Evaluation of the Pharmacological Potential of Strychnoscamptoneura Trunk Bark Hydroethanol Extract on Reproductive Functions in Male Guinea Pigs (Cavia porcellus) Exposed to Cypermethrin
The main objective of this study was to evaluate the pharmacological potential of the hydroethanol extract of Strychnoscamptoneura trunk bark on reproductive functions in male guinea pigs exposed to cypermethrin. The results showed that administration of the hydroethanolic extract (100 and 250 mg/kg) of Strychnoscamptoneura trunk bark after exposure of the animals to cypermethrin induced a highly significant (p < 0.01) increase at 100 mg/kg and a highly significant (p < 0.001) increase in sperm concentration per epididymal tail at 250 mg/kg compared with cypermethrin-treated animals. Furthermore, administration of the hydroethanol extract of Strychnoscamptoneura trunk bark produced a highly significant (p < 0.001) dose-dependent increase in motile and vital sperm levels, in contrast to positive controls exposed to cypermethrin with a highly significant (p < 0.001) decrease in motile and vital sperm levels; a highly significant decrease (p < 0.001) in the rate of dead sperm compared with cypermethrin-treated male guinea pigs. There was also a highly significant (p < 0.01) decrease in reaction time at 250 mg/kg, and a highly significant (p < 0.001) dose-dependent increase in serum testosterone levels in male guinea pigs exposed to cypermethrin, compared with animals treated with distilled water and those exposed to cypermethrin. These results suggest that the hydroethanol extract of Strychnoscamptoneura trunk bark may have protective effects against cypermethrin-induced male infertility due to its androgenic, spermatogenic and antiradical properties.
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