帕罗西汀治疗帕金森合并焦虑临床效果探究
An Investigation of the Clinical Effects of Paroxetine in the Treatment of Parkinson’s Comorbid Anxiety

帕金森病是一种影响中老年人的运动障碍疾病。它主要有四种运动症状(震颤、肌肉紧张、运动迟缓和姿势障碍)。此外，大多数患者在发病初期会出现非运动症状，有些患者在出现运动症状之前就会出现非运动症状。帕金森病对老年患者的生活质量有着很大的影响，特别是在精神症状这方面。其中一些症状，如焦虑，会随着病情的发展而出现和加重，不仅会给患者本人，也会给其家人带来极大的痛苦。现代医学越来越关注帕金森病，临床试验的目的是找出改善患者预后和生活质量的方法。以往的研究侧重于治疗运动障碍，而忽略了焦虑症状等非运动症状。帕金森病是一种无法独立治愈的疾病。治疗不仅会延缓病情的发展，还会使病情逐渐恶化，严重时还会导致不可逆转的后果，如感觉障碍、广泛性疼痛和神经变性，如四肢瘫痪。因此，一旦发现帕金森病，必须及早诊断并立即开始治疗。在本研究中，我们观察并研究了帕罗西汀治疗焦虑相关帕金森病的临床效果。
Parkinson disease is a disease of motor disorders that affects middle-aged and elderly people. It has four main motor symptoms (tremor, muscle tension, bradykinesia, and postural disorders). Furthermore, most patients develop non-motor symptoms at the beginning of the disease, and some patients develop non-motor symptoms before they appear. PD has a great impact on the quality of life of elderly patients, especially in this aspect of psychiatric symptoms. Some of these symptoms, such as anxiety, can appear and worsen as the disease progresses, causing great pain not only to the patient himself, but also to his family. Modern medicine is increasingly focused on Parkinson’s disease, and clinical trials aim to find ways to improve patient outcomes and quality of life. Previous studies focused on treatment of motor disorders and ignoring non-motor symptoms such as anxiety symptoms. PD is a disease that cannot be cured independently. Treatment will not only delay the development of the disease, but will also gradually worsen the condition, and in severe cases can also lead to irreversible consequences, such as sensory impairment, generalized pain, and neurodegeneration, such as quadriplegia. Therefore, once PD is detected, it must be diagnosed early and treatment started immediately. In this study, we observed and investigated the clinical effects of paroxetine in the treatment of anxiety-related parkinsonian disease.