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白藜芦醇对乳腺癌分子机制的研究进展
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Abstract:
白藜芦醇(Resveratrol)是一种天然存在于葡萄、浆果和花生中的多酚化合物，因其显著的抗氧化、抗炎和抗癌特性，近年来在乳腺癌研究中备受关注。文章综述了白藜芦醇在乳腺癌细胞中的分子机制及其在抗肿瘤过程中的作用。白藜芦醇通过靶向多种信号分子，抑制乳腺癌细胞的增殖，诱导细胞凋亡和自噬，抑制细胞迁移和侵袭，并重组细胞代谢。此外，白藜芦醇与化疗和放疗药物具有协同作用的潜力。尽管临床前研究结果令人鼓舞，但白藜芦醇的生物利用度和稳定性问题仍需解决。未来的研究应聚焦于优化白藜芦醇的递送系统，深入揭示其分子作用机制，并评估其长期使用的安全性和有效性，为乳腺癌患者提供更有效的治疗选择。
Resveratrol, a polyphenolic compound naturally found in grapes, berries, and peanuts, has attracted significant attention in recent years due to its potent antioxidant, anti-inflammatory, and anti-cancer properties. This review summarizes the molecular mechanisms of resveratrol in breast cancer cells and its role in tumor suppression. Resveratrol exerts its effects by targeting multiple signaling molecules, thereby inhibiting the proliferation of breast cancer cells, inducing apoptosis and autophagy, suppressing cell migration and invasion, and reprogramming cellular metabolism. Additionally, resveratrol shows potential synergistic effects when combined with chemotherapeutic and radiotherapeutic agents. Despite promising preclinical results, issues related to the bioavailability and stability of resveratrol remain to be addressed. Future research should focus on optimizing resveratrol delivery systems, deeply elucidating its molecular mechanisms, and evaluating the safety and efficacy of long-term use, with the ultimate goal of providing more effective treatment options for breast cancer patients.
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