增色方联合毫火针治疗对白癜风患者抗氧化应激反应及生活质量的影响
The Effect of Color Enhancing Formula Combined with Filiform Needle Therapy on Antioxidant Stress Response and Quality of Life in Vitiligo Patients

目的：探讨增色方联合毫火针治疗对白癜风患者抗氧化应激反应及生活质量的影响。方法：选取本院2023年6月~2024年5月收治的100例白癜风患者，随机分为2组，西医组50例采用0.1%他克莫司软膏治疗，中西医组50例采用0.1%他克莫司软膏 + 增色方联合毫火针治疗。对比2组患者的中医证候积分、皮损面积、抗氧化应激反应[超氧化物歧化酶(SOD)、丙二醛(MDA)]、生活质量[皮肤病生活质量指数(DLQI)]、总体疗效。结果：2组治疗后中医证候积分的各项评分均较本组治疗前降低，中西医组低于西医组，P < 0.05。2组治疗后的皮损面积均较本组治疗前缩小，中西医组小于西医组，P < 0.05。2组治疗后的SOD均较本组治疗前提高，MDA均较本组治疗前降低，中西医组的SOD高于西医组，MDA低于西医组，P < 0.05。2组治疗后的DLQI评分均较本组治疗前降低，中西医组低于西医组，P < 0.05。中西医组的总有效率高于西医组，P < 0.05。结论：增色方联合毫火针治疗白癜风的效果较好，可减轻患者症状，缩小皮损面积，改善抗氧化应激反应指标，提高生活质量，值得运用。
Objective: To explore the effects of Zengse Fang combined with Haohuo Needle therapy on antioxidant stress response and quality of life in vitiligo patients. Method: 100 vitiligo patients admitted to our hospital from June 2023 to May 2024 were randomly divided into two groups. The Western medicine group (50 cases) was treated with 0.1% tacrolimus ointment, while the Chinese and Western medicine group (50 cases) was treated with 0.1% tacrolimus ointment + color enhancing formula combined with filiform needle. Compare the traditional Chinese medicine syndrome score, skin lesion area, antioxidant stress response (superoxide dismutase (SOD), malondialdehyde (MDA)), quality of life (Dermatological Quality of Life Index (DLQI)), and overall efficacy between two groups of patients. Result: After treatment, the scores of traditional Chinese medicine syndrome scores in both groups decreased compared to before treatment, with the Chinese and Western medicine group being lower than the Western medicine group, P < 0.05. The area of skin lesions in both groups decreased compared to before treatment, and the Chinese and Western medicine group was smaller than the Western medicine group, P < 0.05. The SOD in both groups increased compared to before treatment, and MDA decreased compared to before treatment. The SOD in the Chinese and Western medicine group was higher than that in the Western medicine group, and MDA was lower than that in the Western medicine group, P < 0.05. The DLQI scores in both groups decreased compared to before treatment, with the Chinese and Western medicine group being lower than that in the Western medicine group, P < 0.05. The total effective rate in the Chinese and Western medicine group was higher than that in the Western medicine group, P < 0.05. Conclusion: The combination of Zengse Fang and Haohuo Needle has a good effect on treating vitiligo, which can alleviate