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单细胞RNA测序在自身免疫性疾病中的研究进展
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Abstract:
单细胞RNA测序(scRNA-seq)是一种新的大规模、高通量技术，其允许在单个细胞的分辨率下分析整个转录组。自身免疫性疾病是确切病因和发病机制仍然未知的一组疾病，深入研究自身免疫性疾病发病机制的细胞和分子机制，确定新的治疗靶点，可以通过使用单细胞转录组测序技术来实现。本文基于最近发表的体外、体内和临床研究结果，综述了scRNA-seq在研究不同自身免疫性疾病中的应用。
Single-cell RNA sequencing (scRNA-seq) is a new large-scale, high-throughput technique that allows the entire transcriptome to be analyzed at the resolution of a single cell. Autoimmune diseases are a group of diseases whose exact etiology and pathogenesis are still unknown, and in-depth study of the cellular and molecular mechanisms of autoimmune disease pathogenesis and identification of new therapeutic targets can be achieved through the use of single-cell transcriptome sequencing technology. Based on the results of recently published in vitro, in vivo, and clinical studies, this article reviews the application of scRNA-seq in the study of different autoimmune diseases.
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