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肺癌与肿瘤炎症微环境相关性的研究进展
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Abstract:
肺癌是临床常见恶性肿瘤之一，其发病率及死亡率居各类恶性肿瘤之首。肿瘤微环境(Tumor Mircroenvirment, TME)与肺癌的发生发展密切相关，而炎症微环境在其中起着重要作用。肿瘤炎症微环境中的炎症细胞和炎症因子通过促进免疫逃逸、肿瘤血管生成、上皮–间充质转化、凋亡等机制，促进肺癌的发生、发展和转移。临床和流行病学研究也显示，慢性感染、炎症、炎症微环境和肺癌之间有着密切的关系。通过对肿瘤炎症微环境的了解，可以更好地解释炎症与肺癌之间的关系，这有利于找到更多的肺癌治疗靶点。
Lung cancer is one of the common clinical malignant tumors, and its incidence rate and mortality rate rank the first among all kinds of malignant tumors. Tumor microenvironment (TME) is closely related to the occurrence and development of lung cancer, and the inflammatory microenvironment plays an important role in it. Inflammatory cells and inflammatory factors in the tumor inflammatory microenvironment promote the occurrence, development and metastasis of lung cancer by promoting immune escape, tumor angiogenesis, epithelial-mesenchymal transition, and apoptosis. Clinical and epidemiological studies have also shown a close relationship between chronic infection, inflammation, the inflammatory microenvironment, and lung cancer. The relationship between inflammation can be better explained with lung cancer, which facilitates finding more therapeutic targets for lung cancer.
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