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中医药调控自噬治疗子宫内膜异位症的研究进展
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Abstract:
子宫内膜异位症(EMs)是一种持续性、炎症性和雌激素应答性妇科疾病，虽呈良性病变，却具备侵袭、转移及复发等恶性行为，因其确切发病机制尚不明确，是目前临床常见的难治性妇科疾病，近些年来通过调控自噬水平来治疗EMs已经成为一个研究热点，且越来越多的研究发现，中医的中药单体、复方及针灸对于调控自噬水平具有显著疗效，其机制主要是通过干预自噬相关蛋白以及信号通路，降低炎症水平、调节激素受体从而调控子宫内膜异位细胞的自噬水平，缓解EMs患者的临床症状。本文对中医药调控细胞自噬治疗EMs的研究进行归纳总结，以期为EMs的治疗提供思路和方法。
Endometriosis (EMs) is a persistent, inflammatory and estrogen-responsive gynecologic disease. Although it presents benign lesions, it has malignant behaviors such as invasion, metastasis and recurrence. Due to its unclear pathogenesis, EMs is currently a common and refractory gynecologic disease in clinical practice. In addition, more and more studies have found that TCM monomer, compound and acupuncture have significant effects on the regulation of autophagy level. The mechanism is mainly to reduce inflammation level and regulate hormone receptors by interfering with autophagy related proteins and signaling pathways, thereby regulating autophagy level of endometriosis cells and alleviating clinical symptoms of EMs patients. In this paper, the research on the regulation of autophagy by Chinese medicine in the treatment of EMs was summarized in order to provide ideas and methods for the treatment of EMs.
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