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超声造影对糖尿病患者颈动脉斑块内新生血管的定量及半定量研究
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Abstract:
目的：应用超声造影技术定量及半定量比较糖尿病患者与非糖尿病患者颈动脉斑块内新生血管。方法：回顾性分析2020年7月~2021年11月淄博市中心医院收治的63例颈动脉斑块患者。根据空腹血糖将其分为糖尿病组和非糖尿病组。所有患者均予以超声检查，采用超声造影技术对颈动脉斑块新生血管进行半定量及定量分析，对比两组之间的差异。结果：糖尿病组与非糖尿病组之间血糖差异有统计学意义(P < 0.05)，吸烟史、性别、年龄、体重指数、收缩压、舒张压、甘油三酯、脂蛋白a差异无统计学意义(P > 0.05)。糖尿病组颈动脉斑块内新生血管增强评分、AUC (P/L)和EI (P/L)高于非糖尿病组(P < 0.05)。两组间斑块长度、斑块厚度、ΔTtopeak差异无统计学意义(P > 0.05)。结论：糖尿病患者的颈动脉斑块含有更多的新生血管，斑块更易损，更易发生心脑血管事件。
Objective: To quantitatively and semi-quantitatively compare new vessels within carotid atherosclerotic plaques between diabetic and non-diabetic patients using contrast-enhanced ultrasound (CEUS) technique. Methods: A retrospective analysis was performed on 63 patients with carotid plaques admitted to Zibo Central Hospital from July 2020 to November 2021. The patients were divided into diabetic and non-diabetic groups based on fasting blood glucose levels. All patients underwent ultrasound examination, and CEUS was used for semi-quantitative and quantitative analysis of new vessels within carotid atherosclerotic plaques, and the differences between the two groups were compared. Results: There was a statistically significant difference in fasting blood glucose levels between the diabetic and non-diabetic groups (P < 0.05), while there were no statistically significant differences in smoking history, gender, age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, and lipoprotein(a) levels (P > 0.05). The diabetic group had higher scores for new vessel enhancement within carotid plaques, AUC (P/L), and EI (P/L) compared to the non-diabetic group (P < 0.05). There were no statistically significant differences in plaque length, plaque thickness, and ΔTtopeak between the two groups (P > 0.05). Conclusion: Carotid atherosclerotic plaques in diabetic patients contain more new vessels, are more vulnerable, and are more prone to cardiovascular and cerebrovascular events.
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