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更年期女性共病糖尿病患者围绝经期症状特征及其对生活质量的影响
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Abstract:
目的:探讨分析更年期女性共病糖尿病患者围绝经期症状现状及其生活质量,并分析其围绝经期症状特征。方法:本研究采用方便随机抽样法选取于2023年8月至2024年10月在吴起县人民医院妇产科、内科住院部或门诊部就诊的更年期女性共病糖尿病患者作为调查对象,选用一般资料调查表、改良Kupperman评分量表、围绝经期生存质量量表(MENQOL)进行调查。本研究一般资料中计数资料用频数与构成比((n) %)来描述,计量资料符合正态分布采用(
)描述;组间比较采用t检验或方差分析,t检验或方差分析更年期女性共病糖尿病患者围绝经期相关症状在一般资料和疾病相关资料上的差异及影响因素,更年期女性共病糖尿病患者生命质量影响因素采用多元线性回归分析,以P < 0.05有统计学差异。结果:共纳入137例更年期女性共病糖尿病患者,年龄在42~64周岁,平均年龄(52.01 ± 5.50)岁,平均糖尿病病程在1~20年,为(6.01 ± 4.55)年。本研究结果显示,更年期女性共病糖尿病患者围绝经期生存质量量表总得分为(71.24 ± 12.41)分,围绝经期综合征症状最低分为15分,最高分为58分,总得分为(29.24 ± 12.41)分,其中存在轻度围绝经期综合征的患者48例,占比35.0%,占比最高,围绝经期综合征得分在35分以上的患者44例,占到32.1%。本研究单因素分析调查显示,55~64岁、糖尿病病程是更年期共病糖尿病患者其围绝经期综合征症状严重程度的影响因素,糖尿病病程进入多元线性回归方程(P < 0.05)。患者围绝经期综合征症状中,疲乏是最常见的,其次是失眠、易激动、抑郁及疑心、眩晕、骨关节痛并列出现,但在围绝经期综合征症状中泌尿系统感染、失眠、性生活状况症状在重度的患者占比较大,分别占到其症状的33.8%、30.9%、21.2%。结论:本研究更年期女性共病糖尿病患者围绝经期综合征症状较为严重,生存质量较低。围绝经期综合征的频率、严重程度随着年龄的增长而增加,更年期女性共病糖尿病患者随着病程的增加其围绝经期综合征的严重程度也增加。疲乏是该群体最常见的症状,其次是失眠、易激动、抑郁及疑心、眩晕、骨关节痛并列出现,但在围绝经期综合征症状中泌尿系统感染、失眠、性生活状况症状在重度的患者占比较大,可能与糖尿病自主神经功能紊乱有关,二者症状叠加是影响该群体生命质量的主要因素。
Objective: To investigate the status quo and quality of life of perimenopausal female patients with comorbidity diabetes, and to analyze the characteristics of perimenopausal symptoms. Method: In this study, convenient random sampling method was used to select menopausal female patients with comorbiditic diabetes who were treated in the obstetrics and gynecology department, internal medicine inpatient department or outpatient department of Wuqi County People’s Hospital from August 2023 to October 2024 as the investigation objects, and general data questionnaire, modified Kupperman score scale and Perimenopausal Quality of Life scale (MENQOL) were used Investigate. In the general data of this study, the counting data were described by frequency and component ratio ((n) %), and the measurement data conforming to normal distribution were described by (
). T test or analysis of variance were used for comparison between groups. T test or analysis
[1] | 张凡, 张广美. 女性绝经综合征的研究进展[J]. 中国临床研究, 2017, 30(8): 1131-1133, 1137. |
[2] | Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B.B., et al. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Research and Clinical Practice, 183, Article ID: 109119. https://doi.org/10.1016/j.diabres.2021.109119 |
[3] | 贾钰, 周紫彤, 曹学华, 等. 中国40~65岁女性围绝经期综合征发生率的Meta分析[J]. 中国全科医学, 2023, 26(32): 4080-4088. |
[4] | 国家老年医学中心, 中华医学会老年医学分会, 中国老年保健协会糖尿病专业委员会, 等. 中国老年糖尿病诊疗指南(2024版) [J]. 协和医学杂志, 2024, 15(4): 771-800. |
[5] | 中国中西医结合学会妇产科专业委员会. 更年期综合征中西医结合诊治指南(2023年版) [J]. 中国实用妇科与产科杂志, 2023, 39(8): 799-808. |
[6] | 徐杰, 聂宏, 陈着, 等. 围绝经期综合征患者二元应对水平及其影响因素研究[J]. 中国实用护理杂志, 2024, 40(6): 434-440. |
[7] | 李斌, 黄艺舟, 贾瀛娴, 等. 绝经期健康相关生活质量常用量表及其应用的研究进展[J]. 中国全科医学, 2020, 23(34): 4400-4404, 4406. |
[8] | Li, R., Ma, M., Xiao, X., Xu, Y., Chen, X. and Li, B. (2016) Perimenopausal Syndrome and Mood Disorders in Perimenopause. Medicine, 95, e4466. https://doi.org/10.1097/md.0000000000004466 |
[9] | Ghadiri-Anari, A., Gholami, S., Zolfaghari, F. and Namiranian, N. (2019) Prediabetes and Gastrointestinal (GI) Symptoms: A Cross-Sectional Study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, 844-846. https://doi.org/10.1016/j.dsx.2018.12.005 |
[10] | Wegeberg, A., Bertoli, D., Ejskjaer, N., Brock, B., Drewes, A.M. and Brock, C. (2021) Gastrointestinal Function in Diabetes Is Affected Regardless of Asymptomatic Appearance. Journal of Internal Medicine, 291, 505-512. https://doi.org/10.1111/joim.13416 |
[11] | 赵群, 王文绢. 2型糖尿病血管并发症危险因素控制研究进展[J]. 中国慢性病预防与控制, 2022, 30(4): 302-306. |
[12] | 姜静雯, 吴敏. 糖尿病神经病变的诊治进展[J]. 神经损伤与功能重建, 2022, 17(2): 95-96, 102. |
[13] | 陈崇鑫, 余萌, 杨征, 等. 2型糖尿病患者糖化血红蛋白指数与糖尿病心脏自主神经病变的相关性研究[J]. 中华糖尿病杂志, 2021, 13(3): 238-244. |
[14] | Li, S., Yang, D., Zhou, X., Chen, L., Liu, L., Lin, R., et al. (2023) Neurological and Metabolic Related Pathophysiologies and Treatment of Comorbid Diabetes with Depression. CNS Neuroscience & Therapeutics, 30, e14497. https://doi.org/10.1111/cns.14497 |
[15] | Kinjo, M., Masuda, K., Nakamura, Y., Miyakawa, J., Tambo, M. and Fukuhara, H. (2023) Comparison of Mirabegron and Vibegron in Women with Treatment-Naive Overactive Bladder: A Randomized Controlled Study. Urology, 175, 67-73. https://doi.org/10.1016/j.urology.2023.02.003 |
[16] | 任红芳, 姜妙芳, 范飞燕. 围绝经期综合征患者睡眠障碍现状及影响因素研究[J]. 中国妇幼保健, 2023, 38(2): 359-362. |