmogenic Right Ventricular Cardiomyopathy in Boxer Dogs: The Diagnosis as a Link to the Human Disease. Acta Myologica, 36, 135-150. |
| [25] | Waldo, A.L. and Wit, A.L. (1993) Mechanisms of Cardiac Arrhythmias. The Lancet, 341, 1189-1193. https://doi.org/10.1016/0140-6736(93)91012-b |
| [26] | Verheyen, T., Decloedt, A., van der Vekens, N., Sys, S., De Clercq, D. and van Loon, G. (2012) Ventricular Response during Lungeing Exercise in Horses with Lone Atrial Fibrillation. Equine Veterinary Journal, 45, 309-314. https://doi.org/10.1111/j.2042-3306.2012.00653.x |
| [27] | Amada, A., Senta, T., Kubo, K., Ohishi, S. and Kiryyu, K. (1974) Atrial Fibrillation Histopathological in the Horse: Clinical Histopathological Studies of Two Cases. I. Clinical Study. Experimental Reports of Equine Health Laboratory, 1974, 51-69. |
| [28] | Machida, N., Yasuda, J. and Too, K. (1989) Three Cases of Paroxysmal Atrial Fibrillation in the Thoroughbred Newborn Foal. Equine Veterinary Journal, 21, 66-68. https://doi.org/10.1111/j.2042-3306.1989.tb02091.x |
| [29] | Nath, L.C., Elliott, A.D., Weir, J., Curl, P., Rosanowski, S.M. and Franklin, S. (2021) Incidence, Recurrence, and Outcome of Postrace Atrial Fibrillation in Thoroughbred Horses. Journal of Veterinary Internal Medicine, 35, 1111-1120. https://doi.org/10.1111/jvim.16063 |
| [30] | Ryan, N., Marr, C.M. and McGladdery, A.J. (2010) Survey of Cardiac Arrhythmias during Submaximal and Maximal Exercise in Thoroughbred Racehorses. Equine Veterinary Journal, 37, 265-268. https://doi.org/10.2746/0425164054530713 |
| [31] | Slack, J., Boston, R.C., Soma, L.R. and Reef, V.B. (2014) Occurrence of Cardiac Arrhythmias in standardbred Racehorses. Equine Veterinary Journal, 47, 398-404. https://doi.org/10.1111/evj.12299 |
| [32] | Barbesgaard, L., Buhl, R. and Meldgaard, C. (2010) Prevalence of Exercise-Associated Arrhythmias in Normal Performing Dressage Horses. Equine Veterinary Journal, 42, 202-207. https://doi.org/10.1111/j.2042-3306.2010.00223.x |
| [33] | Williams, R.B., Harkins, L.S., Hammond, C.J. and Wood, J.L.N. (2001) Racehorse Injuries, Clinical Problems and Fatalities Recorded on British Racecourses from Flat Racing and National Hunt Racing during 1996, 1997 and 1998. Equine Veterinary Journal, 33, 478-486. https://doi.org/10.2746/042516401776254808 |
| [34] | Maltsev, V.A., Vinogradova, T.M. and Lakatta, E.G. (2006) The Emergence of a General Theory of the Initiation and Strength of the Heartbeat. Journal of Pharmacological Sciences, 100, 338-369. https://doi.org/10.1254/jphs.cr0060018 |
| [35] | McGuirk, S.M. and Muir, W.W. (1985) Diagnosis and Treatment of Cardiac Arrhythmias. Veterinary Clinics of North America: Equine Practice, 1, 353-370. https://doi.org/10.1016/s0749-0739(17)30760-5 |
| [36] | McGurrin, K. (2015) The Diagnosis and Management of Atrial Fibrillation in the Horse. Veterinary Medicine: Research and Reports, 6, 83-90. https://doi.org/10.2147/vmrr.s46304 |
| [37] | Pedro, B., Fontes-Sousa, A.P. and Gelzer, A.R. (2020) Diagnosis and Management of Canine Atrial Fibrillation. The Veterinary Journal, 265, Article ID: 105549. https://doi.org/10.1016/j.tvjl.2020.105549 |
| [38] | Alessi, R., Nusynowitz, M., Abildskov, J.A. and Moe, G.K. (1958) Nonuniform Distribution of Vagal Effects on the Atrial Refractory Period. American Journal of Physiology-Legacy Content, 194, 406-410. https://doi.org/10.1152/ajplegacy.1958.194.2.406 |
| [39] | Boyden, P.A. (1996) Cellular Electrophysiologic Basis of Cardiac Arrhythmias. The American Journal of Cardiology, 78, 4-11. https://doi.org/10.1016/s0002-9149(96)00447-x |
| [40] | Mangoni, M.E. and Nargeot, J. (2008) Genesis and Regulation of the Heart Automaticity. Physiological Reviews, 88, 919-982. https://doi.org/10.1152/physrev.00018.2007 |
| [41] | Marr, C.M. and Bowen, I.M. (2010) Cardiology of the Horse. Second Edition, Saunders/Elsevier. |
| [42] | Crijns, H.J.G.M., Panhuyzen-Goedkoop, N.M., Kingma, J.H., Wilde, A.A.M., Al-lessie, M.A., Bennekers, J.H., van den Berg, M.P., Bosker, H.A., van Gelder, I.C., Gosselink, A.T.M., Kamp, O. and Smeets, J.L.R.M. (1999) De Nederlandse richtlijnen van boezemfibrilleren. Guidelines in Cardiology, 6, 486-511. |
| [43] | Noble, D. (1979) The Initiation of the Heartbeat. 2nd Edition, Oxford University Press. |
| [44] | Cushing, D.J., Cooper, W.D., Gralinski, M.R., Lipicky, R.J., Kudenchuk, P.J. and Kowey, P.R. (2009) Comparison of the Cardiac Electrophysiology and General Toxicology of Two Formulations of Intravenous Amiodarone in Dogs. Cardiovascular Toxicology, 9, 126-133. https://doi.org/10.1007/s12012-009-9044-4 |
| [45] | Dangman, K.H. and Boyden, P.A. (1988) Cellular Mechanisms of Cardiac Arrhythmias. In: Fox, P.R., Ed., Canine and Feline Cardiology, Churchill Livingstone, 269-287. |
| [46] | Kaese, S. and Verheule, S. (2012) Cardiac Electrophysiology in Mice: A Matter of Size. Frontiers in Physiology, 3, Article 345. https://doi.org/10.3389/fphys.2012.00345 |
| [47] | De Clercq, D., Decloedt, A., Sys, S.U., Verheyen, T., Van Der Vekens, N. and van Loon, G. (2014) Atrial Fibrillation Cycle Length and Atrial Size in Horses with and without Recurrence of Atrial Fibrillation after Electrical Cardioversion. Journal of Veterinary Internal Medicine, 28, 624-629. https://doi.org/10.1111/jvim.12322 |
| [48] | Physick-Sheard, P., Kraus, M., Basrur, P., McGurrin, K., Kenney, D. and Schenkel, F. (2014) Breed Predisposition and Heritability of Atrial Fibrillation in the Standardbred Horse: A Retrospective Case-Control Study. Journal of Veterinary Cardiology, 16, 173-184. https://doi.org/10.1016/j.jvc.2014.03.006 |
| [49] | Wakili, R., Voigt, N., Kääb, S., Dobrev, D. and Nattel, S. (2011) Recent Advances in the Molecular Pathophysiology of Atrial Fibrillation. Journal of Clinical Investigation, 121, 2955-2968. https://doi.org/10.1172/jci46315 |
| [50] | Baruscotti, M., Bucchi, A. and DiFrancesco, D. (2005) Physiology and Pharmacology of the Cardiac Pacemaker (“Funny”) Current. Pharmacology & Therapeutics, 107, 59-79. https://doi.org/10.1016/j.pharmthera.2005.01.005 |
| [51] | Lakatta, E.G. and DiFrancesco, D. (2009) What Keeps Us Ticking: A Funny Current, a Calcium Clock, or Both? Journal of Molecular and Cellular Cardiology, 47, 157-170. https://doi.org/10.1016/j.yjmcc.2009.03.022 |
| [52] | Yeh, Y., Burstein, B., Qi, X.Y., Sakabe, M., Chartier, D., Comtois, P., et al. (2009) Funny Current Downregulation and Sinus Node Dysfunction Associated with Atrial Tachyarrhythmia: A Molecular Basis for Tachycardia-Bradycardia Syndrome. Circulation, 119, 1576-1585. https://doi.org/10.1161/circulationaha.108.789677 |
| [53] | Lakatta, E.G. (2010) A Paradigm Shift for the Heart’s Pacemaker. Heart Rhythm, 7, 559-564. https://doi.org/10.1016/j.hrthm.2009.12.013 |
| [54] | Bucchi, A., Baruscotti, M. and DiFrancesco, D. (2002) Current-Dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine. The Journal of General Physiology, 120, 1-13. https://doi.org/10.1085/jgp.20028593 |
| [55] | DiFrancesco, D. (1985) The Cardiac Hyperpolarizing-Activated Current, If. Origins and Developments. Progress in Biophysics and Molecular Biology, 46, 163-183. https://doi.org/10.1016/0079-6107(85)90008-2 |
| [56] | Milanesi, R., Baruscotti, M., Gnecchi-Ruscone, T. and DiFrancesco, D. (2006) Familial Sinus Bradycardia Associated with a Mutation in the Cardiac Pacemaker Channel. New England Journal of Medicine, 354, 151-157. https://doi.org/10.1056/nejmoa052475 |
| [57] | Bhuiyan, Z.A., van den Berg, M.P., van Tintelen, J.P., Bink-Boelkens, M.T.E., Wiesfeld, A.C.P., Alders, M., et al. (2007) Expanding Spectrum of Human RYR2-Related Disease: New Electrocardiographic, Structural, and Genetic Features. Circulation, 116, 1569-1576. https://doi.org/10.1161/circulationaha.107.711606 |
| [58] | Yue, L., Feng, J., Gaspo, R., Li, G., Wang, Z. and Nattel, S. (1997) Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation. Circulation Research, 81, 512-525. https://doi.org/10.1161/01.res.81.4.512 |
| [59] | Kiryu, K., Amada, A., Kaneko, K. and Hiroshi, S. (1974) Atrial Fibrillation in the Horse: Clinical and Histopathological Studies of Two Cases, II: Formal Pathogenesis. Experimental Reports of Equine Health Laboratory, 70-86. https://web.archive.org/web/20220511074248id_/ |
| [60] | Botts, R.P., Patterson, D.F., Detweiler, D.K. and Hubben, K. (1961) Spontaneous Abnormal Cardiac Arrhythmias and Conduction Disturbances in the Dog. A Clinical and Pathologic Study of 3, 000 Dogs. American Journal of Veterinary Research, 22, 355-369. |
| [61] | Chen, S., Hsieh, M., Tai, C., Tsai, C., Prakash, V.S., Yu, W., et al. (1999) Initiation of Atrial Fibrillation by Ectopic Beats Originating from the Pulmonary Veins: Electrophysiological Characteristics, Pharmacological Responses, and Effects of Radiofrequency Ablation. Circulation, 100, 1879-1886. https://doi.org/10.1161/01.cir.100.18.1879 |
| [62] | Cranefield, P.F., Wit, A.L. and Hoffman, B.F. (1973) Genesis of Cardiac Arrhythmias. Circulation, 47, 190-204. https://doi.org/10.1161/01.cir.47.1.190 |
| [63] | Decloedt, A., Van Steenkiste, G., Vera, L., Buhl, R. and van Loon, G. (2020) Atrial Fibrillation in Horses Part 1: Pathophysiology. The Veterinary Journal, 263, Article ID: 105521. https://doi.org/10.1016/j.tvjl.2020.105521 |
| [64] | Voigt, N., Heijman, J., Wang, Q., Chiang, D.Y., Li, N., Karck, M., et al. (2014) Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients with Paroxysmal Atrial Fibrillation. Circulation, 129, 145-156. https://doi.org/10.1161/circulationaha.113.006641 |
| [65] | Amada, A. and Kurita, H. (1975) Five Cases of Paroxysmal Atrial Fibrillation in the Racehorse. Experimental Reports of Equine Health Laboratory, 12, 89-100. https://www.jstage.jst.go.jp |
| [66] | Holmes, J.R., Darke, P.G.G. and Else, R.W. (1969) Atrial Fibrillation in the Horse. Equine Veterinary Journal, 1, 212-222. https://doi.org/10.1111/j.2042-3306.1969.tb03375.x |
| [67] | Rose, R.J. and Davis, P.E. (1977) Paroxysmal Atrial Fibrillation in a Racehorse. Australian Veterinary Journal, 53, 545-549. https://doi.org/10.1111/j.1751-0813.1977.tb07943.x |
| [68] | Detweiler, D.K. (1955) Auricular Fibrillation in Horses. JAVMA: Journal of the American Veterinary Medical Association, 126, 47-50. |
| [69] | van den Hoven, R., Schwarz, B. and Hanka, J. (2015) Paroxysmales Vorhofflimmern und klinisch reversibles Cor pulmonale bei einem Pferd mit komplizierter rezidivierender Atemwegsobstruktion. Tierärztliche Praxis Ausgabe G: Großtiere/Nutztiere, 43, 109-114. https://doi.org/10.15653/tpg-140075 |
| [70] | Shaftoe, S. and McGuirk, S.M. (1987) Valvular Insufficiency in a Horse with Atrial Fibrillation. Compendium: Continuing Education for Veterinarians, 9, 203-209. |
| [71] | Reef, V.B., Levitan, C.W. and Spencer, P.A. (1988) Factors Affecting Prognosis and Conversion in Equine Atrial Fibrillation. Journal of Veterinary Internal Medicine, 2, 1-6. https://doi.org/10.1111/j.1939-1676.1988.tb01970.x |
| [72] | Else, R.W. and Holmes, J.R. (1971) Pathological Changes in Atrial Fibrillation in the Horse. Equine Veterinary Journal, 3, 56-64. https://doi.org/10.1111/j.2042-3306.1971.tb04441.x |
| [73] | Nattel, S. and Dobrev, D. (2016) Electrophysiological and Molecular Mechanisms of Paroxysmal Atrial Fibrillation. Nature Reviews Cardiology, 13, 575-590. https://doi.org/10.1038/nrcardio.2016.118 |
| [74] | Comtois, P., Kneller, J. and Nattel, S. (2005) Of Circles and Spirals: Bridging the Gap between the Leading Circle and Spiral Wave Concepts of Cardiac Reentry. EP Europace, 7, S10-S20. https://doi.org/10.1016/j.eupc.2005.05.011 |
| [75] | Wyse, D.G., Van Gelder, I.C., Ellinor, P.T., Go, A.S., Kalman, J.M., Narayan, S.M., et al. (2014) Lone Atrial Fibrillation. Journal of the American College of Cardiology, 63, 1715-1723. https://doi.org/10.1016/j.jacc.2014.01.023 |
| [76] | Galal Azzam, H.A. (2013) Thrombogenesis in Atrial Fibrillation. In: Liu, T., Ed., Atrial Fibrillation-Mechanisms and Treatment, InTech, 127-151. |
| [77] | January, C.T., Wann, L.S., Alpert, J.S., Calkins, H., Cigarroa, J.E., Cleveland, J.C., et al. (2014) 2014 AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation: Executive Summary. Circulation, 130, 2071-2104. https://doi.org/10.1161/cir.0000000000000040 |
| [78] | Lévy, S. (2000) Classification System of Atrial Fibrillation. Current Opinion in Cardiology, 15, 54-57. https://doi.org/10.1097/00001573-200001000-00007 |
| [79] | Levy, S., Novella, P., Ricard, P. and Paganelli, F. (1995) Paroxysmal a Trial Fibrillation. Journal of Cardiovascular Electrophysiology, 6, 69-74. https://doi.org/10.1111/j.1540-8167.1995.tb00758.x |
| [80] | Zipes, D.P. (1997) Management of Cardiac Arrhythmias: Pharmacological, Electrical and Surgical Techniques. In: Braunwald, E., Ed., Heart Disease: A Textbook of Cardiovascular Medicine (5th edition), WB Saunders, 593-639. |
| [81] | Allessie, M.A., Boyden, P.A., Camm, A.J., Kléber, A.G., Lab, M.J., Legato, M.J., et al. (2001) Pathophysiology and Prevention of Atrial Fibrillation. Circulation, 103, 769-777. https://doi.org/10.1161/01.cir.103.5.769 |
| [82] | Gelberg, H.B., Smetzer, D.L. and Foreman, J.H. (1991) Pulmonary Hypertension as a Cause of Atrial Fibrillation in Young Horses: Four Cases (1980-1989). Journal of the American Veterinary Medical Association, 198, 679-682. https://doi.org/10.2460/javma.1991.198.04.679 |
| [83] | Morillo, C.A., Klein, G.J., Jones, D.L. and Guiraudon, C.M. (1995) Chronic Rapid Atrial Pacing. Structural, Functional, and Electrophysiological Characteristics of a new Model of Sustained Atrial Fibrillation Circulation, 91, 1588-1595. https://doi.org/10.1161/01.cir.91.5.1588 |
| [84] | Reef, V.B., Bonagura, J., Buhl, R., McGurrin, M.K.J., Schwarzwald, C.C., van Loon, G., et al. (2014) Recommendations for Management of Equine Athletes with Cardiovascular Abnormalities. Journal of Veterinary Internal Medicine, 28, 749-761. https://doi.org/10.1111/jvim.12340 |
| [85] | Physick-Sheard, P.W., Marlin, D.J., Thornhill, R. and Schroter, R.C. (2000) Frequency Domain Analysis of Heart Rate Variability in Horses at Rest and during Exercise. Equine Veterinary Journal, 32, 253-262. https://doi.org/10.2746/042516400776563572 |
| [86] | Bellet, S. (1946) Clinical Disorders of the Heart Beat. Clinics, 5, 190-234. |
| [87] | Reef, V.B., Reimer, J.M. and Spencer, P.A. (1995) Treatment of Atrial Fibrillation in Horses: New Perspectives. Journal of Veterinary Internal Medicine, 9, 57-67. https://doi.org/10.1111/j.1939-1676.1995.tb03274.x |
| [88] | Glazier, D.B. and Kavanagh, J.F. (1967) An Unusual Case of Atrial Fibrillation in a Racing Thoroughbred Filly. Irish Veterinary Journal, 21, 107-110. |
| [89] | Machida, N. and Kiryu, K. (2001) Cardiac Lesions in Dairy Cows with Idiopathic Atrial Fibrillation. Journal of Veterinary Medical Science, 63, 873-878. https://doi.org/10.1292/jvms.63.873 |
| [90] | Stewart, G., Fulton, L. and McKellar, C. (1990) Idiopathic Atrial Fibrillation in a Champion Standardised Racehorse. Australian Veterinary Journal, 67, 187-191. https://doi.org/10.1111/j.1751-0813.1990.tb07752.x |
| [91] | Burstein, B. and Nattel, S. (2008) Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation. Journal of the American College of Cardiology, 51, 802-809. https://doi.org/10.1016/j.jacc.2007.09.064 |
| [92] | Lau, D.H., Linz, D., Schotten, U., Mahajan, R., Sanders, P. and Kalman, J.M. (2017) Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis. Heart, Lung and Circulation, 26, 887-893. https://doi.org/10.1016/j.hlc.2017.05.119 |
| [93] | Burns, J.J., MacMillan, K.M. and John, E.E. (2022) Retrospective Review of Atrial Fibrillation in Standardbred Racehorses at a Tertiary Care Facility in Atlantic Canada. The Canadian Veterinary Journal, 63, 1051-1056. |
| [94] | Roos, J. (1924) Auricular Fibrillation in Domestic Animals. Heart, 11, 1-7. |
| [95] | Morris, D.D. and Fregin, G.F. (1982) Atrial Fibrillation in Horses: Factors Associated with Response to Quinidine Sulfate in 77 Clinical Cases. The Cornell Veterinarian, 72, 339-349. |
| [96] | Van Steenkiste, G., Vera, L., Decloedt, A., Schauvliege, S., Boussy, T. and van Loon, G. (2020) Endocardial Electro-Anatomic Mapping in Healthy Horses: Normal Sinus Impulse Propagation in the Left and Right Atrium and the Ventricles. The Veterinary Journal, 258, Article ID: 105452. https://doi.org/10.1016/j.tvjl.2020.105452 |
| [97] | Wijffels, M.C.E.F., Kirchhof, C.J.H.J., Dorland, R. and Allessie, M.A. (1995) Atrial Fibrillation Begets Atrial Fibrillation. A Study in Awake Chronically Instrumented Goats. Circulation, 92, 1954-1968. https://doi.org/10.1161/01.cir.92.7.1954 |
| [98] | Broux, B., De Clercq, D., Decloedt, A., Ven, S., Vera, L., van Steenkiste, G., et al. (2017) Heart Rate Variability Parameters in Horses Distinguish Atrial Fibrillation from Sinus Rhythm before and after Successful Electrical Cardioversion. Equine Veterinary Journal, 49, 723-728. https://doi.org/10.1111/evj.12684 |
| [99] | Evans, D.L. (1985) Cardiovascular Adaptations to Exercise and Training. Veterinary Clinics of North America: Equine Practice, 1, 513-531. https://doi.org/10.1016/s0749-0739(17)30748-4 |
| [100] | van Loon, G. (2019) Cardiac Arrhythmias in Horses. Veterinary Clinics of North America: Equine Practice, 35, 85-102. https://doi.org/10.1016/j.cveq.2018.12.004 |
| [101] | Patteson, M.W. (1996) Equine Cardiology. Blackwell Science, 254. |
| [102] | Hesselkilde, E.M., Isaksen, J.L., Petersen, B.V., Carstensen, H., Jespersen, T., Pehrson, S., et al. (2020) A Novel Approach for Obtaining 12-Lead Electrocardiograms in Horses. Journal of Veterinary Internal Medicine, 35, 521-531. https://doi.org/10.1111/jvim.15980 |
| [103] | Tilley, L.P. (1985) Essentials of Canine and Feline Electrocardiography. 2nd Edition， Lea and Febiger, 19-54. |
| [104] | Jalife, J. (2003) Rotors and Spiral Waves in Atrial Fibrillation. Journal of Cardiovascular Electrophysiology, 14, 776-780. https://doi.org/10.1046/j.1540-8167.2003.03136.x |
| [105] | Hesselkilde, E.Z., Carstensen, H., Flethøj, M., Fenner, M., Kruse, D.D., Sattler, S.M., et al. (2019) Longitudinal Study of Electrical, Functional and Structural Remodelling in an Equine Model of Atrial Fibrillation. BMC Cardiovascular Disorders, 19, Article No. 228. https://doi.org/10.1186/s12872-019-1210-4 |
| [106] | Schwarzwald, C.C., Schober, K.E. and Bonagura, J.D. (2007) Echocardiographic Evidence of Left Atrial Mechanical Dysfunction after Conversion of Atrial Fibrillation to Sinus Rhythm in 5 Horses. Journal of Veterinary Internal Medicine, 21, 820-827. https://doi.org/10.1111/j.1939-1676.2007.tb03027.x |
| [107] | Lamb, A.P., Meurs, K.M. and Hamlin, R.L. (2010) Correlation of Heart Rate to Body Weight in Apparently Normal Dogs. Journal of Veterinary Cardiology, 12, 107-110. https://doi.org/10.1016/j.jvc.2010.04.001 |
| [108] | Katayama, K., Kaur, J., Young, B.E., Barbosa, T.C., Ogoh, S. and Fadel, P.J. (2018) High-intensity Muscle Metaboreflex Activation Attenuates Cardiopulmonary Baroreflex-Mediated Inhibition of Muscle Sympathetic Nerve Activity. Journal of Applied Physiology, 125, 812-819. https://doi.org/10.1152/japplphysiol.00161.2018 |
| [109] | Decloedt, A., Schwarzwald, C.C., De Clercq, D., Van Der Vekens, N., Pardon, B., Reef, V.B., et al. (2015) Risk Factors for Recurrence of Atrial Fibrillation in Horses after Cardioversion to Sinus Rhythm. Journal of Veterinary Internal Medicine, 29, 946-953. https://doi.org/10.1111/jvim.12606 |
| [110] | Kirchhof, P., Lip, G.Y.H., van Gelder, I.C., Bax, J., Hylek, E., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Ezekowitz, M., et al. (2011) Comprehensive Risk Reduction in Patients with Atrial Fibrillation: Emerging Diagnostic and Therapeutic Options. Thrombosis and Haemostasis, 106, 1012-1019. |
| [111] | Linz, D., Hesselkilde, E., Kutieleh, R., Jespersen, T., Buhl, R. and Sanders, P. (2020) Pulmonary Vein Firing Initiating Atrial Fibrillation in the Horse: Oversized Dimensions but Similar Mechanisms. Journal of Cardiovascular Electrophysiology, 31, 1211-1212. https://doi.org/10.1111/jce.14422 |
| [112] | Ausma, J., Wijffels, M., Thoné, F., Wouters, L., Allessie, M. and Borgers, M. (1997) Structural Changes of Atrial Myocardium Due to Sustained Atrial Fibrillation in the Goat. Circulation, 96, 3157-3163. https://doi.org/10.1161/01.cir.96.9.3157 |
| [113] | van Loon, G. (2001) Effect of Experimental Chronic Atrial Fibrillation in Equines. In: van Loon, G., Ed., Atrial Pacing and Experimental Atrial Fibrillation in Equines, Ghent University. Faculty of Veterinary Medicine, 161-206. http://hdl.handle.net/1854/LU-522170 |
| [114] | Umana, E., Solares, C.A. and Alpert, M.A. (2003) Tachycardia-Induced Cardiomyopathy. The American Journal of Medicine, 114, 51-55. https://doi.org/10.1016/s0002-9343(02)01472-9 |
| [115] | Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J.J., Blomström-Lundqvist, C., et al. (2020) 2020 ESC Guidelines for the Diagnosis and Management of Atrial Fibrillation Developed in Collaboration with the European Association for Cardio-Thoracic Surgery (EACTs). European Heart Journal, 42, 373-498. https://doi.org/10.1093/eurheartj/ehaa612 |
| [116] | Stoddard, M.F. (2000) Risk of Thromboembolism in Acute Atrial Fibrillation or Atrial Flutter. Echocardiography, 17, 393-405. https://doi.org/10.1111/j.1540-8175.2000.tb01155.x |
| [117] | de Solís, C.N., Reef, V.B., Slack, J. and Jose-Cunilleras, E. (2016) Evaluation of Coagulation and Fibrinolysis in Horses with Atrial Fibrillation. Journal of the American Veterinary Medical Association, 248, 201-206. https://doi.org/10.2460/javma.248.2.201 |
| [118] | Negreva, M., Prodanova, K., Vitlianova, K. and Madjova, C. (2020) Paroxysmal Atrial Fibrillation: Changes in Factor VIII and Von Willebrand Factor Impose Early Hypercoagulability. Archives of Medical Science—Atherosclerotic Diseases, 5, 140-147. https://doi.org/10.5114/amsad.2020.97101 |
| [119] | Miller, C.W., O’Grady, M.R., Holmberg, D.L. and Cockshutt, J.R. (1989) Canine Congenital Aortic Stenosis: A Review of the Literature and Commentary. The Canadian Veterinary Journal, 30, 811-815. |
| [120] | Lip, G.Y.H. (2001) Paroxysmal Atrial Fibrillation. QJM, 94, 665-678. https://doi.org/10.1093/qjmed/94.12.665 |
| [121] | Lyle, C.H., Blissitt, K.J., Kennedy, R.N., Mc Gorum, B.C., Newton, J.R., Parkin, T.D.H., et al. (2011) Risk Factors for Race-Associated Sudden Death in Thoroughbred Racehorses in the UK (2000-2007). Equine Veterinary Journal, 44, 459-465. https://doi.org/10.1111/j.2042-3306.2011.00496.x |
| [122] | Lotstra, R.J., van den Broek, J., Power, T., Marr, C.M. and Wijnberg, I.D. (2015) Retrospective Observational Study on the Outcome of Medical Treatment of Atrial Fibrillation. Equine Veterinary Journal, 47, 28-28. https://doi.org/10.1111/evj.12486_63 |
| [123] | Hiraga, A. and Kubo, K. (1999) Two Cases of Paroxysmal Atrial Fibrillation during Exercise in Horses. Equine Veterinary Education, 11, 6-10. https://doi.org/10.1111/j.2042-3292.1999.tb00909.x |
| [124] | Blissitt, K.J. (1999) Diagnosis and Treatment of Atrial Fibrillation. Equine Veterinary Education, 11, 11-19. https://doi.org/10.1111/j.2042-3292.1999.tb00910.x |
| [125] | Gordon, S.G., Saunders, A.B. and Malcolm, E. (2023) Antiarrhythmics for Use in Animals. MSD Veterinary Manual. |
| [126] | Schotten, U., Verheule, S., Kirchhof, P. and Goette, A. (2011) Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal. Physiological Reviews, 91, 265-325. https://doi.org/10.1152/physrev.00031.2009 |
| [127] | Wall, M., Calvert, C.A., Sanderson, S.L., Leonhardt, A., Barker, C. and Fallaw, T.K. (2005) Evaluation of Extended-Release Diltiazem Once Daily for Cats with Hypertrophic Cardiomyopathy. Journal of the American Animal Hospital Association, 41, 98-103. https://doi.org/10.5326/0410098 |
| [128] | Birettoni, F., Porciello, F., Rishniw, M., della Rocca, G., Di Salvo, A. and Sgorbini, M. (2007) Treatment of Chronic Atrial Fibrillation in the Horse with Flecainide: Personal Observation. Veterinary Research Communications, 31, 273-275. https://doi.org/10.1007/s11259-007-0045-0 |
| [129] | Gerber, H., Chuit, P. and Schatzmann, H.J. (1971) Treatment of Atrial Fibrillation in the Horse with Intravenous Dihydroquinidine Gluconate. Equine Veterinary Journal, 3, 110-113. https://doi.org/10.1111/j.2042-3306.1971.tb04450.x |
| [130] | Keen, P. (1990) The Use of Drugs in the Treatment of Cardiac Disease in the Horse. Equine Veterinary Education, 2, 81-82. https://doi.org/10.1111/j.2042-3292.1990.tb01394.x |
| [131] | Lekeux, P., Muylle, E., Henroteaux, M. and Bienfet, V. (1981) Comparison of Different Treatments of Atrial Fibrillation in the Horse. Zentralblatt für Veterinärmedizin Reihe A, 28, 475-480. https://doi.org/10.1111/j.1439-0442.1981.tb01215.x |
| [132] | Meurs, K.M., Spier, A.W., Wright, N.A., Atkins, C.E., DeFrancesco, T.C., Gordon, S.G., et al. (2002) Comparison of the Effects of Four Antiarrhythmic Treatments for Familial Ventricular Arrhythmias in Boxers. Journal of the American Veterinary Medical Association, 221, 522-527. https://doi.org/10.2460/javma.2002.221.522 |
| [133] | van Loon, G. (2003) Methods of Treatment and New Management Techniques in Horses with Atrial Fibrillation. The Autumn Meeting of the Veterinary Cardiovascular Society, 5-6 December 2003, Loughborough, 12-17. http://hdl.handle.net/1854/LU-375140 |
| [134] | Lei, M., Wu, L., Terrar, D.A. and Huang, C.L. (2018) Modernized Classification of Cardiac Antiarrhythmic Drugs. Circulation, 138, 1879-1896. https://doi.org/10.1161/circulationaha.118.035455 |
| [135] | Muir, W.W. and McGuirk, S.M. (1985) Pharmacology and Pharmacokinetics of Drugs Used to Treat Cardiac Disease in Horses. Veterinary Clinics of North America: Equine Practice, 1, 335-352. https://doi.org/10.1016/s0749-0739(17)30759-9 |
| [136] | Amada, A. and Kurita, H. (1978) Treatment of Atrial Fibrillation with Quinidine Sulfate in the Racehorse. Bulletin of Equine Research Institute, 1978, 47-61. |
| [137] | Bertone, J.J. and Wingfield, W.E. (1987) Atrial Fibrillation in Horses. Compendium: Continuing Education for Veterinarians, 9, 763-771. |
| [138] | Deegen, E. and Buntenkotter, S. (1976) Intravenous Infusion of Quinidine Sulfate for Therapy of Equine Auricular Fibrillation. Preliminary Report. Deutsche tierärztliche Wochenschrift, 81, 161-162. |
| [139] | Fenton, F.H., Cherry, E.M. and Kornreich, B.G. (2008) Termination of Equine Atrial Fibrillation by Quinidine: An Optical Mapping Study. Journal of Veterinary Cardiology, 10, 87-103. https://doi.org/10.1016/j.jvc.2008.10.002 |
| [140] | Glendinning, S. (1965) The Use of Quinidine Sulphate for the Treatment of Atrial Fibrillation in Twelve Horses. Veterinary Record, 77, 951-960. https://doi.org/10.1136/vr.77.33.951 |
| [141] | Rosen, M.R. (1995) Consequences of the Sicilian Gambit. European Heart Journal, 16, 32-36. https://doi.org/10.1093/eurheartj/16.suppl_g.32 |
| [142] | Allessie, M.A., Wijffels, M.C. and Dorland, R. (1998) Mechanisms of Pharmacologic Cardioversion of Atrial Fibrillation by Class I Drugs. Journal of Cardiovascular Electrophysiology, 9, S69-S77. |
| [143] | McGuirk, S.M., Muir, W.W. and Sams, R.A. (1981) Pharmacokinetic Analysis of Intravenously and Orally Administered Quinidine in Horses. American Journal of Veterinary Research, 42, 938-942. |
| [144] | Muir, W.W. and McGuirk, S.M. (1984) Hemodynamics before and after Conversion of Atrial Fibrillation to Normal Sinus Rhythm in Horses. Journal of the American Veterinary Medical Association, 184, 965-970. |
| [145] | Reef, V.B. (1999) Tachyarrhythmias—Atrial Fibrillation. In: Marr, C.M., Ed, Cardiology of the Horse, WB Saunders, 186-197. |
| [146] | Fregin, G.F. (1982) The Cardiovascular System. In: Mansmann, R.A., McAllister, E.S. and Pratt, P.W., Eds., Equine Medicine and Surgery, vol. 1 (3rd Edition), American Veterinary Publishing, 645-704. |
| [147] | Patterson, M.W. (1996) Cardiac Arrhythmias, Equine Cardiology. Blackwell Science, 172-205. |
| [148] | Takahashi, Y., Ishikawa, Y. and Ohmura, H. (2018) Treatment of Recent-Onset Atrial Fibrillation with Quinidine and Flecainide in Thoroughbred Racehorses: 107 Cases (1987-2014). Journal of the American Veterinary Medical Association, 252, 1409-1414. https://doi.org/10.2460/javma.252.11.1409 |
| [149] | Ellis, E.J., Ravis, W.R., Malloy, M., Duran, S.H. and Smyth, B.G. (1994) The Pharmacokinetics and Pharmacodynamics of Procainamide in Horses after Intravenous Administration. Journal of Veterinary Pharmacology and Therapeutics, 17, 265-270. https://doi.org/10.1111/j.1365-2885.1994.tb00243.x |
| [150] | Moïse, N.S., Pariaut, R., Gelzer, A.R.M., Kraus, M.S. and Jung, S.W. (2005) Cardioversion with Lidocaine of Vagally Associated Atrial Fibrillation in Two Dogs. Journal of Veterinary Cardiology, 7, 143-148. https://doi.org/10.1016/j.jvc.2005.09.004 |
| [151] | Wright, K.N., Nguyenba, T. and Irvin, H.M. (2019) Lidocaine for Chemical Cardioversion of Orthodromic Atrioventricular Reciprocating Tachycardia in Dogs. Journal of Veterinary Internal Medicine, 33, 1585-1592. https://doi.org/10.1111/jvim.15546 |
| [152] | Pariaut, R., Moïse, N.S., Koetje, B.D., Flanders, J.A., Hemsley, S.A., Farver, T.B., et al. (2008) Lidocaine Converts Acute Vagally Associated Atrial Fibrillation to Sinus Rhythm in German Shepherd Dogs with Inherited Arrhythmias. Journal of Veterinary Internal Medicine, 22, 1274-1282. https://doi.org/10.1111/j.1939-1676.2008.0188.x |
| [153] | Gelzer, A.R.M., Kraus, M.S., Rishniw, M., Hemsley, S.A. and Moïse, N.S. (2010) Combination Therapy with Mexiletine and Sotalol Suppresses Inherited Ventricular Arrhythmias in German Shepherd Dogs Better than Mexiletine or Sotalol Monotherapy: A Randomized Cross-Over Study. Journal of Veterinary Cardiology, 12, 93-106. https://doi.org/10.1016/j.jvc.2010.06.001 |
| [154] | van Loon, G., Blissitt, K.J., Keen, J.A. and Young, L.E. (2004) Use of Intravenous Flecainide in Horses with Naturally-Occurring Atrial Fibrillation. Equine Veterinary Journal, 36, 609-614. https://doi.org/10.2746/0425164044864516 |
| [155] | Ohmura, H., Hiraga, A., Aida, H., Takahashi, T. and Nukada, T. (2001) Determination of Oral Dosage and Pharmacokinetic Analysis of Flecainide in Horses. Journal of Veterinary Medical Science, 63, 511-514. https://doi.org/10.1292/jvms.63.511 |
| [156] | Haugaard, M.M., Pehrson, S., Carstensen, H., Flethøj, M., Hesselkilde, E.Z., Præstegaard, K.F., et al. (2014) Antiarrhythmic and Electrophysiologic Effects of Flecainide on Acutely Induced Atrial Fibrillation in Healthy Horses. Journal of Veterinary Internal Medicine, 29, 339-347. https://doi.org/10.1111/jvim.12496 |
| [157] | Risberg, Å.I. and McGuirk, S.M. (2006) Successful Conversion of Equine Atrial Fibrillation Using Oral Flecainide. Journal of Veterinary Internal Medicine, 20, 207-209. https://doi.org/10.1111/j.1939-1676.2006.tb02844.x |
| [158] | Robinson, S.J. and Feary, D.J. (2008) Sudden Death Following Oral Administration of Flecainide to Horses with Naturally Occurring Atrial Fibrillation. Australian Equine Veterinarian, 27, 49-51. https://www.ava.com.au/contentassets/997742f721614ea7a29df405118d51a9/sudden_death_following_oral.pdf |
| [159] | De Clercq, D., van Loon, G., Tavernier, R., Verbesselt, R. and Deprez, P. (2009) Use of Propafenone for Conversion of Chronic Atrial Fibrillation in Horses. American Journal of Veterinary Research, 70, 223-227. https://doi.org/10.2460/ajvr.70.2.223 |
| [160] | Puigdemont, A., Riu, J.L., Guitart, R. and Arboix, M. (1990) Propafenone Kinetics in the Horse. Comparative Analysis of Compartmental and Noncompartmental Models. Journal of Pharmacological Methods, 23, 79-85. https://doi.org/10.1016/0160-5402(90)90035-j |
| [161] | Marr, C.M. and Reimer, J.M. (1995) The Cardiovascular System. In: Higgins, A.J. and Wright, I.M., Eds., The Equine Manual, WB Saunders, 381-408. |
| [162] | Romito, G. and Guglielmini, C. (2024) Fibrillazione atriale canina: Un vecchio nemico, nuove evidenze. Veterinaria, No. 1, 5-15. |
| [163] | Verschoor-Kirss, M., Rozanski, E. and Rush, J.E. (2021) Use of Esmolol for Control of Tachycardia in 28 Dogs and Cats (2003-2020). Journal of Veterinary Emergency and Critical Care, 32, 243-248. https://doi.org/10.1111/vec.13162 |
| [164] | Pariaut, R., Santilli, R.A. and Moise, N.S. (2014) Supraventricular Tachyarrhythmias in Dogs. Kirk’s Current Veterinary Therapy, XV, 737-744. |
| [165] | De Clercq, D., van Loon, G., Baert, K., Tavernier, R., Croubels, S., De Backer, P., et al. (2006) Intravenous Amiodarone Treatment in Horses with Chronic Atrial Fibrillation. The Veterinary Journal, 172, 129-134. https://doi.org/10.1016/j.tvjl.2005.04.001 |
| [166] | de Clercq, D., van Loon, G., Baert, K., Tavernier, R., Croubels, S., de Backer, P., et al. (2007) Effects of an Adapted Intravenous Amiodarone Treatment Protocol in Horses with Atrial Fibrillation. Equine Veterinary Journal, 39, 344-349. https://doi.org/10.2746/042516407x182811 |
| [167] | Imhasly, A., Tschudi, P.R. and Gerber, V. (2008) Combined Amiodarone and Chinidin Sulfate Show No Advantage over Chinidin Sulfate Alone in Equine Atrial Fibrillation. Pferdeheilkunde Equine Medicine, 24, 693-698. https://doi.org/10.21836/pem20080506 |
| [168] | Levy, N.A., Koenigshof, A.M. and Sanders, R.A. (2016) Retrospective Evaluation of Intravenous Premixed Amiodarone Use and Adverse Effects in Dogs (17 Cases: 2011-2014). Journal of Veterinary Cardiology, 18, 10-14. https://doi.org/10.1016/j.jvc.2015.10.009 |
| [169] | Pedro, B., López-Alvarez, J., Fonfara, S., Stephenson, H. and Dukes-McEwan, J. (2011) Retrospective Evaluation of the Use of Amiodarone in Dogs with Arrhythmias (from 2003 to 2010). Journal of Small Animal Practice, 53, 19-26. https://doi.org/10.1111/j.1748-5827.2011.01142.x |
| [170] | Romito, G., Gemma, N., Dondi, F., Mazzoldi, C., Fasoli, S. and Cipone, M. (2024) Efficacy and Safety of Antiarrhythmic Therapy in Dogs with Naturally Acquired Tachyarrhythmias Treated with Amiodarone or Sotalol: A Retrospective Analysis of 64 Cases. Journal of Veterinary Cardiology, 53, 20-35. https://doi.org/10.1016/j.jvc.2024.03.002 |
| [171] | Saunders, A.B., Miller, M.W., Gordon, S.G. and Wiele, C.M.V.D. (2006) Oral Amiodarone Therapy in Dogs with Atrial Fibrillation. Journal of Veterinary Internal Medicine, 20, 921-926. https://doi.org/10.1111/j.1939-1676.2006.tb01806.x |
| [172] | Broux, B., De Clercq, D., Decloedt, A., Vera, L., Devreese, M., Gehring, R., et al. (2017) Pharmacokinetics and Electrophysiological Effects of Sotalol Hydrochloride in Horses. Equine Veterinary Journal, 50, 377-383. https://doi.org/10.1111/evj.12765 |
| [173] | Decloedt, A., Broux, B., De Clercq, D., Deprez, P., Van Steenkiste, G., Vera, L., et al. (2018) Effect of Sotalol on Heart Rate, QT Interval, and Atrial Fibrillation Cycle Length in Horses with Atrial Fibrillation. Journal of Veterinary Internal Medicine, 32, 815-821. https://doi.org/10.1111/jvim.15055 |
| [174] | Saengklub, N., Limprasutr, V., Sawangkoon, S., Hamlin, R.L. and Kijtawornrat, A. (2017) Dronedarone Attenuates the Duration of Atrial Fibrillation in a Dog Model of Sustained Atrial Fibrillation. Experimental Animals, 66, 251-258. https://doi.org/10.1538/expanim.17-0002 |
| [175] | Pariaut, R. (2017) Atrial Fibrillation. Veterinary Clinics of North America: Small Animal Practice, 47, 977-988. https://doi.org/10.1016/j.cvsm.2017.04.002 |
| [176] | Schwarzwald, C.C., Bonagura, J.D. and Luis-Fuentes, V. (2005) Effects of Diltiazem on Hemodynamic Variables and Ventricular Function in Healthy Horses. Journal of Veterinary Internal Medicine, 19, 703-711. https://doi.org/10.1111/j.1939-1676.2005.tb02749.x |
| [177] | Schwarzwald, C.C., Hamlin, R.L., Bonagura, J.D., Nishijima, Y., Meadows, C. and Carnes, C.A. (2007) Atrial, SA Nodal, and AV Nodal Electrophysiology in Standing Horses: Normal Findings and Electrophysiologic Effects of Quinidine and Diltiazem. Journal of Veterinary Internal Medicine, 21, 166-175. https://doi.org/10.1111/j.1939-1676.2007.tb02943.x |
| [178] | Miyamoto, M., Nishijima, Y., Nakayama, T. and Hamlin, R.L. (2000) Cardiovascular Effects of Intravenous Diltiazem in Dogs with Iatrogenic Atrial Fibrillation. Journal of Veterinary Internal Medicine, 14, 445. https://doi.org/10.1892/0891-6640(2000)014<0445:ceoidi>2.3.co;2 |
| [179] | Gelzer, A.R.M., Kraus, M.S., Rishniw, M., Moïse, N.S., Pariaut, R., Jesty, S.A., et al. (2009) Combination Therapy with Digoxin and Diltiazem Controls Ventricular Rate in Chronic Atrial Fibrillation in Dogs Better than Digoxin or Diltiazem Monotherapy: A Randomized Crossover Study in 18 Dogs. Journal of Veterinary Internal Medicine, 23, 499-508. https://doi.org/10.1111/j.1939-1676.2009.0301.x |
| [180] | Allerton, F. (2020) BSAVA Small Animal Formulary 10th Edition: Part A—Canine and Feline. British Small Animal Veterinary. |
| [181] | Buhl, R., Meldgaard, C. and Barbesgaard, L. (2010) Cardiac Arrhythmias in Clinically Healthy Showjumping Horses. Equine Veterinary Journal, 42, 196-201. https://doi.org/10.1111/j.2042-3306.2010.00185.x |
| [182] | Kittleson, M., Keene, B., Pion, P. and Woodfield, J. (1988) Verapamil Administration for Acute Termination of Supraventricular Tachycardia in Dogs. Journal of the American Veterinary Medical Association, 193, 1525-1529. |
| [183] | Parraga, M.E., Kittleson, M.D. and Drake, C.M. (1995) Quinidine Administration Increases Steady State Serum Digoxin Concentration in Horses. Equine Veterinary Journal, 27, 114-119. https://doi.org/10.1111/j.2042-3306.1995.tb04998.x |
| [184] | Riesen, S.C., Schober, K.E., Smith, D.N., Otoni, C.C., Li, X. and Bonagura, J.D. (2012) Effects of Ivabradine on Heart Rate and Left Ventricular Function in Healthy Cats and Cats with Hypertrophic Cardiomyopathy. American Journal of Veterinary Research, 73, 202-212. https://doi.org/10.2460/ajvr.73.2.202 |
| [185] | Tang, B. (2015) Effects of Ivabradine on Cardiac Electrophysiology in Dogs with Age-Related Atrial Fibrillation. Medical Science Monitor, 21, 1414-1420. https://doi.org/10.12659/msm.894320 |
