|
|
交泰丸作用机制及临床应用的最新进展
|
Abstract:
交泰丸最初是一个治疗失眠、怔忡的丸方，随着现代药理和临床应用的不断研究，交泰丸的作用机制和适用范围不断发展。近两年，从肠道菌群、炎症等方面，对交泰丸、失眠、糖尿病等的研究取得了新的进展。本文结合最新进展，通过系统整理近年有关交泰丸的相关文献资料，从化学组成、药理作用、临床应用和医理创新等方面阐述交泰丸的研究进展，为交泰丸的临床应用和实验研究提供参考。
Jiaotai Pill was originally a pill prescription for the treatment of insomnia and palpitation, but with the continuous study of modern pharmacology and clinical application, the action mechanism and scope of application of Jiaotai Pill are constantly developing. In the past two years, significant progress has been made in the research of Jiaotai pills, insomnia, diabetes, and other related areas such as intestinal flora and inflammation. This paper systematically collates recent literature on Jiaotai pill and expounds on its research progress in terms of chemical composition, pharmacological action, clinical application, and medical innovation. The aim is to provide a reference for the clinical application and experimental research of Jiaotai pill based on the latest advancements.
| [1] | 张乾元. 交泰的易学美学观念[J]. 艺术学界, 2016(2): 64-78. |
| [2] | 蒋丽施, 李潇彧, 罗曦, 等. 黄连的研究进展及其质量标志物预测分析[J]. 中华中医药学刊, 2023, 41(8): 97-109. |
| [3] | Wang, A.-Q., Yuan, Q.-J., Guo, N., et al. (2021) Research Progress on Medicinal Resources of Coptis and Its Isoquinoline Alkaloids. China Journal of Chinese Materia Medica, 46, 3504-3513. |
| [4] | 廖正根, 温佳豪, 徐希强, 等. 肉桂挥发油化学成分及其体外抗菌、抗氧化、抗肿瘤生物活性研究[J]. 中药药理与临床, 2024, 40(1): 69-76. |
| [5] | 南晓强, 李娟娥, 姜小帆, 等. 交泰丸治疗2型糖尿病合并失眠的疗效观察[J]. 陕西中医学院学报, 2015, 38(2): 43-46. |
| [6] | 袁琳, 李慧姣, 胡娜, 等. 交泰丸不同配比组方降糖作用及相关机制探讨[J]. 中国实验方剂学杂志, 2017, 23(8): 130-137. |
| [7] | 王群, 孙世光. 交泰丸治疗失眠网络Meta分析[J]. 中国中西医结合杂志, 2020, 40(5): 560-566. |
| [8] | 杨欣怡, 戴国梁, 陈闪闪, 等. 交泰丸水提液中小檗碱及其单体在大鼠体内药动学比较[J]. 中成药, 2022, 44(10): 3275-3278. |
| [9] | 白丹妮, 魏喜红, 沈梦婷, 等. 交泰丸自微乳在失眠模型大鼠体内的药动学研究[J]. 海南医学院学报, 2022, 28(21): 1614-1620+1626. |
| [10] | 彭平, 解素花, 彭平安, 等. 基于UPLC-PDA生物碱指标性成分含量和特征图谱的不同产区黄连(味连)整体质量表征研究[J]. 世界科学技术-中医药现代化, 2019, 21(10): 2201-2212. |
| [11] | 吴佳, 匡艳辉. 雅连和云连中生物碱的含量测定[J]. 中国现代中药, 2019, 21(4): 464-467. |
| [12] | 王安琪, 李西文, 袁庆军, 等. “失传”中药材宣黄连的分子鉴定与生物碱含量分析[J]. 中国中药杂志, 2021, 46(14): 3514-3521. |
| [13] | Gupta, M., Rumman, M., et al. (2023) Berberine Ameliorates Glucocorticoid-Induced Hyperglycemia: An in Vitro and in Vivo Study. Naunyn-Schmiedeberg’s Archives of Pharmacology, 397, 1647-1658. |
| [14] | 苏成福, 龚曼, 王蕾, 等. 黄连素对HepG2细胞胰岛素抵抗模型葡萄糖激酶的影响[J]. 中医药临床杂志, 2016, 28(9): 1260-1262. |
| [15] | Kim, S.Y., Park, C., Kim, M.Y., Ji, S.Y., Hwangbo, H., Lee, H., et al. (2021) ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts. International Journal of Molecular Sciences, 22, Article 4797. https://doi.org/10.3390/ijms22094797 |
| [16] | Li, J., Zhang, S., Wu, L., Pei, M. and Jiang, Y. (2021) Berberine Inhibited Metastasis through miR-145/Mmp16 Axis in Vitro. Journal of Ovarian Research, 14, Article No. 4. https://doi.org/10.1186/s13048-020-00752-2 |
| [17] | Lyu, Y., Lin, L., Xie, Y., Li, D., Xiao, M., Zhang, Y., et al. (2021) Blood-Glucose-Lowering Effect of Coptidis Rhizoma Extracts from Different Origins via Gut Microbiota Modulation in db/db Mice. Frontiers in Pharmacology, 12, Article 684858. https://doi.org/10.3389/fphar.2021.684358 |
| [18] | Yang, Y., Lu, W., Zhang, X. and Wu, C. (2022) Gut Fungi Differentially Response to the Antipyretic (Heat-Clearing) and Diaphoretic (Exterior-Releasing) Traditional Chinese Medicines in Coptis chinensis-Conditioned Gut Microbiota. Frontiers in Pharmacology, 13, Article 1032919. https://doi.org/10.3389/fphar.2022.1032919 |
| [19] | Zhuang, W., Li, T., Wang, C., Shi, X., Li, Y., Zhang, S., et al. (2018) Berberine Exerts Antioxidant Effects via Protection of Spiral Ganglion Cells against Cytomegalovirus-Induced Apoptosis. Free Radical Biology and Medicine, 121, 127-135. https://doi.org/10.1016/j.freeradbiomed.2018.04.575 |
| [20] | 冯慧聪, 高娜娜, 宋小峰. 小檗碱调控TLR4/p38MAPK通路促进脑缺血再灌注大鼠神经功能恢复[J]. 锦州医科大学学报, 2024, 45(3): 19-24. |
| [21] | 王博, 孙亚男, 王继燕, 等. 小檗碱通过激活SIRT1通路减轻脑缺血再灌注大鼠炎症及凋亡[J]. 中国动脉硬化杂志, 2019, 27(10): 847-852. |
| [22] | 刘冲. 小檗碱通过CNPY2途径减轻脑缺血再灌注损伤的机制研究[M]. 天津: 天津市第四中心医院, 2022. |
| [23] | 黄静. 四氢小檗碱对脑缺血再灌注NLRP3炎症信号通路的干预及保护作用研究[M]. 海口: 海南医学院, 2020. |
| [24] | 杨宏丽, 冯利. 肉桂醛和肉桂提取液抗肿瘤作用及其分子调控机制的研究进展[J]. 山东医药, 2023, 63(13): 104-107. |
| [25] | 洪恺祺, 陈丽, 朱镇华, 等. 肉桂醛通过PINK1/Parkin信号通路介导的线粒体自噬促进糖尿病大鼠创面愈合机制[J]. 中国实验方剂学杂志, 2023, 29(16): 134-143. |
| [26] | 沈梦婷, 白丹妮, 王庆伟, 等. 肉桂及其活性成分抗炎作用机制的研究进展[J]. 中草药, 2022, 53(10): 3218-3225. |
| [27] | 刘瑶瑶. 肉桂调节血糖稳态的物质基础及其作用机制研究[D]: [硕士学位论文]. 湛江: 广东海洋大学, 2022. |
| [28] | 顾嘉琪, 覃骊兰, 苏榕, 等. 肉桂对糖尿病大鼠肠促胰素效应的调节作用[J]. 中国实验方剂学杂志, 2023, 29(12): 104-111. |
| [29] | 马天宇, 平洋, 沈梦婷, 等. 基于网络药理学和实验验证探讨肉桂抗抑郁的作用机制[J]. 中国现代应用药学, 2023, 40(13): 1775-1784. |
| [30] | Qi, L., Mao, H., Lu, X., Shi, T. and Wang, J. (2021) Cinnamaldehyde Promotes the Intestinal Barrier Functions and Reshapes Gut Microbiome in Early Weaned Rats. Frontiers in Nutrition, 8, Article 748503. https://doi.org/10.3389/fnut.2021.748503 |
| [31] | Soyeon, H., Hyun, C.K., Hye, P.J., et al. (2021) Cinnamic Acid Suppresses Bone Loss via Induction of Osteoblast Differentiation with Alteration of Gut Microbiota. The Journal of Nutritional Biochemistry, 101, 108900. https://doi.org/10.1016/j.jnutbio.2021.108900 |
| [32] | 张瑜, 唐娜娜, 王秀峰, 等. 交泰丸对睡眠剥夺大鼠下丘脑GABA受体基因表达的影响[J]. 世界睡眠医学杂志, 2021, 8(11): 1867-1870. |
| [33] | 韩洪翠, 张艳玲, 路芳, 等. 基于分子对接结合靶标mRNA表达的交泰丸镇静催眠药效物质及机制研究[J]. 中国中医药信息杂志, 2021, 28(3): 57-62. |
| [34] | 龚梦鹃, 岳贺, 周祥羽, 等. 基于尿液代谢组学的交泰丸治疗失眠的作用研究[J]. 中药新药与临床药理, 2017, 28(5): 654-658. |
| [35] | 全世建, 李倩, 黑赏艳. 交泰丸对睡眠剥夺大鼠血脑屏障P糖蛋白及下丘脑OrexinA的影响[J]. 中药新药与临床药理, 2015, 26(6): 747-751. |
| [36] | 王秀峰, 唐娜娜, 张瑜, 等. 基于阴阳寤寐学说的交泰丸调节失眠大鼠GABA信号通路的药理作用机制研究[J]. 世界睡眠医学杂志, 2021, 8(11): 1861-1866+70. |
| [37] | 黄运芳, 毕欣宁, 郑伟, 等. 交泰丸对心肾不交型失眠大鼠中枢及外周神经递质的调控作用[J]. 中国中药杂志, 2020, 45(9): 2172-2179. |
| [38] | 岳贺, 周祥羽, 李春苑, 等. 交泰丸干预对氯苯丙氨酸致大鼠失眠的代谢组学研究[J]. 中国中药杂志, 2016, 41(18): 3451-3456. |
| [39] | Li, Z., Ma, P., Huang, Y., Zhang, Z., Zheng, W., Chen, J., et al. (2021) Jiaotai Pill Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats. Chinese Journal of Integrative Medicine, 27, 183-191. https://doi.org/10.1007/s11655-021-3284-y |
| [40] | 赵俊云, 杨晓敏, 胡秀华, 等. 失眠动物模型HPA轴和表观遗传修饰的变化及交泰丸的干预作用[J]. 中医药学报, 2018, 46(4): 19-21. |
| [41] | 骆杰伟, 吴永希, 黄昉萌, 等. 不同中医证型原发性失眠患者肠道菌群差异研究[J]. 中国中医药信息杂志, 2018, 25(4): 28-34. |
| [42] | 全世建, 何树茂, 钱莉莉. 交泰丸交通心肾治疗失眠作用机理研究[J]. 辽宁中医药大学学报, 2011, 13(8): 12-14. |
| [43] | Zou, X., Huang, W., Lu, F., Fang, K., Wang, D., Zhao, S., et al. (2017) The Effects of Jiao-Tai-Wan on Sleep, Inflammation and Insulin Resistance in Obesity-Resistant Rats with Chronic Partial Sleep Deprivation. BMC Complementary and Alternative Medicine, 17, Article No. 165. https://doi.org/10.1186/s12906-017-1648-9 |
| [44] | 黄文雅. 从生物钟蛋白CRY相关炎症信号通路探讨交泰丸改善睡眠和胰岛素抵抗的共同分子机制[D]: [博士学位论文]. 武汉: 华中科技大学, 2018. |
| [45] | 肖迪, 刘俊, 郑桃云. 交泰丸对睡眠剥夺小鼠视交叉上核生物钟基因Clock及Bmal 1表达的影响[J]. 湖北中医药大学学报, 2019, 21(4): 25-29. |
| [46] | 洪曹栋, 尹嘉, 张萌, 等. 基于网络药理学探讨交泰丸治疗失眠的作用机制[J]. 中西医结合心脑血管病杂志, 2020, 18(10): 1522-1530. |
| [47] | 钱拉拉, 张红, 翁金月, 等. 交泰丸结合针刺治疗心肾不交型失眠的疗效及对血清TNF-α、IL-6、IL-1β的影响[J]. 中华中医药学刊, 2019, 37(3): 525-527. |
| [48] | Liu, B., Lin, W., Chen, S., Xiang, T., Yang, Y., Yin, Y., et al. (2019) Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder. Frontiers in Microbiology, 10, Article 1770. https://doi.org/10.3389/fmicb.2019.01770 |
| [49] | 彭维, 申治富, 王亚楠, 等. 肠道菌群对睡眠调节的研究进展[J]. 重庆医学, 2019, 48(19): 3346-3350. |
| [50] | Song, D., Yang, C.S., Zhang, X. and Wang, Y. (2020) The Relationship between Host Circadian Rhythms and Intestinal Microbiota: A New Cue to Improve Health by Tea Polyphenols. Critical Reviews in Food Science and Nutrition, 61, 139-148. https://doi.org/10.1080/10408398.2020.1719473 |
| [51] | Leandro, D.R.L, Vinicius, T.L., Carolina, L.D.B., et al. (2021) Effects of Supplementation with Lactobacillus Probiotics on Insomnia Treatment. Alternative Therapies in Health and Medicine, 27, 178-184. |
| [52] | Yang, Y., Liu, J., Ou, H., Ma, X., Li, J., Shao, B., et al. (2023) Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics. Evidence-Based Complementary and Alternative Medicine, 2023, 1-17. https://doi.org/10.1155/2023/2442505 |
| [53] | Wu, W., Kong, Q., Tian, P., Zhai, Q., Wang, G., Liu, X., et al. (2020) Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders. Engineering, 6, 415-423. https://doi.org/10.1016/j.eng.2019.07.026 |
| [54] | Pushpanathan, P., Mathew, G.S., Selvarajan, S., Seshadri, K.G. and Srikanth, P. (2019) Gut Microbiota and Its Mysteries. Indian Journal of Medical Microbiology, 37, 268-277. https://doi.org/10.4103/ijmm.ijmm_19_373 |
| [55] | 戴国梁, 孙冰婷, 陈泽瑀, 等. 基于定量蛋白质组学技术探讨交泰丸抗抑郁的作用机制[J]. 中国中药杂志, 2023, 48(23): 6500-6508. |
| [56] | Dai, G.-L., Yang, X.-Y., et al. (2021) Effects of Jiaotai Pills on CUMS-Induced Depression Model in Mice Based on Changes of SIRT1 Expression in Hippocampus. China journal of Chinese Materia Medica, 46, 6511-6519. |
| [57] | 雒明池, 梁如, 高杉, 等. 基于NO-cGMP信号转导通路交泰丸对慢性温和不可预知性应激抑郁大鼠的抗抑郁作用研究[J]. 中草药, 2018, 49(18): 4344-4348. |
| [58] | 雒明池, 梁如, 高树明, 等. 基于cAMP-CREB-BDNF信号通路探讨交泰丸抗抑郁的作用机制[J]. 天津中医药, 2018, 35(5): 365-369. |
| [59] | 王月儿. 从肠道菌群角度探讨交泰丸治疗抑郁症的作用机制研究[D]: [硕士学位论文]. 天津: 天津中医药大学, 2022. |
| [60] | Haghighat, N., Rajabi, S. and Mohammadshahi, M. (2019) Effect of Synbiotic and Probiotic Supplementation on Serum Brain-Derived Neurotrophic Factor Level, Depression and Anxiety Symptoms in Hemodialysis Patients: A Randomized, Double-Blinded, Clinical Trial. Nutritional Neuroscience, 24, 490-499. https://doi.org/10.1080/1028415x.2019.1646975 |
| [61] | Sun, J., Wang, F., Hu, X., Yang, C., Xu, H., Yao, Y., et al. (2018) Clostridium Butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis. Journal of Agricultural and Food Chemistry, 66, 8415-8421. https://doi.org/10.1021/acs.jafc.8b02462 |
| [62] | Su, H., Zhang, C., Zou, X., Lu, F., Zeng, Y., Guan, H., et al. (2020) Jiao-Tai-Wan Inhibits Inflammation of the Gut-Brain-Axis and Attenuates Cognitive Impairment in Insomnic Rats. Journal of Ethnopharmacology, 250, Article 112478. https://doi.org/10.1016/j.jep.2019.112478 |
| [63] | Huang, W., Zou, X., Lu, F., Zhang, C., Ren, Y., Xu, L., et al. (2017) Effect of Jiaotai Pill on Intestinal Damage in Partially Sleep Deprived Rats. Chinese Journal of Integrative Medicine, 23, 901-907. https://doi.org/10.1007/s11655-017-2969-8 |
| [64] | Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K.B., et al. (2020) Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 21, Article 6275. https://doi.org/10.3390/ijms21176275 |
| [65] | Chen, G., Yang, X., Yang, X., Li, L., Luo, J., Dong, H., et al. (2017) Jia-Wei-Jiao-Tai-Wan Ameliorates Type 2 Diabetes by Improving βCell Function and Reducing Insulin Resistance in Diabetic Rats. BMC Complementary and Alternative Medicine, 17, Article No. 507. https://doi.org/10.1186/s12906-017-2016-5 |
| [66] | Huang, W., Zou, X., Lu, F., Su, H., Zhang, C., Ren, Y., et al. (2018) Jiao-Tai-Wan Up-Regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-Deprived Rats. Current Medical Science, 38, 704-713. https://doi.org/10.1007/s11596-018-1934-x |
| [67] | 许啸虎, 周俪姗, 邹欣, 等. 交泰丸对2型糖尿病大鼠糖脂代谢及肾脏保护作用的实验研究[J]. 中国医院药学杂志, 2018, 38(2): 111-115. |
| [68] | 唐悦恒, 赵莉, 邹欣, 等. 交泰丸组分配伍改善小鼠胰岛素瘤B细胞脂质沉积的机制研究[J]. 世界中医药, 2021, 16(19): 2813-2819. |
| [69] | 杜月茹, 胡娜, 袁琳, 等. 交泰丸对db/db小鼠脂肪肝防治作用的实验研究[J]. 中国中医药科技, 2016, 23(1): 22-24+56. |
| [70] | Liu, J., Wang, X., Li, Q., Piao, C., Fan, Z., Zhang, Y., et al. (2023) Fecal Metabolomics Combined with 16S rRNA Gene Sequencing to Analyze the Effect of Jiaotai Pill Intervention in Type 2 Diabetes Mellitus Rats. Frontiers in Nutrition, 10, Article 1135343. https://doi.org/10.3389/fnut.2023.1135343 |
| [71] | 王啸南, 袁琳, 胡娜, 等. 交泰丸对高脂饮食诱导肥胖小鼠血脑屏障损伤的影响及机制研究[J]. 中成药, 2024, 46(6): 2058-2062. |
| [72] | 樊博雅, 李晓凤, 邓芳隽, 等. 基于cAMP与钙信号通路探讨交泰丸干预快速型心律失常作用机制[J]. 辽宁中医药大学学报, 2023, 25(10): 10-15. |
| [73] | 陈金红, 刘志超, 樊博雅, 等. 基于整合药理学策略及药效验证探讨交泰丸抗心律失常分子机制[J]. 世界科学技术-中医药现代化, 2022, 24(5): 1993-2002. |
| [74] | 区浩松, 杨阳, 赵俊云. 大鼠交泰丸含药血清预处理对人脑胶质细胞氧化损伤的改善作用及其分子机制[J]. 山东医药, 2022, 62(17): 43-46. |
| [75] | 曾雪爱, 周春权, 郭昕子, 等. 交泰丸对心肾不交失眠模型大鼠睡眠时相和睡眠质量的影响[J]. 中医杂志, 2022, 63(11): 1080-1087. |
| [76] | 曾聪聪, 谢泳泳, 戴春秀, 等. 交泰丸治疗围绝经期心肾不交型失眠随机双盲对照临床研究[J]. 新中医, 2022, 54(8): 41-44. |
| [77] | 朱佳怡. 桂枝甘草龙骨牡蛎汤合交泰丸加减治疗围绝经期失眠心肾不交证的临床研究[D]: [硕士学位论文]. 南京: 南京中医药大学, 2022. |
| [78] | Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., et al. (2022) Time for United Action on Depression: A Lancet-World Psychiatric Association Commission. The Lancet, 399, 957-1022. https://doi.org/10.1016/s0140-6736(21)02141-3 |
| [79] | 靖林林, 孙睿博, 吕志平, 等. 抑郁症病机演变及其内涵探析[J]. 辽宁中医药大学学报, 2022, 24(6): 106-109. |
| [80] | 肖康, 欧政杭, 苏晓鹏, 等. 抑郁障碍肝气郁结证及肾阳亏虚证患者静息态脑功能与外周血肿瘤坏死因子-α相关性研究[J]. 北京中医药大学学报, 2022, 45(9): 903-912. |
| [81] | 于春泉, 李珠, 徐一兰, 等. 交泰丸合用盐酸氟西汀治疗抑郁症心肾不交证的临床疗效观察[J]. 天津中医药, 2020, 37(3): 291-295. |
| [82] | 张君如. 交泰丸加味联合盐酸舍曲林治疗老年人中后抑郁的临床疗效观察[D]: [硕士学位论文]. 济南: 山东中医药大学, 2022. |
| [83] | 聂可馨, 黄召谊, 徐丽君, 等. 基于磁共振氢谱探讨交泰丸改善2型糖尿病非酒精性脂肪肝的临床疗效[J]. 世界中医药, 2021, 16(19): 2820-2825. |
| [84] | 赵一璟, 张婧婧, 范尧夫, 等. 交泰丸治疗2型糖尿病伴失眠症58例临床研究[J]. 江苏中医药, 2021, 53(10): 30-33. |
| [85] | 曹雯, 范尧夫, 刘超, 等. 交泰丸联合降糖康复操对2型糖尿病湿热困脾证患者脂联素及胰岛β细胞功能的影响[J]. 中国医药导报, 2019, 16(33): 63-66. |
