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Pharmacy Information 2024
γδT细胞在自身免疫性疾病发生发展中的参与和作用
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Abstract:
自身免疫性疾病作为一种系统性慢性疾病，其发病机制涉及多种细胞(如T细胞、B细胞、巨噬细胞等)及其相互作用。γδT细胞是一种独特的T淋巴细胞亚群，连接先天性和适应性免疫应答，参与多种生理和病理过程。近年来的研究表明，γδT细胞与多种自身免疫性疾病的发生发展相关。本文对其研究概况进行综述，为阐明自身免疫性疾病的病机及相关药物研发提供参考。
As a systemic chronic disease, the pathogenesis of autoimmune diseases involves various cells (such as T cells, B cells, macrophages, etc.) and their interaction. γδT cells are a unique subset of T lymphocytes bridging innate and adaptive immune responses, participating in various physiological and pathological processes. In recent years, numerous studies have indicated the association of γδT cells with the onset and progression of several autoimmune diseases. This review summarizes the involvement and roles of γδT cells in the occurrence and development of autoimmune diseases.
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