药物联合MECT与rTMS治疗对抑郁症患者认知功能的影响研究
Research on the Effects of MECT and rTMS Treatment on Cognitive Function in Patients with Depression

目的：研究药物合并不同物理治疗方法对抑郁症患者认知功能的影响。方法：选取山东省戴庄医院2022年08月~2023年08月收治的180例被确诊为抑郁症的患者作为研究对象，随机分为3组，每组60例患者，对照组采用药物治疗，观察1组在对照组的基础上加以重复经颅磁刺激(rTMS)治疗，观察2组在对照组基础上加以无抽搐电休克(MECT)治疗。比较两组患者的临床效果、治疗前后抑郁状态以及认知功能的改善。结果：观察1组总有效率96.67%，观察2组总有效率86.67%，高于对照组71.67%，差异有统计学意义(P < 0.05)。治疗后，观察1组HAMD评分、观察2组评分低于对照组，观察1组PDQ-D、MMSE、CFI评分高于观察2组和对照组，差异有统计学意义(P < 0.05)。结论：抑郁症患者接受药物治疗并联合进行经颅磁刺激治疗疗效优于无抽搐电休克治疗，经颅磁刺激治疗能进一步改善患者抑郁状态，促进认知功能恢复，为临床提供标准化治疗方案。
Objective: To investigate the effects of different physical therapy methods on cognitive function in patients with depression. Method: 180 patients diagnosed with depression who were admitted to Daizhuang Hospital in Shandong Province from August 2022 to August 2023 were selected as the study subjects. They were randomly divided into three groups, with 60 patients in each group. The control group received drug treatment, while the observation group received repeated transcranial magnetic stimulation (rTMS) treatment on the basis of the control group. The observation group received non convulsive electroconvulsive therapy (MECT) on the basis of the control group. The clinical outcomes, depression status before and after treatment, and improvement in cognitive function between two groups of patients were compared. Result: The total effective rate of Group 1 was observed to be 96.67%, while the total effective rate of Group 2 was observed to be 86.67%, which was higher than the control group’s 71.67%, and the difference was statistically significant (P < 0.05). After treatment, the HAMD score of Group 1 was observed, and the scores of Group 2 were lower than the control group. The PDQ-D, MMSE, and CFI scores of Group 1 were higher than those of Group 2 and the control group, and the difference was statistically significant (P < 0.05). Conclusion: Patients with depression who receive medication treatment combined with transcranial magnetic stimulation therapy have better therapeutic effects than those who do not have convulsive electroconvulsive therapy. Transcranial magnetic stimulation therapy can further improve the patient’s depressive state, promote cognitive function recovery, and provide standardized treatment plans for clinical practice.