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25-羟基维生素D与2型糖尿病周围神经病变的相关性
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Abstract:
目的：分析25-羟基维生素D与DPN之间的关系。方法：选取2023年2月至2023年12月期间，在北华大学附属医院内分泌科住院的2型糖尿病患者99例，其中68例合并了周围神经病变(DPN)，31例未合并周围神经病变(NDPN)。对两组之间的一般资料进行差异性分析；logistic回归分析25-羟基维生素D与DPN之间的关系，并绘制受试者工作特征曲线(ROC)。结果：DPN组患者的年龄、糖尿病病程高于NDPN组患者(P < 0.05)，DPN组患者的白蛋白、25-羟基维生素D水平低于NDPN组患者(P < 0.05)。单因素Logistic回归分析，结果可见，年龄(OR = 1.129)、糖尿病病程(OR = 1.221)与DPN呈正相关(P < 0.05)，白蛋白(OR = 0.853)、25-羟基维生素D (OR = 0.869)与DPN呈负相关(P < 0.05)。Logistic回归多因素分析显示，25-羟基维生素D每降低1 ng/ml，DPN的发病率增加19.1%。ROC曲线面积为0.721。结论：2型糖尿病患者的25-羟基维生素D水平与DPN显著相关。评估25-羟基维生素D可能是2型糖尿病患者随访中有价值的一部分。
Objective: To analyze the relationship between 25-hydroxyvitamin D and DPN. Method: From February 2023 to December 2023, 99 patients with type 2 diabetes mellitus were hospitalized in the Department of Endocrinology, Affiliated Hospital of Beihua University, of which 68 had peripheral neuropathy (DPN) and 31 had no peripheral neuropathy (NDPN). Differences were analysed for general data between the two groups; logistic regression analysis was used to analyze the relationship between 25-hydroxyvitamin D and DPN, and the receiver operating characteristic curve (ROC) was plotted. Results: The age and duration of diabetes mellitus in the DPN group were higher than those in the NDPN group (P < 0.05), and the levels of albumin and 25-hydroxyvitamin D in the DPN group were lower than those in the NDPN group (P < 0.05). Univariate Logistic regression analysis showed that age (OR = 1.129) and duration of diabetes mellitus (OR = 1.221) were positively correlated with DPN (P < 0.05), while albumin (OR = 0.853) and 25-hydroxyvitamin D (OR = 0.869) were negatively correlated with DPN (P < 0.05). Logistic regression multivariate analysis showed that the incidence of DPN increased by 19.1% for every 1 ng/ml decrease in 25-hydroxyvitamin D. The ROC curve area is 0.721. Conclusion: The level of 25-hydroxyvitamin D in patients with type 2 diabetes mellitus is significantly correlated with DPN. Evaluation of 25-hydroxyvitamin D may be a valuable part of the follow-up of patients with type 2 diabetes.
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