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中性粒细胞胞外陷阱在重症肺炎发生发展中的作用
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Abstract:
中性粒细胞胞外陷阱(Neutrophil Extracellular Traps, NETs)由中性粒细胞活化后分泌并释放到细胞外，是一种由DNA、组蛋白和抗菌蛋白组成的网状结构，负责捕获和杀死细胞外病原体。中性粒细胞在细菌、真菌、炎症因子等刺激物的刺激下被活化并持续释放NETs，可使周围血小板活化，组织细胞受损。一些研究已经证明了Nets的形成是促进炎症发生发展的方式之一，炎症因子如IL-8、IL-1β和TNF-α与NETs的形成关系密切。近年来，NETs在重症肺炎(Severe Pneumonia, SP)发生发展中的作用不断被揭示出来。因此，我们综述了目前对NETs与重症肺炎相关的作用机制的相关研究。旨在为评估重症肺炎病情的严重程度及寻找治疗重症肺炎的新靶点提供理论依据。
Neutrophil Extracellular Traps (NETs) are secreted and released outside the cell by activated neutrophils and are a meshwork of DNA, histones and antimicrobial proteins responsible for trapping and killing extracellular pathogens. The activation and sustained release of NETs by neutrophils stimulated by stimuli such as bacteria, fungi and inflammatory factors can lead to activation of peripheral platelets and damage to tissue cells. Several studies have demonstrated that the formation of NETs is one of the ways to promote the occurrence and development of inflammation, and inflammatory factors such as IL-8, IL-1β, and TNF-α are closely related to the formation of NETs. In recent years, the role of NETs in the occurrence and development of Severe Pneumonia (SP) has been continuously revealed. Therefore, we reviewed the current studies related to the mechanism of action of NETs associated with severe pneumonia. The aim is to provide a theoretical basis for evaluating the severity of severe pneumonia and searching for new targets for the treatment of severe pneumonia.
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