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从遗传学角度来看肠道菌群对青光眼的因果效应：一项孟德尔随机化研究
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Abstract:
目的：探讨肠道菌群(GM)对青光眼、原发性开角型青光眼(POAG)和原发性闭角型青光眼(PACG)的因果关系。方法：采用孟德尔随机化分析方法，利用GM相关GWAS数据(18,340例)、青光眼相关GWAS数据(18,902例及358,375对照)、POAG相关GWAS数据(7756例及358,375对照)和PACG相关GWAS数据(1199例及358,375对照)确定GM对青光眼的因果效应。结果以比值比(OR)和95%置信区间(CI)表示。结果：MR分析结果显示，genus LachnospiraceaeUCG010 (IVW, OR = 1.20, 95% CI [1.06, 1.35], P = 0.0029)、genus Ruminiclostridium9 (IVW, OR = 1.26, 95% CI [1.08, 1.46], P = 0.0026)和genus Streptococcus (IVW, OR = 1.17, 95% CI [1.05, 1.30], P = 0.0053)与青光眼风险显著增加有因果关系，而family Oxalobacteraceae (IVW, OR = 0.88, 95% CI [0.80, 0.97], P = 0.0077)与青光眼风险显著降低有因果关系。phylum Actinobacteria与POAG风险显著增加有因果关系。Class Erysipelotrichia、order Erysipelotrichales、family Erysipelotrichaceae、genus Anaerotruncus与PACG风险显着增加有因果关系。结论：我们的研究从不同分类水平的GM进一步证实了GM对青光眼的因果效应，以及GM对POAG和PACG的相对特异性。然而，需要进一步的研究来证实这些结论。
Purpose: To verify the causal effects of gut microbiota (GM) on glaucoma, primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Methods: Mendelian randomization analysis was conducted to identify the causal effect of GM on glaucoma via using GM-related GWAS data (18,340 samples), glaucoma-related GWAS data (18,902 cases and 358,375 controls), POAG-related GWAS data (7756 cases and 358,375 controls) and PACG-related GWAS data (1199 cases and 358,375 controls). The outcome was expressed as odds ratio (OR) with 95% confidence intervals (CI). Results: The MR analysis results presented that genus LachnospiraceaeUCG010 (IVW, OR = 1.20, 95% CI [1.06, 1.35], P = 0.0029), genus Ruminiclostridium9 (IVW, OR = 1.26, 95% CI [1.08, 1.46], P = 0.0026) and genus Streptococcus (IVW, OR = 1.17, 95% CI [1.05, 1.30], P = 0.0053) were causally associated with a significantly increased risk of glaucoma, while family Oxalobacteraceae (IVW, OR = 0.88, 95% CI [0.80, 0.97], P = 0.0077) were causally associated with a significantly decreased risk of glaucoma. Phylum Actinobacteria was causally associated with a significantly increased risk of POAG. Class Erysipelotrichia, order Erysipelotrichales, family Veillonellaceae and genus Anaerotruncus were causally associated with a significantly increased risk of PACG. Conclusions: Our research further confirmed the causal effect of GM on glaucoma from diverse taxonomies and the relative specificity of GM on POAG and PACG. However, further research is needed to confirm these conclusions.
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