|
短肽制剂在终末期患者营养支持中的应用进展
|
Abstract:
终末期患者存在感染、高热和低蛋白血症等情况,导致肠道的耐受性下降,从而应用传统的整蛋白型肠内营养制剂容易引起腹胀、腹泻等不良反应,短肽型肠内营养制剂是经过水解处理预消化型营养制剂,能减少胃肠道副反应,使其耐受性增强。本文通过对肠内营养、短肽制剂的优势及功能特点和短肽制剂在终末期患者营养支持的应用和影响进行论述,探讨其临床应用治疗价值,以期为相关临床护理工作提供有价值的参考。
In patients with end-stage infection, high fever and hypoalbuminemia, etc., resulting in a decline in the tolerance of the intestinal tract, thus the application of traditional whole protein type enteral nutrition preparations is associated with abdominal distention, diarrhea and other adverse reactions. Short peptide enteral nutrition preparations are predigestive supplements through hydrolysis processing beforehand, can reduce gastrointestinal side effects and enhance its tolerance. In this paper, the advantages and functional characteristics of enteral nutrition, short peptide preparation and the application and influence of short peptide preparation in the nutritional support of end-stage patients were discussed, and the clinical application and therapeutic value of short peptide preparation were discussed, in order to provide valuable reference for relevant clinical nursing work.
[1] | 刘玲, 朱丽, 陈英. 临床营养支持研究进展[J]. 齐鲁护理杂志, 2018, 24(23): 96-99. |
[2] | 马红琳, 杨婧, 金秋, 等. 终末期肝病营养支持的研究现状[J]. 临床肝胆病杂志, 2022, 38(1): 215-219. |
[3] | 宋辉, 都军. 急危重症病人营养支持的临床研究[J]. 健康大视野, 2021(21): 80. |
[4] | Berseth, C.L., Mitmesser, S.H., Ziegler, E.E., Marunycz, J.D. and Vanderhoof, J. (2009) Tolerance of a Standard Intact Protein Formula versus a Partially Hydrolyzed Formula in Healthy, Term Infants. Nutrition Journal, 8, Article No. 27. https://doi.org/10.1186/1475-2891-8-27 |
[5] | 程艳艳. 重症患者规范化肠内营养护理流程的构建与应用研究[D]: [硕士学位论文]. 湖州: 湖州师范学院, 2018. |
[6] | 郑文玲. 肠内营养的护理[J]. 医学信息, 2015(z2): 74. |
[7] | Felblinger, D.M. (2003) Malnutrition, Infection, and Sepsis in Acute and Chronic Illness. Critical Care Nursing Clinics of North America, 15, 71-78. https://doi.org/10.1016/s0899-5885(02)00040-0 |
[8] | Amati, L., Cirimele, D., Pugliese, V., Covelli, V., Resta, F. and Jirillo, E. (2003) Nutrition and Immunity: Laboratory and Clinical Aspects. Current Pharmaceutical Design, 9, 1924-1931. https://doi.org/10.2174/1381612033454252 |
[9] | Korina, E., Naifert, S., Morozov, R., et al. (2020) Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method. Journal of Visualized Experiments, 158, e60526. https://doi.org/10.3791/60526 |
[10] | 朱大年, 王庭槐. 生理学[M]. 北京: 人民卫生出版社, 2018: 24-30. |
[11] | 杨孝清, 邱维诚, 朱良纲, 等. 肠内与肠外营养在老年食管癌病人围手术期应用的比较[J]. 肠外与肠内营养, 2013, 20(1): 8-11+14. |
[12] | 陈静, 黄迎春, 王慧. 不同肠内营养制剂配伍反应观察[J]. 护理研究, 2018, 32(8): 1313-1314. |
[13] | 王浩. 短肽型肠内营养制剂对呼吸重症患者疾病康复的影响[J]. 中华养生保健, 2020, 38(12): 185-186. |
[14] | 黄蕾. 整蛋白型与短肽型肠内营养制剂在胃癌术后患者中应用比较[J]. 现代医用影像学, 2018(7): 2570-2572. |
[15] | Muscaritoli, M, Arends, J., Bachmann, P., et al. (2021) ESPEN Practical Guideline: Clinical Nutrition in Cancer. Clinical Nutrition, 40, 2898-2913. |
[16] | 田俊梅, 赵永飞, 郅文娟. 短肽型肠内营养制剂对胃癌根治术后患者胃肠功能及营养状态的改善作用研究[J]. 中国合理用药探索, 2020, 17(10): 35-38. |
[17] | Huang, X.J., Guo, F.F., Li, F., et al. (2020) Nutritional Support in Children with Pneumonia on Mechanical Ventilation by Short-Peptide Enteral Nutrition Formula. Chinese Journal of Contemporary Pediatrics, 22, 1209-1214. |
[18] | Wang, Y., Li, Y., Li, Y., Li, H. and Zhang, D. (2022) Comparisons between Short-Peptide Formula and Intact-Protein Formula for Early Enteral Nutrition Initiation in Patients with Acute Gastrointestinal Injury: A Single-Center Retrospective Cohort Study. Annals of Translational Medicine, 10, 573-573. https://doi.org/10.21037/atm-22-1837 |
[19] | 邓妍. 短肽型肠内营养制剂应用于消化道恶性肿瘤的效果观察[J]. 医药前沿, 2019, 9(28): 71-72. |
[20] | Wischmeyer, P.E. (2020) Overcoming Challenges to Enteral Nutrition Delivery in Critical Care. Current Opinion in Critical Care, 27, 169-176. https://doi.org/10.1097/mcc.0000000000000801 |
[21] | Baiu, I. and Spain, D.A. (2019) Enteral Nutrition. Journal of American Medical Association, 321, Article 2040. https://doi.org/10.1001/jama.2019.4407 |
[22] | 刘一宁, 马景涛, 高志远, 等. 短肽型肠内营养制剂对慢性乙型肝炎合并肾功能衰竭患者的临床运用分析[J]. 世界华人消化杂志, 2021, 29(1): 15-20. |
[23] | 邹小兰, 魏建红. 基于营养风险评估策略下的营养干预对肝硬化患者营养状况及肝功能的影响[J]. 中国实用护理杂志, 2019, 35(33): 2575-2579. |