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减肥“药”的作用机理与减肥研究新进展
The Function Mechanism of Weight Loss Drugs and New Research Progress in Weight Loss

DOI: 10.12677/hjfns.2024.133040, PP. 310-317

Keywords: 肥胖,减肥“药”,巨噬细胞减肥,基因疗法减肥
Obesity
, Weight Loss Drugs, Macrophage Weight Loss, Gene Therapy Weight Loss

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Abstract:

本文首先分析了减肥“药”的四种作用机理,然后针对减肥研究的两个前沿研究方向巨噬细胞减肥和基因疗法减肥的最新研究成果进行综述。
The four function mechanisms of weight loss drugs has been analyzed first in this article. Then, a literature review of latest research result on macrophage weight loss and gene therapy weight loss has been done.

References

[1]  Chen, K., Shen, Z.W., Gu, W.J., et al. (2023) Prevalence of Obesity and Associated Complications in China: A Cross-Section, Real-World Study in 15.8 Million Adults. Diabetes Obesity and Metabolism, 25, 3390-3399.
[2]  “一胖毁所有”! 肥胖或促进血管新生, 加速肿瘤生长, 别不当回事[Z/OL].
https://m.39.net/news/a_12704252.html, 2024-07-09.
[3]  The GBD 2015 Obesity Collaborators (2017) Health Effect of Overweight and Obesity in 195 Countries over 25 Years. The New England Journal of Medicine, 377, 13-27.
[4]  Bapat, S.P., Whitty, C., Marson, A., et al. (2022) Obesity Alters Pathology and Treatment Response in Inflammatory Disease. Nature, 604, 337-342.
[5]  Elmaleh-Sachs, A., Schwartz, J.L., Bramante, C.T., Nicklas, J.M., Gudzune, K.A. and Jay, M. (2023) Obesity Management in Adults: A Review. JAMA, 330, 2000-2015.
https://doi.org/10.1001/jama.2023.19897
[6]  Zeng, W., Pirzgalska, R.M., Pereira, M.M.A., Kubasova, N., Barateiro, A., Seixas, E., et al. (2015) Sympathetic Neuro-Adipose Connections Mediate Leptin-Driven Lipolysis. Cell, 163, 84-94.
https://doi.org/10.1016/j.cell.2015.08.055
[7]  谭莺, 雷普润, 唐齐, 等. 中国肥胖症药物治疗的现状及效果分析[J]. 中国预防医学杂志, 2024, 25(4): 413-418.
[8]  梁淑, 黄蓉, 王略力, 等. 减肥产品及其药理作用机制研究进展[J]. 食品与营养科学, 2022, 11(1): 73-79.
[9]  Acín-Pérez, R., Iborra, S., Martí-Mateos, Y., Cook, E.C.L., Conde-Garrosa, R., Petcherski, A., et al. (2020) Fgr Kinase Is Required for Proinflammatory Macrophage Activation during Diet-Induced Obesity. Nature Metabolism, 2, 974-988.
https://doi.org/10.1038/s42255-020-00273-8
[10]  Cox, N., Crozet, L., Holtman, I.R., et al. (2021) Diet-Regulated Production of PDGFcc by Macrophages Controls Energy Storage. Science, 373, eabe9383.
[11]  王延淼, 信立霞, 张玉荣, 等. 血小板衍生生长因子及受体在肥胖和糖尿病中的研究进展[J]. 临床医学进展, 2023, 13(3): 3117-3124.
[12]  Wu, S., Qiu, C., Ni, J., Guo, W., Song, J., Yang, X., et al. (2024) M2 Macrophages Independently Promote Beige Adipogenesis via Blocking Adipocyte Ets1. Nature Communications, 15, Article No. 1646.
https://doi.org/10.1038/s41467-024-45899-4
[13]  Tsagkaraki, E., Nicoloro, S.M., DeSouza, T., Solivan-Rivera, J., Desai, A., Lifshitz, L.M., et al. (2021) CRISPR-Enhanced Human Adipocyte Browning as Cell Therapy for Metabolic Disease. Nature Communications, 12, Article No. 6931.
https://doi.org/10.1038/s41467-021-27190-y
[14]  Wakefield, C.B., Lee, V.R., Johnston, D., Boroumand, P., Pillon, N.J., Sayedyahossein, S., et al. (2021) Pannexin 3 Deletion Reduces Fat Accumulation and Inflammation in a Sex-Specific Manner. International Journal of Obesity, 46, 726-738.
https://doi.org/10.1038/s41366-021-01037-4
[15]  Xia, W.M., Veeragandham, P., Cao, Y., et al. (2024) Obesity Causes Mitochondrial Fragmentation and Dysfunction in White Adipocytes Due to RalA Activation. Nature Metabolism, 6, 273-289.
[16]  Zhao, Y., Chukanova, M., Kentistou, K.A., Fairhurst-Hunter, Z., Siegert, A.M., Jia, R.Y., et al. (2024) Protein-Truncating Variants in BSN Are Associated with Severe Adult-Onset Obesity, Type 2 Diabetes and Fatty Liver Disease. Nature Genetics, 56, 579-584.
https://doi.org/10.1038/s41588-024-01694-x
[17]  Funcke, J., Moepps, B., Roos, J., von Schnurbein, J., Verstraete, K., Fröhlich-Reiterer, E., et al. (2023) Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity. New England Journal of Medicine, 388, 2253-2261.
https://doi.org/10.1056/nejmoa2204041
[18]  Wang, D., Townsend, L.K., DesOrmeaux, G.J., Frangos, S.M., Batchuluun, B., Dumont, L., et al. (2023) GDF15 Promotes Weight Loss by Enhancing Energy Expenditure in Muscle. Nature, 619, 143-150.
https://doi.org/10.1038/s41586-023-06249-4

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