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青海地区miRNA在缺血性脑卒中中作用的研究进展
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Abstract:
缺血性脑卒中(ischemic stroke, IS)又俗称“中风”是一种很严重且危害中老年人身体健康的心脑血管病，它是全球发病率最高的一种疾病，同时具有很高的致残率和死亡率。miRNA (microRNA又称：微小核糖核酸)是一种内源性基因编码的长度为19~25 nt非编码的单链RNA分子且在动植物中进行转录后从而参与基因表达调控。近年来大量研究表明miRNA不但参与调控大部分生物学的过程，而且和许多疾病的发展存在着密切的关系。本文主要探讨青海地区miRNA与IS关系的研究进展。
Ischemic stroke (IS), also known as “stroke”, is a serious cardiovascular and cerebrovascular disease that jeopardizes the health of middle-aged and elderly people with the highest incidence in the world, it has a high rate of disability and mortality. miRNA (microRNA also known as microRNAs) are 19~25 nt non-coding single-stranded RNA molecules encoded by endogenous genes that are transcribed in plants and animals to participate in regulation of gene expression. Recent studies have shown that the miRNA are not only involved in most biological processes, but also closely related to the development of many diseases. This paper mainly discusses the research progress of the relationship between miRNA and IS in Qinghai region.
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