The Dongsithouane National Production Forest (DNPF) is one of the largest natural forest areas in Savannakhet, Lao PDR, which has been a vital support for the local community’s livelihood, Recently, significant changes in land use and land cover (LULC) have been observed in this area, leading to a reduction of natural forests. There were two separate methods of this study: firstly, to identify LULC changes across three different periods, spectral imagery from the Landsat 5 Thematic Mapper (TM) for the years 2001 and 2011, and the Landsat 8 Operational Land Imager (OLI) for 2021 were used as the primary data sources. The satellite images were preprocessed for various forest classes, including pretreatment of the top of atmosphere reflectance by using QGIS software’s semi-automatic classification plug-in (SCP), and ArcGIS was used for post-classification. A supervised classification approach was applied to the satellite images from 2001, 2011, and 2021 to generate diverse maps of LULC. Secondly, a household survey dataset was used to investigate influential factors. Approximately 220 households were interviewed in order to collect socio-economic information (including data on population growth, increased business activities, location of the area, agriculture land expansion, and need for settlement land). Household survey data was analyzed by using SPSS. Descriptive statistics, including frequency distributions and percentages, were applied to observe characteristics. Additionally, a binary logistic regression model was used to analyze the socioeconomic factors related to LULC change in DNPF. Key findings indicated a decline in natural forest areas within the study site. Specifically, both dry dipterocarp forest (?11.35%) and mixed deciduous forest (?0.18%) decreased from 2001 to 2021. The overall accuracy of the LULC maps was 94%, 86%, and 89% for the years 2001, 2011, and 2021 respectively. In contrast, agricultural land increased significantly by 155.70%, while built-up land, and water bodies increased by 65.54% and 35.33%, respectively. The results also highlighted a significant increase in construction land, up to 65.54%. Furthermore, the study found a correlation between agricultural expansion and a reduction of forest areas, along with an increase in built-up land along the forest areas’ boundaries. Timber exploitation and charcoal production also contributed to the decline in forest cover. The logistic regression model identified significant determinants of LULC change, including the area’s location, agricultural
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