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生殖道性传播病原体感染对于阴道微生态及HPV感染的相关讨论
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Abstract:
阴道微生态，作为构成人体五大微生态系统的重要部分，其内部菌群多样且分型复杂，构成了女性生殖道健康的一道关键防御机制，同时也是女性阴道不可或缺的屏障之一。这一微生态系统由阴道独特的解剖结构、丰富的阴道菌群、女性内分泌调节系统以及阴道局部的免疫系统共同构建而成。多种因素在这个微环境中相互作用、相互影响，共同维系着阴道微生态系统的动态平衡状态。人乳头瘤病毒(human papilloma virus)的主要传播途径为性行为传播。近年来一些研究表明，某些性传播感染(sexually transmitted infection, STI)病原体可能通过破坏子宫颈黏膜完整性、增强HPV病毒复制等机制在高危型HPV持续感染诱发癌前病变及子宫颈癌的过程中起重要作用。
Vaginal microecology, as an important part of the five microecosystems of the human body, is diverse and complex in its internal flora, which constitutes a key defense mechanism of female reproductive tract health, and is also one of the indispensable barriers of female vagina. This microecosystem is built by the unique anatomy of the vagina, the rich vaginal flora, the female endocrine regulatory system, and the local immune system of the vagina. A variety of factors interact and influence each other in this microenvironment, and jointly maintain the dynamic balance of the vaginal microecosystem. The main transmission route of the human papilloma virus is sexual transmission. In recent years, some studies have shown that certain sexually transmitted infection (STI) pathogens may be able to induce precancerous lesions by destroying the integrity of the cervical mucosa and enhancing the replication of the HPV virus in high-risk HPV types. Persistent infection may play an important role in the development of precancerous lesions and cervical cancer.
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