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CT引导下的碘125粒子植入治疗不可切除胰腺癌的有效性和安全性综述
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Abstract:
胰腺癌是高度恶性的消化系统肿瘤，早期难以诊断且预后不良。全球胰腺癌五年生存率一直低于5%。尽管有多种治疗方法，但碘125粒子植入因其独特优势而备受关注，故对碘125粒子植入在不可切除胰腺癌中的疗效和安全性展开综述。CT引导下经皮粒子植入具有手术时间短、出血少、恢复快、并发症少且医疗费用低的优势。研究表明，该技术能有效控制肿瘤生长，缓解疼痛，延长寿命。碘125粒子植入可单独或与其他疗法结合使用，但需统一剂量和程序以指导临床实践。
Pancreatic cancer is a highly malignant digestive system tumor that is difficult to diagnose in its early stages and has a poor prognosis. The five-year survival rate for pancreatic cancer worldwide is less than 5%. Despite various treatment options, iodine-125 (I-125) seed implantation has garnered considerable attention due to its unique advantages, so a systematic review of the efficacy and safety of I-125 seed implantation in unresectable pancreatic cancer is conducted. Percutaneous seed implantation under CT or ultrasound guidance has the advantages of short operation time, minimal bleeding, fast recovery, fewer complications, and lower medical costs. Studies have shown that this technology can effectively control tumor growth, alleviate pain, and prolong survival. I-125 seed implantation can be used alone or in combination with other therapies, but a uniform dose and protocol should be followed to guide clinical practice.
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