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帕金森病流涎的中医药治疗进展
Advances in Traditional Chinese Medicine Treatment of Salivation in Parkinson’s Disease

DOI: 10.12677/acm.2024.1492465, PP. 332-337

Keywords: 帕金森病,流涎,中医药治疗
Parkinson’s Disease
, Salivation, TCM Treatment

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Abstract:

流涎是帕金森病常见的消化道症状之一,可出现在帕金森病的整个病程中,同时可能与运动症状及非运动症状的严重程度相关,晚期帕金森病患者常伴有严重的流涎,甚至出现感染、吸入性肺炎等危及生命的严重并发症。目前认为帕金森病流涎可能与唾液分泌过多及唾液清除障碍相关,西医治疗以改善症状为主。中医认为本病主因肝脾肺肾功能失调,水液代谢失常所致,在治疗上具有个体化优势。本文旨在结合帕金森病流涎的病理机制及相关危险因素,对其中医药治疗进行阐述。
Drooling is one of the common gastrointestinal symptoms of Parkinson’s disease, which can appear throughout the course of Parkinson’s disease, and may be related to the severity of motor symptoms and non-motor symptoms. At present, it is believed that salivation in Parkinson’s disease may be related to excessive saliva secretion and saliva clearance disorders, and Western medicine treatment is mainly to improve symptoms. Traditional Chinese medicine believes that this disease is mainly caused by the dysfunction of the liver, spleen, lungs and kidneys, and the abnormal metabolism of water and fluid, and has an individualized advantage in treatment. The purpose of this article is to elaborate on the pathological mechanism and related risk factors of salivation in Parkinson’s disease and its traditional Chinese medicine treatment.

References

[1]  Moustafa, S.A., Mohamed, S., Dawood, A., Azar, J., Elmorsy, E., Rizk, N.A.M., et al. (2021) Gut Brain Axis: An Insight into Microbiota Role in Parkinson’s Disease. Metabolic Brain Disease, 36, 1545-1557.
https://doi.org/10.1007/s11011-021-00808-2
[2]  Bergmans, B., Clark, V., Isaacson, S.H. and Bäumer, T. (2023) Recommendations for a Paradigm Shift in Approach to Increase the Recognition and Treatment of Sialorrhea in Parkinson’s Disease. Clinical Parkinsonism & Related Disorders, 9, Article ID: 100223.
https://doi.org/10.1016/j.prdoa.2023.100223
[3]  Qin, X., Li, X., Xin, Z. and Li, Z. (2019) Gastrointestinal Dysfunction in Chinese Patients with Parkinson’s Disease. Parkinsons Disease, 2019, Article ID: 3897315.
https://doi.org/10.1155/2019/3897315
[4]  中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍学组. 中国帕金森病消化道症状管理专家共识[J]. 中华神经科杂志, 2022, 55(11): 1225-1235.
[5]  Metta, V., Chung-Faye, G., TS Benamer, H., Mrudula, R., Goyal, V., Falup-Pecurariu, C., et al. (2023) Hiccups, Hypersalivation, Hallucinations in Parkinson’s Disease: New Insights, Mechanisms, Pathophysiology, and Management. Journal of Personalized Medicine, 13, Article 711.
https://doi.org/10.3390/jpm13050711
[6]  李兰兰, 张长国, 冯耀耀, 等. 甲磺酸二氢麦角碱治疗帕金森病流涎的疗效观察[J]. 浙江实用医学, 2023, 28(3): 221-222, 262.
[7]  Polychronis, S., Nasios, G., Dardiotis, E., Messinis, L. and Pagano, G. (2022) Pathophysiology and Symptomatology of Drooling in Parkinson’s Disease. Healthcare, 10, Article 516.
https://doi.org/10.3390/healthcare10030516
[8]  Devic, I., Hwang, H., Edgar, J.S., Izutsu, K., Presland, R., Pan, C., et al. (2011) Salivary Α-Synuclein and DJ-1: Potential Biomarkers for Parkinson’s Disease. Brain, 134, e178.
https://doi.org/10.1093/brain/awr015
[9]  焦悦, 李娟, 吴铁妤, 等. 帕金森病流涎的发生机制及相关因素分析[J]. 安徽医科大学学报, 2021, 56(8): 1300-1304.
[10]  Cersósimo, M.G., Perandones, C., Micheli, F.E., Raina, G.B., Beron, A.M., Nasswetter, G., et al. (2010) Alpha‐Synuclein Immunoreactivity in Minor Salivary Gland Biopsies of Parkinson’s Disease Patients. Movement Disorders, 26, 188-190.
https://doi.org/10.1002/mds.23344
[11]  Lakraj, A., Moghimi, N. and Jabbari, B. (2013) Sialorrhea: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins, 5, 1010-1031.
https://doi.org/10.3390/toxins5051010
[12]  Miller, N., Walshe, M. and Walker, R. (2019) Sialorrhea in Parkinson’s Disease: Prevalence, Impact and Management Strategies. Research and Reviews in Parkinsonism, 9, 17-28.
https://doi.org/10.2147/jprls.s177409
[13]  Špiljak, B. (2022) Sialorrhea and Xerostomia in Parkinson’s Disease Patients. Acta Clinica Croatica, 61, 320-326.
https://doi.org/10.20471/acc.2022.61.02.19
[14]  Pedersen, A., Sørensen, C., Proctor, G. and Carpenter, G. (2018) Salivary Functions in Mastication, Taste and Textural Perception, Swallowing and Initial Digestion. Oral Diseases, 24, 1399-1416.
https://doi.org/10.1111/odi.12867
[15]  石小雪, 郑晋华, 马建军, 等. 帕金森病患者发生吞咽困难的危险因素研究[J]. 中国全科医学, 2022, 25(6): 669-674.
[16]  Srivanitchapoom, P., Pandey, S. and Hallett, M. (2014) Drooling in Parkinson’s Disease: A Review. Parkinsonism & Related Disorders, 20, 1109-1118.
https://doi.org/10.1016/j.parkreldis.2014.08.013
[17]  Arnao, V., Cinturino, A., Valentino, F., Perini, V., Mastrilli, S., Bellavia, G., et al. (2015) In Patient’s with Parkinson Disease, Autonomic Symptoms Are Frequent and Associated with Other Non-Motor Symptoms. Clinical Autonomic Research, 25, 301-307.
https://doi.org/10.1007/s10286-015-0306-x
[18]  赵杨, 刘振国. 帕金森病自主神经功能障碍中西医结合诊治专家共识(2020) [J]. 南京中医药大学学报, 2021, 37(1): 6-12.
[19]  刘林, 郑煊璐, 王呈蕙, 等. 帕金森病流涎的中西医结合诊疗方案探索[J]. 神经病学与神经康复学杂志, 2021, 17(4): 171-176.
[20]  唐怡, 祝小波, 皮持衡. 皮持衡教授运用参苓白术散合缩泉丸治疗流涎症验案浅析[J]. 实用中西医结合临床, 2018, 18(7): 106-107.
[21]  梁俊杰, 魏明清, 倪敬年, 等. 田金洲教授升清降浊法治疗帕金森病非运动症状的临床经验[J]. 世界中医药, 2020, 15(16): 2474-2477.
[22]  吴天晨, 梁艳, 邹丽萍. 温肾养肝方治疗帕金森病流涎及相关非运动症状临床观察[J]. 山西中医, 2023, 39(6): 30-33.
[23]  吉婷, 陆艳, 王苏雷, 等. 赵杨教授从肝肾论治帕金森病流涎举隅[J]. 中西医结合心脑血管病杂志, 2019, 17(20): 3248-3250.
[24]  王明哲, 孙传河, 高鹏琳, 等. 补肾敛涩方改善帕金森病患者流涎与夜尿症状的临床观察[J]. 上海中医药大学学报, 2017, 31(2): 33-35, 39.
[25]  陈叶萍, 孙秀萍. 温针灸法配合功能训练改善老年帕金森病患者吞咽功能障碍分析[J]. 辽宁中医药大学学报, 2019, 21(1): 200-202.
[26]  贾玉洁, 王炯, 张雪竹, 等. 三焦针法结合局部取穴治疗帕金森病流涎30例[J]. 中国针灸, 2023, 43(8): 925-926.
[27]  李琛, 刘园. 温针灸辨证取穴法对帕金森病患者运动症状、非运动症状及脑区血流的影响研究[J]. 新疆中医药, 2022, 40(4): 26-29.
[28]  刘艺雯, 金海鹏. 针灸治疗帕金森病合并吞咽障碍有效性和安全性的meta分析[J]. 中国医药科学, 2023, 13(19): 95-98.
[29]  冯卫星, 杨妙琳, 唐丽娟, 等. 针刺对帕金森病吞咽障碍患者吞咽功能的影响[J]. 中国针灸, 2023, 43(7): 739-742.
[30]  唐丽军, 刘强, 周萍, 等. 咽三针、止颤八针联合运动想象疗法在帕金森吞咽障碍的应用[J]. 中国中医药现代远程教育, 2023, 21(18): 119-121.

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