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建瓴汤组方单体对高血压影响机制的研究进展
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Abstract:
建瓴汤出自《医学衷中参西录》，具有镇肝息风、滋阴安神的功效，临床上对高血压(肝阳上亢证)疗效显著。随着中药药理学的发展，中药单体及其有效成分在疾病治疗中的作用机制研究不断增加，系统总结建瓴汤对高血压的影响机制有着重要意义。本文以建瓴汤药物配伍为纲领，对与高血压相关的影响机制进行索引和归类，含有调节肾素–血管紧张素–醛固酮系统、改善内皮功能、改善胰岛素抵抗、调节免疫、调节中枢交感神经、抑制炎症、抑制氧化应激等药理作用，涉及若干信号通路。同时，结合中医理论中的君臣佐使概念进行探讨，为今后研究建瓴汤治疗高血压提供理论参考。
Jianling Decoction is derived from Yixue Zhongzhong Canxilu, which has the effect of soothing liver and calming wind, nourishing Yin and calming nerves, and has significant clinical effect on hypertension (liver-yang hyperactivity syndrome). With the development of TCM pharmacology, studies on the mechanism of action of TCM monomers and their effective components in the treatment of diseases are increasing. It is of great significance to systematically summarize the mechanism of Jianling Decoction’s influence on hypertension. In this paper, based on the drug compatibility of Jianling Decoction, the influencing mechanisms related to hypertension were indexed and classified, including the regulation of renin-angiotensin-aldosterone system, improvement of endothelial function, improvement of insulin resistance, regulation of immunity, regulation of central sympathetic nerve, inhibition of inflammation, inhibition of oxidative stress and other pharmacological effects, involving several signaling pathways. At the same time, combined with the concept of the theory of traditional Chinese medicine to discuss, to provide theoretical reference for the future study of Jianling Decoction treatment of hypertension.
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