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糖尿病足合并坏死性筋膜炎的研究进展
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Abstract:
坏死性筋膜炎(NF)是一种复杂的感染性疾病，其进展迅速、容易危及生命，预后较差，截肢率和死亡率较高。早期诊断、迅速积极的手术清创、抗生素的应用是治疗的关键。该疾病通常是由于易感患者发生的外部创伤所致，最重要的危险因素是糖尿病。糖尿病足(DF)是糖尿病最严重的慢性并发症之一。然而DNF的早期诊断面临着挑战，DNF的患者常合并神经病变其临床表现不典型，极易误诊造成严重后果。本文从DNF的流行病学、诊断及治疗等方面对该领域最新文献作综述，帮助临床医生早期识别DNF，为提高DNF的治疗提供理论和临床依据。
Necrotizing fasciitis (NF) is a complex infectious disease that progresses rapidly, poses a high risk to life, and has a poor prognosis, with high rates of amputation and mortality. Early diagnosis, prompt surgical debridement, and the use of antibiotics are key to treatment. This disease typically arises from external trauma in susceptible patients, with diabetes being the most significant risk factor. Diabetic foot (DF) is one of the most severe chronic complications of diabetes. Therefore, patients with diabetic foot are prone to developing necrotizing fasciitis, but the early diagnosis of diabetic foot combined with necrotizing fasciitis (DNF) is challenging. DNF patients often present with atypical clinical features due to concurrent neuropathy, leading to misdiagnosis and serious consequences. This article reviews the latest literature on the epidemiology, diagnosis, and treatment of DNF, aiming to help clinicians identify DNF early and provide theoretical and clinical evidence to improve its treatment.
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