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冠心病合并抑郁患者脑源性神经营养因子与冠状动脉病变的关联研究
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Abstract:
抑郁症和冠心病(CHD)都是世界范围内非常普遍的疾病，也是导致残疾和疾病负担的主要原因。抑郁症在冠心病的发病过程中起着举足轻重的作用，其合并症导致冠心病患者的死亡率呈上升趋势。抑郁症患者患心血管疾病的风险增加。没有理由忽视它对人类健康的威胁。一种机制可能是“神经营养因子重叠”，意味着相同神经营养因子参与CHD和抑郁症的发病机制。最近研究表明，脑源性神经营养因子(BDNF)是假定的候选体液因子。研究BDNF与冠心病患者伴随抑郁症的关系，可能揭示两者间的深层联系，并促进对两病相互作用的理解，从而帮助识别评估冠心病患者抑郁症状严重性的指标。本文将概述当前关于BDNF在冠心病患者中与抑郁症共存的研究动态。
Depression and coronary heart disease (CHD) are both very common diseases worldwide and are major causes of disability and disease burden. Depression plays a pivotal role in the pathogenesis of coronary heart disease, and its comorbidities lead to an increasing mortality rate in patients with coronary heart disease. Patients with depression have an increased risk of cardiovascular disease. There is no reason to ignore its threat to human health. One mechanism may be “neurotrophic factor overlap”, meaning that the same neurotrophic factors are involved in the pathogenesis of CHD and depression. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is a putative candidate liquid factor. Studying the relationship between BDNF and depression in patients with coronary heart disease may reveal a deep connection between the two and promote an understanding of the interaction between the two diseases, thereby helping to identify indicators for assessing the severity of depressive symptoms in patients with coronary heart disease. This article will outline the current research dynamics on the coexistence of BDNF and depression in patients with coronary heart disease.
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